Investigate Evaluation of Oxidative Stress and Lipid Profile in STZ-Induced Rats Treated with Antioxidant Vitamin — Oak Academic Publishing
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Investigate Evaluation of Oxidative Stress and Lipid Profile in STZ-Induced Rats Treated with Antioxidant Vitamin
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia
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Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia
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Department of Public Health, Health Sciences College at Al-lieth, Umm Al Qura University, Makkah, Saudi Arabia; Department of Histopathology and Cytology, College of Medical La-boratory Science, Sudan University of Science and Technology, Khartoum, Sudan
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Department of Pharmaceuticalchemistry, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia
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Veterinary Research Institute, Department of Pharmacology, Khartoum, Sudan
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Veterinary Research Institute, Department of Biochemistry, Khartoum, Sudan
1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia
2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia
3 Department of Public Health, Health Sciences College at Al-lieth, Umm Al Qura University, Makkah, Saudi Arabia; Department of Histopathology and Cytology, College of Medical La-boratory Science, Sudan University of Science and Technology, Khartoum, Sudan
4 Department of Pharmaceuticalchemistry, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia
5 Veterinary Research Institute, Department of Pharmacology, Khartoum, Sudan
6 Veterinary Research Institute, Department of Biochemistry, Khartoum, Sudan
The objective of this study was designed to investigate, evaluate the effect of vitamin E on strepto zotocin (STZ) - induced diabetic rats by show ing significant changes in blood glucose, water, food intake, lipid profile, serum urea and ceratinine level, and antioxidant enzyme parameters activi ty. Streptozotocin (STZ) - induced toxicity was studied in male Waster rats ; each divided into four groups: G1, GII, GIII, and GIV. Control rats GI, rats treated with vitamin E (GII), STZ - induced di abetic rats (GIII), and STZ - induced diabetic rats treated with vitamin E (G1V). Moreover , vitamin E reduced (p < 0.05) blood glucose and urea, thus, our study improved the lipid profile (reduced the serum levels o f amount of total cholesterol, LDL, VLDL, cholesterol and triacyglycerols, and increased HDL cholesterol) and increased total amount protein in STZ-induced diabetic rats (GIV). Vitamin prevented modification in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSX - Px) and in the concentration of the lipid hydroperoxide. Finally the study suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ - induced diabetic rats.
KeywordsInvestigateLipidProfileSTZOxidative StressVitamin E
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