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Gold Nanoparticles/Carbon Nanotubes Composite Film Modified Glassy Carbon Electrode Determination of Meclofenoxate Hydrochloride
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China;
School of Chemistry and Environment, South China Normal University, Guangzhou, China.
School of Chemistry and Environment, South China Normal University, Guangzhou, China.
- 1 School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China;
- 2 School of Chemistry and Environment, South China Normal University, Guangzhou, China.
- 3 School of Chemistry and Environment, South China Normal University, Guangzhou, China.
Pharmacology & Pharmacy·Volume 03 (2012)·Pages 275–280·Published 4 July 2012·DOI10.4236/pp.2012.33036
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Abstract
A novel voltammetric sensor based on gold nanoparticles (GNPs) and single-walled carbon nanotubes (SWNTs) composite was developed. The nanocomposite modified electrode was characterized using atoms force microscope (AFM). The electrochemical behavior of meclofenoxate hydrochloride (MFX) was investigated on this sensor. The results indicated that the GNPs/SWNTs modified electrode exhibited efficient electrocatalytic oxidation for MFX with relatively high sensitivity, and stability. Using square wave voltammetry (SWV), the GNPs/SWNTs modified electrode exhibited a linear voltammetric response for MFX in the concentration range of 5.0 × 10 –7 – 2.0 × 10 –5 mol·L –1 , with the limit of detection (LOD) of 1.0 × 10 –7 mol·L –1 . The sensor was applied to determine MFX in finished drug with a satisfactory result.
KeywordsMeclofenoxate HydrochlorideSWNTsGold NanoparticlesSquare Wave Voltammetry
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