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Microwave Assisted Synthesis and Evaluation of Cross-Linked Carboxymethylated Sago Starch as Superdisintegrant
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Pharmacology & Pharmacy·Volume 02 (2011)·Pages 42–46·Published 19 January 2011·DOI10.4236/pp.2011.21005
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Abstract
The aim of this study was to modify the sago starch and evaluate its efficacy as tablet disintegrant. Cross-linked car-boxymethylated sago starch (CMSS) was synthesized using native sago starch (SS) and monochloroacetic acid (MCA) with sodium hydroxide in microwave radiation environment. FT-IR analysis of the sample confirmed the carboxy-methylation by showing absorption peak at 1607.2 cm-1. CMSS with degree of substitution (DS) of 0.31 was formed and, it was further evaluated as disintegrant in Ondasetron based tablets. The results revealed that CMSS could be used as disintegrant in tablet formulation in concentration dependant manner.
KeywordsSago StarchCarboxymethylationDisintegrantSEMFT-IR
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