Effect of Antihypertensive Drug Therapy on the Blood Pressure Control among Hypertensive Patients Attending Campus’ Teaching Hospital of Lome, Togo, West Africa
University of Lome, Mixed Faculty of Medicine and Pharmacy, Lome, Togo
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University of Lome, Mixed Faculty of Medicine and Pharmacy, Lome, Togo
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University of Lome, Mixed Faculty of Medicine and Pharmacy, Lome, Togo
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University of Lome, School of Medical Assistants, Lome, Togo;
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University of Lome, Mixed Faculty of Medicine and Pharmacy, Lome, Togo
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University of Ouagadougou, UFR/SOH, Laboratory of Pharmacology/Toxicology, Ouagadougou, Burkina Faso
1 University of Lome, Mixed Faculty of Medicine and Pharmacy, Lome, Togo
2 University of Lome, Mixed Faculty of Medicine and Pharmacy, Lome, Togo
3 University of Lome, Mixed Faculty of Medicine and Pharmacy, Lome, Togo
4 University of Lome, School of Medical Assistants, Lome, Togo;
5 University of Lome, Mixed Faculty of Medicine and Pharmacy, Lome, Togo
6 University of Ouagadougou, UFR/SOH, Laboratory of Pharmacology/Toxicology, Ouagadougou, Burkina Faso
High blood pressure (HBP) is a health problem world—wide. In Togo, that affection constitutes a more and more pre-occupying cause of morbidity and mortality. This study is a prospective one which intended to identify the antihypertensive regimens prescribed and evaluate their effect on patients’ blood pressure (BP) control. Out of the 204 patients enrolled (mean: 55.01 ± 12.55 years; sex ratio: 1.3), 112/176 placed on antihypertensive therapy have controlled their BP (38.39% outpatients vs 61.61% inpatients). Related to the sex factor, we didn’t observe any significant difference in the BP control. Whereas, the mean median value of BP reduction of outpatients (30.00/15.00 mmHg) (p = 0.001) was half lower than that of inpatients (60.00/30.00 mmHg (p = 0.004)). Thirty five outpatients (81.40%) vs 64 inpatients (92.75%) were placed on combination therapy. The bitherapy was prescribed to 23 outpatients (53.49%) against 27 inpatients (39.13%) while the quadritherapy and more than 4 drugs combination were prescribed exclusively to inpatients (20.29%, n = 14). That quadritherapy induced a significant mean reduction of inpatients’ SBP compared to monotherapy (p = 0.043) and to bitherapy (p = 0.004). The favorite combinations were D + CCA, D + ACEI, D + CCA + ACEI and D + CCA + ACEI + CAAD of which the quadruple therapy showed a significant inpatients’ DBP control (p = 0.015) compared to D + CCA combination. The combinations including at least one diuretic induced a significant difference between outpatients (median value: 30.000/10.000 mmHg) (p ＜ 0.001) and inpatients (median value: 60.000 mmHg/30 mmHg) (p ＜ 0.001). The first-line molecules and fixe combinations prescribed in decreasing frequency were among others: hydrochlorothiazide + captopril, nicardipine, α methyldopa for outpatients; furosemide, nicardipine, captopril, α methyldopa, hydrochlorothiazide + captopril for inpatients. Diuretics, CCAs and ACEIs were the 3 favorite pharmacological groups for essential hypertension management in our African resource limited context. Combined to CAAD, they represented the best quadruple combination among inpatients having showed a significant difference in DBP control compared to D + CCA combination.
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Effect of Antihypertensive Drug Therapy on the Blood Pressure Control among Hypertensive Patients Attending Campus’ Teaching Hospital of Lome, Togo, West Africa — Oak Academic Publishing
Monotherapy
Bitherapy
Tritherapy
Quadritherapy
CHU-Campus
Togo
West Africa
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