Factors Affecting Medication Non Adherence in Type 2 Sudanese Diabetic Patients
- 1 Departement of Pharmacology, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan
- 2 Clinical Pharmacist, Drug Information and Poisons Centre, Omdurman Teaching Hospital, Omdurman, Sudan
- 3 Departement of Medicine, Faculty of Medicine, University of National Ribat, Khartoum, Sudan
- 4 Continuous Professional Development Directorate, Ministry of Health, Wadmadani, Sudan
Abstract
Background: Medications non-adherence is responsible for treatment failure and a reason of higher cost of medical care. It had been proved that, in general, diabetic patients are non-adherent to their treatment and only a small number of them were found to be adhering with all aspects of diabetic care. Objectives: To assess and evaluate the most common factors associated with medications adherence among Type 2 Diabetes Mellitus (DM) patients attending Ribat University Hospital Diabetic Clinic (RUHDC) Khartoum state, Sudan. Methods: Single Centre Descriptive cross sectional hospital based study was carried out among 351 patients using structured questionnaire and patients cards. Results: A total of 351 patients were recruited in the study; 65.8% were females. About 64.4% were on oral medications and 35.6% on insulin. Adherence to medications among total Type 2 DM patients was 45%. Main barriers to medication adherence were drugs unavailability (34.3%) and forgetfulness (30.7%). Medications knowledge was 41.2% for patients on oral medications and 38.4% for insulin users. Conclusion: Adherence to anti-diabetic drugs in this study was found to be sub-optimal but considered reasonable in comparison with that reported by many African countries. Poor medications knowledge, drug brand unavailability and forgetfulness were the main reasons for medications non adherence. Family support, improving healthcare system and changing patents’ behavior will be needed to improve medications adherence.
- Inzucchi, S.E., et al. (2012) Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care, 35, 1364-1379. http://dx.doi.org/10.2337/dc12-0413
- (2016) Standards of Medical Care in Diabetes-2016: Summary of Revisions. Diabetes Care, 39, S4-S5. http://dx.doi.org/10.2337/dc16-S003
- WHO (2003) Adherence to Long-Term Therapies Evidence for Action.
- Vermeire, E., et al. (2005) Interventions for Improving Adherence to Treatment Recommendations in People with Type 2 Diabetes Mellitus. Cochrane Database of Systematic Reviews, 2, Article ID: CD003638. http://dx.doi.org/10.1002/14651858.cd003638.pub2
- Ose, D., Miksch, A., Urban, E., Natanzon, I., Szecsenyi, J., Kunz, C.U. and Freund, T. (2011) Health Related Quality of Life and Comorbidity. A Descriptive Analysis Comparing EQ-5D Dimensions of Patients in the German Disease Management Program for Type 2 Diabetes and Patients in Routine Care. BMC Health Services Research, 11, 179. http://dx.doi.org/10.1186/1472-6963-11-179
- The Diabetes Control and Complications Trial Research Group (1993) The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus. The New England Journal of Medicine, 329, 977-986. http://dx.doi.org/10.1056/NEJM199309303291401
- Farsaei, S., et al. (2011) Effect of Pharmacist-Led Patient Education on Glycemic Control of Type 2 Diabetics: A Randomized Controlled Trial. Journal of Research in Medical Sciences, 16, 43-49.
- Ho, P.M., Rumsfeld, J.S., Masoudi, F.A., McClure, D.L., Plomondon, M.E., Steiner, J.F. and Magid, D.J. (2006) Effect of Medication Non-Adherence on Hospitalization and Mortality among Patients with Diabetes Mellitus. Archives of Internal Medicine, 166, 1836-1841. http://dx.doi.org/10.1001/archinte.166.17.1836
- Chatterjee, J.S. (2006) From Compliance to Concordance in Diabetes. Journal of Medical Ethics, 32, 507-510. http://dx.doi.org/10.1136/jme.2005.012138
- Rubin, R.R. (2005) Adherence to Pharmacologic Therapy in Patients with Type 2 Diabetes Mellitus. The American Journal of Medicine, 118, 27S-34S. http://dx.doi.org/10.1016/j.amjmed.2005.04.012
- Horton, E.S. (2008) Can Newer Therapies Delay the Progression of Type 2 Diabetes Mellitus? Endocrine Practice, 14, 625-638. http://dx.doi.org/10.4158/EP.14.5.625