Effect of Cyclooxygenase-2 Blockade on Renal Hypertrophy Development during Early Diabetes Mellitus — Oak Academic Publishing
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Effect of Cyclooxygenase-2 Blockade on Renal Hypertrophy Development during Early Diabetes Mellitus
Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
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Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
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Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
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Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México DF, México
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Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
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Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
1 Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
2 Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
3 Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
4 Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México DF, México
5 Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
6 Laboratorio de Farmacología, Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación, Facultad de Estudios Superiores Iztacala (FESI), Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, México
Diabetes mellitus is the leading cause of diabetic nephropathy; the early phase of diabetes is associated with kidney growth and hyperfiltration; several factors modulate these changes, among them, prostaglandins and angiotensin II. Previous studies have shown that cyclooxygenase-2 is implicated in experimental models of diabetes. The aim of this work was to study the effect of celecoxib treatment on renal hypertrophy development in early diabetes mellitus. In our rats with early streptozotocin-induced diabetes there was renal hypertrophy, and increased renal expression of cyclooxygenase-2, AT 1 receptor, and transforming growth factor- β 1 . Treatment with the selective cyclooxygenase-2 inhibitor celecoxib reduced the urinary excretion of prostaglandins such as prostaglandin E 2 , 6-keto prostaglandin F 1 α , and thromboxane B 2 . Kidney hypertrophy was reversed by the treatment, and the renal expression of cyclooxygenase-2, AT 1 receptor, and transforming growth factor- β 1 decreased. The renoprotective effects of celecoxib were independent of the changes in plasma glucose levels. These results confirm that cyclooxygenase-2 inhibition in rats with streptozotocin-induced diabetes decrease renal hypertrophy; this effect in turn, may be mediated by reduction of the expression of AT 1 receptors and transforming growth factor- b 1 in the kidney.
KeywordsCOX-2ProstaglandinsTGF-<i>β</i>Diabetic NephropathyRenal HypertrophyAngiotensin II
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