Anti-Aging Effect of <i>Cynara cardunculus</i> L. var. <i>Cynara scolymus</i> L. Extract in D-Galactose-Induced Skin Aging Model in Rats — Oak Academic Publishing
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Anti-Aging Effect of <i>Cynara cardunculus</i> L. var. <i>Cynara scolymus</i> L. Extract in D-Galactose-Induced Skin Aging Model in Rats
International Center of Introduction of New Biomedical Technology, Tbilisi, Georgia
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International Center of Introduction of New Biomedical Technology, Tbilisi, Georgia
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International Center of Introduction of New Biomedical Technology, Tbilisi, Georgia
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Department of Pharmacology, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia
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Department of Pharmacy Technology of Federal State Autonomous Educational Institution of Higher Education, I. M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
1 International Center of Introduction of New Biomedical Technology, Tbilisi, Georgia
2 International Center of Introduction of New Biomedical Technology, Tbilisi, Georgia
3 International Center of Introduction of New Biomedical Technology, Tbilisi, Georgia
4 Department of Pharmacology, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia
5 Department of Pharmacy Technology of Federal State Autonomous Educational Institution of Higher Education, I. M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
The aim of the study was to evaluate the efficacy of 2% Cynara scolymus L. extracts in reverse disturbances of collagen metabolism and inflammation in D-galactose induced skin aging model in rats. D-galactose induced aging reproduced in 48 animals of main group, and 12 rats in control group. All animals in main group were randomized for 4 groups: I . aging + saline, II - IV . different manufacturers 2% artichoke extracts (with content of chlorogenic acid < 2.5%) in a dose of intradermal injection 0.13 mg twice at weeks during 4 weeks. Influence of artichoke extracts restored skin relative weight and led to an increase of solubility in neutral salt and acid , and decreased pepsin solubility collagen fraction, restored the hexosamine/collagen (hydroxyproline) ratio and decreased the activity of nuclear transcription factor (NF-kB). Local prolonged treatment with artichoke extracts improved collagen metabolism and attenuated the progression of inflammation in D-galactose induced skin aging model.
KeywordsSkinAgingCollagenPure Water <i>Cynara cardunculus</i>L. var. <i>Cynara scolymus</i>L. ExtractNuclear Transcription Factor Kappa B
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