The Pharmacodynamic Study of Qin Bing Eye Drop on Photokeratoconjunctivitis
- 1 Department of Pharmacy, Longhua Hospital, Shanghai, China;
- 2 National Medical Department, Youjiang Medical University for Nationalities, Baishe, China
- 3 Department of Surgery, Pudong Hospital, Shanghai, China
- 4 Department of Pharmacy, Longhua Hospital, Shanghai, China;
Abstract
Background: Qin Bing eye drop is prepared with cortex fraxini and borneol. It has been commonly used to relieve the symptoms of photokeratoconjunctivitis (PKC), chronic conjunctivitis and keratitis for more than forty years. However, the origins of cortex fraxini are various, which may result in the unstable quality. Methods: The animal model of PKC was established using rabbit’s eyes exposure to Ultraviolet (UV); levofloxaxin drop, normal saline, Qin Bing eye drops made of herbs from Hebei province and Shanxi province were respectively instilled to both eyes of rabbits; the symptoms of rabbits’ eyes were observed at different time points and scores based on weights were recorded; the recovery rates of different groups were evaluated. Results: The scores of both eyes for all rabbits were above 9 points, indicating animal models for PKC were successful; the average recovery rates of therapeutic groups, including Qin Bing eye drop groups, were higher than untreated group at different time points; the slopes of recovery rate in Qin Bing eye drop (Hebei) were above Shanxi. Conclusion: PKD animal model can be established successfully; Qin Bing eye drop groups promoted the symptoms of PKD recovering quicker than untreated group. Furthermore, Qin Bing eye drop made of herbs from province Hebei had better effects than Shanxi, which was consistent with chemical results. This indicated that chemical constituents of herbs were able to reflect the effects to a certain extent.
- National Commission of Chinese Pharmacopoeia, “Pharmacopoeia of People's Republic of China,” Chemical Industry Press, Beijing, 2010, p. 254.
- L. J. Wang, F. Sun, X. Y. Zhang, et al., “A Secoiridoid with Quinone Reductase Inducing Activity from Cortex fraxini,” Fitoterapia, Vol. 81, No. 7, 2010, pp. 834-837. doi:10.1016/j.fitote.2010.05.003
- X. L. Wei, C. H. Yang and J. Y. Liang, “Constituents of the Barks of Fraxinus chinensis Roxb,” China Journal of National Medicine, Vol. 3, No. 4, 2005, pp. 228-230.
- P. Lu and M. F. Li, “Clinical Observation of ‘Qinpi Eye Drop’ for Chronic Conjunctivitis,” Shanghai Journal of Traditional Chinese Medicine, Vol. 36, No. 9, 2002, pp. 29-31.
- Q. H. Zhao, X. Zhou, R. F. Xie and Z. C. Li, “Comparison of Three Weighing Methods for Evaluation of the HPLC Fingerprints of Cortex fraxini,” Journal of Liquid Chromatography & Related Technologies, Vol. 34, No. 17, 2011, pp. 2008-2019. doi:10.1080/10826076.2011.582912
- H. J. Han, “Clinical Analysis on 127 Cases of Photokeratoconjunctivitis,” Chinese Journal of Ocular Trauma & Occupational Eye Disease, Vol. 29, No. 4, 2007, pp. 309-310.
- O. Tsuyomu, O. Jun and S. Hiroyuki, “Ultraviolet Radiation Emitted by CO2 Arc Welding,” The Annals of Occupational Hygiene, Vol. 45, No. 7, 2001, pp. 597-601.
- D. P. Zhang, S. L. Chen and S. X. Su, “The Animal Experimental Study of Fang Zhi-Ling Eye Drop on Electric Ophthalmia,” Journal of Health Toxicology, Vol. 8, No. 2, 1994, pp. 105-106.
- Y. L. Yen, H. L. Lin, H. J. Lin, et al., “Photokeratoconjunctivitis Caused by Different Light Sources,” The American Journal of Emergency Medicine, Vol. 22, No. 7, 2004, pp. 511-515. doi:10.1016/j.ajem.2004.08.003
- Y. Ding, Y. L. Li and G. Ma, “Integrating Treatment in Patients with Electric Ophthalmia,” Chinese Journal of Today’s Medicine, Vol. 4, No. 5, 2004, pp. 5-6.
- L. Zhou, J. Kang, F. Li, et al., “Simultaneous Analysis of Coumarins and Secoiridoids in Cortex fraxini by HighPerformance Liquid Chromatography-Diode Array Detection-Electrospray Ionization Tandem Mass Spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 47, No. 1, 2008, pp. 39-46. doi:10.1016/j.jpba.2007.12.009