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Synthesis and Evaluation of the Anti-Inflammatory Activity of the Schiff Base Ligand (2-(1H-Benzo[d]imidazol-2-Yl)phenol) and Its Co(II) and Mn(III) Complexes

¹ Department of Chemistry, Faculty of Science and Technology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
² Laboratory of Pharmacology and Pharmacodynamics, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Sénégal
³ Department of Chemistry, Faculty of Science and Technology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
⁴ Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
⁵ Laboratory of Pharmacology and Pharmacodynamics, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Sénégal
⁶ Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
⁷ Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
⁸ Laboratory of Pharmacology and Pharmacodynamics, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Sénégal
⁹ Laboratory of Pharmacology and Pharmacodynamics, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Sénégal
¹⁰ Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
¹¹ Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
¹² Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
¹³ Department of Chemistry, Faculty of Science and Technology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
¹⁴ Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Cheikh Anta Diop University of Dakar, Dakar, Senegal

Pharmacology & Pharmacy·Volume 17 (2026)·Pages 142–154·Published 12 February 2026·DOI10.4236/pp.2026.172007

Abstract

Coordination complexes are inorganic compounds that play an important role in medicinal chemistry. They possess numerous properties such as denticity, flexibility, reactivity, and stability. Schiff base ligands are organic compounds obtained from the condensation reaction between a carbonyl compound and a primary amine. They are used in many fields, including analytical, biological, organic, and inorganic industries. In this context, we synthesized a Schiff base ligand as well as two dinuclear complexes of cobalt and manganese. Various techniques such as IR, 1H and 13C NMR, UV-visible, conductimetry, magnetism, and XRD were used to characterize these compounds. The local anti-inflammatory activity of these compounds and the reference indomethacin was evaluated in mice by measuring the inflammatory response to the topical application of an irritant (croton oil) to the ear. The results of the comparative study of the anti-inflammatory properties of the free ligand and its complexes led to the conclusion that the complexes are more active than the ligand.

KeywordsSchiff BasesComplexesCobaltManganeseAnti-Inflammatory Activity

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Synthesis and Evaluation of the Anti-Inflammatory Activity of the Schiff Base Ligand (2-(1H-Benzo[d]imidazol-2-Yl)phenol) and Its Co(II) and Mn(III) Complexes

Abstract

References (31)