Crisaborole and Apremilast: PDE4 Inhibitors with Similar Mechanism of Action, Different Indications for Management of Inflammatory Skin Conditions — Oak Academic Publishing
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Crisaborole and Apremilast: PDE4 Inhibitors with Similar Mechanism of Action, Different Indications for Management of Inflammatory Skin Conditions
Kitzen Pharmaceutical Consulting, Collegeville, PA, USA
,
Temple University School of Medicine, Philadelphia, PA, USA
,
Neumentum, Inc., Palo Alto, CA, USA
,
NEMA Research, Inc., Naples, FL, USA
,
University of Arizona College of Pharmacy, Tucson, AZ, USA
,
Temple University School of Pharmacy, Philadelphia, PA, USA
1 Kitzen Pharmaceutical Consulting, Collegeville, PA, USA
2 Temple University School of Medicine, Philadelphia, PA, USA
3 Neumentum, Inc., Palo Alto, CA, USA
4 NEMA Research, Inc., Naples, FL, USA
5 University of Arizona College of Pharmacy, Tucson, AZ, USA
6 Temple University School of Pharmacy, Philadelphia, PA, USA
Two selective phosphodiesterase-4 (PDE4) inhibitors—viz., crisaborole (Eucrisa ® , Pfizer) and apremilast (Otezla ® , Celgene)—have recently received approval by the United States Food and Drug Administration for the treatment of related but different dermatologic skin conditions (viz., atopic dermatitis and plaque psoriasis, respectively). The purpose of this review is to summarize the underlying biochemistry and pathophysiology associated with these dermatologic conditions, review the chemistry, pharmacology and safety of each of these products, and present preclinical and clinical evidence that may help explain why these two PDE4 inhibitors offer new treatment options for these skin conditions.
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