Familiarity, Knowledge and Practices of Healthcare Professionals Regarding the Pharmacovigilance of Biological Medicines in Lusaka, Zambia: A Multi-Facility Cross-Sectional Study — Oak Academic Publishing
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Familiarity, Knowledge and Practices of Healthcare Professionals Regarding the Pharmacovigilance of Biological Medicines in Lusaka, Zambia: A Multi-Facility Cross-Sectional Study
Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
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Department of Medical Informatics, Erasmus MC, Rotterdam, Netherlands
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Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
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Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
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Department of Medicines Control, Zambia Medicines Regulatory Authority, Lusaka, Zambia
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Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK
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Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
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Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
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Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
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Department of Physiological Sciences, School of Medicine, University of Zambia, Lusaka, Zambia
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Department of Bioanalysis, Ghent University, Ottergemsesteenweg, Ghent, Belgium
1 Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
2 Department of Medical Informatics, Erasmus MC, Rotterdam, Netherlands
3 Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
4 Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
5 Department of Medicines Control, Zambia Medicines Regulatory Authority, Lusaka, Zambia
6 Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK
7 Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
8 Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
9 Department of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia
10 Department of Physiological Sciences, School of Medicine, University of Zambia, Lusaka, Zambia
11 Department of Bioanalysis, Ghent University, Ottergemsesteenweg, Ghent, Belgium
Background : Pharmacovigilance of biological medicines is crucial because it ensures that medicines meet the World Health Organization (WHO) standards. In Zambia, there is little information on healthcare professionals’ familiarity, knowledge and practices on the pharmacovigilance of biological and biosimilar medicines. Therefore, this study investigated the familiarity, knowledge, and practices related to the pharmacovigilance (PV) of biological and biosimilar medicines at selected hospitals in Lusaka, Zambia . Methods : The study was an analytical questionnaire-based cross-sectional study conducted among healthcare professionals (HCPs) at the Adult hospital, Cancer Diseases hospital, Paediatrics hospital and Women and New Born Hospital in Lusaka. Data were collected over four weeks in May and June 2021 and subsequently analysed using IBM SPSS version 21. The statistical significance was set at a 95% confidence interval. Results : Of 245 participants, only 115 (48.9%) of the HCPs were familiar with biological medicines to a basic understanding. Regarding the term biosimilars, most of the HCPs (40.9%) never heard of this word. The mean score for knowledge regarding the PV considerations of biological medicines was 4.1 out of 8 questions. Most HCPs used non-proprietary names (44.2%) when prescribing, dispensing, or administering biological medicines. Additionally, more than half (57.3%) of HCPs did not record batch numbers when dispensing or administering biological medicines. Conclusion : Healthcare professionals were more familiar with the term biological medicines than biosimilars. Healthcare professionals generally scored poorly when their knowledge regarding the PV considerations of biological medicines was assessed. Thus, there is a need to provide adequate training and continuous professional development among healthcare professionals on the pharmacovigilance of biological and biosimilar medicines.
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