A Review on Ethnomedicinal, Pharmacological, Phytochemical and Pharmaceutical Profile of Lady’s Finger (<i>Abelmoschus esculentus</i> L.) Plant — Oak Academic Publishing
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A Review on Ethnomedicinal, Pharmacological, Phytochemical and Pharmaceutical Profile of Lady’s Finger (<i>Abelmoschus esculentus</i> L.) Plant
Department of Pharmacy, Manarat International University, Dhaka, Bangladesh
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Department of Pharmacy, Manarat International University, Dhaka, Bangladesh
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Department of Pharmacy, Manarat International University, Dhaka, Bangladesh
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Biological Research Division, BCSIR Laboratories, Dhaka, Bangladesh
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Biological Research Division, BCSIR Laboratories, Dhaka, Bangladesh
1 Department of Pharmacy, Manarat International University, Dhaka, Bangladesh
2 Department of Pharmacy, Manarat International University, Dhaka, Bangladesh
3 Department of Pharmacy, Manarat International University, Dhaka, Bangladesh
4 Biological Research Division, BCSIR Laboratories, Dhaka, Bangladesh
5 Biological Research Division, BCSIR Laboratories, Dhaka, Bangladesh
Abelmoschus is a genus of about fifteen species belongs to the family Malvaceae. The herb, popularly known as Lady’s Finger or Okra (in English) is a nutritional source used for both medicinal and culinary purposes. The plant is widely distributed from Africa to Asia, Southern Europe, and America. This comprehensive account provides a botanical description of the plant, its phytochemical constituents and pharmacological activities focusing anti-diabetic, anti-oxidant, anti-adhesive, gastro-protective, hepatoprotective, and immunomodulating actions. Most of the pharmacological effects can be explained by the constituents like tannins, terpenoids, flavonoids and glycosides present in all plant parts. However, future efforts should concentrate more on in vitro and in vivo studies and also on clinical trials in order to confirm traditional wisdom in the light of a rational phytotherapy. The present review is an overview of phytochemistry and ethnopharmacological studies that support many of the traditional ethnomedicinal uses of the plant.
Panadda, K., Walairorn, T., Noppakun, P., Maitree, S. and Piyanete, C. (2010) Antioxidative Activities and Phenolic Content of Extracts from Okra (Abelmoschus esculentus L.). Research Journal of Biological Sciences, 5, 310-313. https://doi.org/10.3923/rjbsci.2010.310.313
Doreddula, S.K., Bonam, S.R., Gaddam, D.P., Desu, B.S., Ramarao, N. and Pandy, V. (2014) Phytochemical Analysis, Antioxidant, Antistress and Nootropic Activities of Aqueous and Methanolic Seed Extracts of Ladies Finger (Abelmoschus esculentus L.) in Mice. Scientific World Journal, 2014, Article ID: 519848. https://doi.org/10.1155/2014/519848
Hu, L., Yu, W., Li, Y., Prasad, N. and Tang, Z. (2014) Antioxidant Activity of Extract and Its Major Constituents from Okra Seed on Rat Hepatocytes Injured by Carbon Tetrachloride. BioMed Research International, 2014, Article ID: 341291.
Kumar, S. and Dagnoko, S. (2010) A Review on Okra (Abelmoschus spp.) in West and Central Africa: Potential and Progress on Its Improvement. African Journal of Agriculture Research, 5, 3590-3598.
Arapitsas, P. (2008) Identification and Quantification of Polyphenolic Compounds from Okra Seeds and Skins. Food Chemistry, 110, 1041-1045. https://doi.org/10.1016/j.foodchem.2008.03.014
Saifullah, M. and Rabbani, M.G. (2009) Evaluation and Characterization of Okra (Abelmoschus esculentus L. Moench.) Genotypes. SAARC Journal of Agriculture, 7, 91-98.
Purseglove, J.W. (1987) Tropical Crop Dicotyedons. Language Book Sosiety Longman, London.
Benjawan, C., Chutichudet, P. and Kaewsit, S. (2007) Effect of Green Manures on Growth Yield and Quality of Green Okra (Abelmoschus esculentus L.) Har Lium Cultivar. Pakistan Journal Biological Science, 10, 1028-1035. https://doi.org/10.3923/pjbs.2007.1028.1035
Qhureshi, Z. (2007) Breeding Investigation in Bhendi (Abelmoschus esculentus (L.) Moench). Master Thesis, University of Agriculture Sciences, GKVK, Bangalore.
Roy, A., Shrivastava, S.L. and Mandal, S.M. (2014) A Review on Functional Properties of Okra (Abelmoschus esculentus L. (Moench)): Traditional Claims and Scientific Evidences. Plant Science Today, 1, 121-130. https://doi.org/10.14719/pst.2014.1.3.63
Torkpo, S.K., Danquah, E.Y., Offei, S.K. and Blay, E.T. (2006) Esterase, Total Protein and Seed Storage Protein Diversity in Okra. West Africa Journal of Applied Ecology, 9, 8-18.
