Reducing Effect of Parkia biglobosa (Jacq.) R. Br. ex G. Don Fruit Pulp on Food Intake in Healthy NMRI Mice — Oak Academic Publishing
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Reducing Effect of Parkia biglobosa (Jacq.) R. Br. ex G. Don Fruit Pulp on Food Intake in Healthy NMRI Mice
Département Médecine et Pharmacopée Traditionnelles—Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST), Ouagadougou, Burkina Faso
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Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
,
Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
,
Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
,
Département Médecine et Pharmacopée Traditionnelles—Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST), Ouagadougou, Burkina Faso
,
Département Médecine et Pharmacopée Traditionnelles—Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST), Ouagadougou, Burkina Faso
,
Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
,
Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
,
Université Nazi Boni, Bobo-Dioulasso, Burkina Faso
,
Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
,
Université Nazi Boni, Bobo-Dioulasso, Burkina Faso
,
Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
,
Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
,
Laboratoire de Biochimie, Centre Hospitalier Universitaire Sourou Sanou, Bobo-Dioulasso, Burkina Faso
1 Département Médecine et Pharmacopée Traditionnelles—Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST), Ouagadougou, Burkina Faso
2 Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
3 Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
4 Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
5 Département Médecine et Pharmacopée Traditionnelles—Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST), Ouagadougou, Burkina Faso
6 Département Médecine et Pharmacopée Traditionnelles—Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST), Ouagadougou, Burkina Faso
7 Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
8 Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
9 Université Nazi Boni, Bobo-Dioulasso, Burkina Faso
10 Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
11 Université Nazi Boni, Bobo-Dioulasso, Burkina Faso
12 Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
13 Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Bobo-Dioulasso, Burkina Faso
14 Laboratoire de Biochimie, Centre Hospitalier Universitaire Sourou Sanou, Bobo-Dioulasso, Burkina Faso
Obesity is a chronic condition characterised by excess body fat that leads to increased body weight. One of the most effective ways to treat obesity is to use appetite suppressants to reduce food intake. This study aimed to evaluate in vivo reduction of food intake and weight gain caused by Parkia big l obosa (Pb) fruit pulp. Twenty-four healthy NMRI mice divided into four groups were used for the experiment. Group 1, considered the negative control, received distilled water. Groups 2, 3, and 4 were administered daily with 100, 250 and 500 mg/kg body weight of Pb fruit pulp powder suspension, respectively. The reduction in food intake was assessed in two phases: acute food intake for one day (24 h) and long-term food intake for seven weeks. Nutrient parameters and phenolic compounds in Pb fruit pulp were quantified. The results showed that Pb fruit pulp had a significant effect on reducing acute food intake. At a dose of 250 mg/kg, Pb had the best activity in reducing acute food intake, with an overall reduction rate of approximately 47.98% ± 1.17% compared to the control. Repeated daily administration inhibited food intake with all three doses for 13 days compared to control. Food intake was significantly decreased for up to 31 days by taking a 100 mg/kg dose of Pb (p = 0.0174). Weight gain was significantly lower (p = 0.0003) in mice treated with 100 mg/kg Pb than in controls at the end of 7 weeks. According to the nutritional composition study, Pb fruit pulp contains an abundance of total carbohydrates (68.81% ± 0.32%) and crude fiber (14.35% ± 0.21%). This study demonstrated that Pb fruit pulp effectively reduces food intake in healthy mice. Pb pulp’s richness in crude fiber and phenolic compounds makes it a potential aid in managing obesity.
KeywordsAppetite-SuppressantFood IntakePar kia biglobosa Fruit Pulp
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