<i>In vitro</i> Antibacterial Activity of Bioactive Potent Compounds from <i>Terminalia chebula</i> against Some Common Human Pathogens
- 1 Department of Clinical & Experimental Pharmacology, School of Tropical Medicine, Kolkata, India
- 2 Department of Clinical & Experimental Pharmacology, School of Tropical Medicine, Kolkata, India
- 3 Department of Clinical & Experimental Pharmacology, School of Tropical Medicine, Kolkata, India
Abstract
Objective: Emergence of community-acquired infections due to multi drug resistant (MDR) common human pathogens have caused a great problem to clinicians and this directed us to search systematically for a different remedy with compounds particularly from plant origin. Methods: The antibacterial activity was evaluated using agar well diffusion assay method against some common gram positive and gram negative bacteria. Results: In vitro study with Terminalia chebula Retz. (Combretaceae) stem bark extracts, eight isolated triterpenoids and four triterpenoid derivatives were found to be effective against Bacillus subtilis , Staphylococcus aureus , Salmonella typhi , Pseudomonas aeruginosa and Escherichia coli . Conclusions: Pure compounds from T.chebula could be effectively used as antibacterial agents if it is possible to develop the molecules synthetically. At the same time crude extracts with specified active principles could also be used and/or introduced in Traditional Medicine/Complementary Alternative Medicine (TM/CAM) as antibacterial into National/International Health Systems as per the guideline of Ayurvedic formularies.
- Marr, C. and Bent, S. (1999) An Evidence Based Review of the 10 Most Commonly Used Herbs. Western Journal of Medicine, 171, 168-171.
- Cragg, G.M. and Newman, D.J. (2013) Natural Products: A Continuing Source of Novel Drug Leads. Biochimica et Biophysica Acta, 1830, 3670-3695. https://doi.org/10.1016/j.bbagen.2013.02.008
- Che, C.T., Wang, Z.J., Chow, M.S. and Lam, C.W. (2013) Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives. Molecules, 18, 5125-5141. https://doi.org/10.3390/molecules18055125
- Khatri, S., Kumar, M., Phougat, N., Chaudhary, R. and Chhillar, A.K. (2016) Perspectives on Phytochemicals as Antibacterial Agents: An Outstanding Contribution to Modern Therapeutics. Mini-Reviews in Medicinal Chemistry, 16, 290-308. https://doi.org/10.2174/138955751604160201150438
- Pan, S.Y., Gao, S.H., Zhou, S.F., et al. (2012) New Perspectives on Complementary and Alternative Medicine: an Overview and Alternative Therapy. Alternative Therapies in Health and Medicine, 18, 20-36.
- Nature (2013) The Antibiotic Alarm. Nature, 495, 141. https://doi.org/10.1038/495141a
- Piddock, L.J. (2012) The Crisis of No New Antibiotics—What Is the Way Forward? The Lancet Infectious Diseases, 12, 249-253. https://doi.org/10.1016/S1473-3099(11)70316-4
- Lee, V.C. (2015) The Antibiotic Resistance Crisis: Part 1: Causes and Threats. Pharmacy and Therapeutics, 40, 277.
- Savoia, D. (2012) Plant-Derived Antimicrobial Compounds: Alternatives to Antibiotics. Future Microbiology, 7, 979-990. https://doi.org/10.2217/fmb.12.68
- González-Lamothe, R., Mitchell, G., Gattuso, M., Diarra, M.S., Malouin, F. and Bouarab, K. (2009) Plant Antimicrobial Agents and Their Effects on Plant and Human Pathogens. International Journal of Molecular Sciences, 10, 3400-3419. https://doi.org/10.3390/ijms10083400
- Dixon, R.A. (2001) Natural Products and Plant Disease Resistance. Nature, 411, 843-847. https://doi.org/10.1038/35081178
- Chadha, Y.R. (1976) The Wealth of India. Vol. 10, Council of Scientific and Industrial Research, New Delhi, 164.
- Cheng, H.Y., Lin, T.C., Yu, K.H., Yang, C.M. and Lin, C.C. (2003) Antioxidant and Free Radical Scavenging Activities of Terminalia chebula. Biological and Pharmaceutical Bulletin, 26, 1331-1335. https://doi.org/10.1248/bpb.26.1331