Petropoulos, S., Fernandes, A., Barros, L., Ciric, A., Sokovic, M. and Ferreira, I.C.F.R. (2017) The Chemical Composition, Nutritional Value and Antimicrobial Properties of Abelmoschus esculentus Seeds. Food and Function, 8, 4733-4743. https://doi.org/10.1039/C7FO01446E
Moyin-Jesu, E.I. (2007) Use of Plant Residues for Improving Soil Fertility, Pod Nutrients, Root Growth and Pod Weight of Okra (Abelmoschus esculentus). Bioresource Technology, 98, 2057-2064. https://doi.org/10.1016/j.biortech.2006.03.007
Adelakun, O.E., Oyelade, O.J. and Ade-Omowaye, B.I. (2009) Influence of Pre- Treatment of Yield Chemical and Antioxidant Properties of Nigerian Okra Seed (Abelmoschus esculentus). Food and Chemical Toxicology, 46, 657-661. https://doi.org/10.1016/j.fct.2008.12.023
Gemede, H.F. and Haki, G.D. (2015) Proximate, Mineraland Anti-Nutrient Compositions of Indigenous Okra (Abelmoschus esculentus) Pod Accessions: Implications for Mineral Bioavailability. Food Science and Nutrition, 4, 223-233. https://doi.org/10.1002/fsn3.282
Odedra, N.K. and Jadeja, B.A. (2012) Ethnobotany of Maher Tribe. 1-459.
Lim, T.K. (2012) Edible Medicinal and Non-Medicinal Plants. Springer Science + Business Media, Berlin, Vol. 3, 160.
Maramag, R.P. (2013) Diuretic Potential of Capsicum frutescens L., Corchorus oliturius L. and Abelmoschus esculentus L. Asian Journal of Natural and Applied Science, 2, 60-69.
Smit, R., Neeraj, K. and Preeti, K. (2013) Traditional Medicinal Plants Used for the Treatment of Diabetes. International Journal of Pharmaceutical and Phyto-Pharma- cological Research, 3, 171-175.
Sayana, S.B. and Khanwelkar, C.K. (2014) Evaluation of Diuretic Activity of Alcoholic Extract of Roots of Cissampelos pareira in Albino Rats. Journal of Clinical and Diagnostic Research, 8, 1-4. https://doi.org/10.7860/JCDR/2014/8192.4350
Babu, P.S. and Srinivasan, K. (1995) Influence of Dietary Curcumin and Cholesterol on the Progression of Experimentally Induced Diabetes in Albino Rat. Molecular and Cellular Biochemistry, 152, 13-21.
Barrett, B. (1994) Medicinal Plants of Nicaragua’s Atlantic Coast. Economic Botany, 481, 8-20. https://doi.org/10.1007/BF02901375
Crossley, A. and Hilditch, T.P. (1951) The Fatty Acids and Glycerides of Okra Seed Oil. Journal of the Science of Food and Agriculture, 2, 251-255. https://doi.org/10.1002/jsfa.2740020604
Martin, F.W. (1982) Okra, Potential Multiple-Purpose Crop for the Temperate Zones and Tropics. Economic Botany, 36, 340-345. https://doi.org/10.1007/BF02858558
Vaidya, M.V. and Nanoti, M.V. (1989) Bhindi Seed Powder as Coagulant in Removal of Turbidity from Water. Indian Journal of Environmental Health, 31, 43-48.
Calisir, S., Ozcan, M., Haciseferogullari, H. and Yildiz, M.U. (2005) A Study on Some Physico-Chemical Properties of Turkey Okra (Hibiscus esculentus) Seeds. Journal of Food Engineering, 68, 73-78. https://doi.org/10.1016/j.jfoodeng.2004.05.023
Jarret, R.L., Wang, M.L. and Levy, I.J. (2011) Seed Oil and Fatty Acid Content in Okra (Abelmoschus esculentus) and Related Species. Journal of Agricultural and Food Chemistry, 59, 19-24. https://doi.org/10.1021/jf104590u
Marwat, S.K., Rehman, F.R. and Khan, M.A. (2011) Medicinal Folk Recipes Used as Traditional Used as Traditional Phytotherapies. Journal of Botany, 43, 1453-1462.
Huang, Z., Wang, B. and Eaves, D.H. (2007) Phenolic Compound Profile of Selected Vegetables Frequently Consumed by African Americans in the Southeast United States. Food and Chemical Toxicololy, 103, 1359-1402. https://doi.org/10.1016/j.foodchem.2006.10.077
Honda, A.H., Nakagawa, S., Ashida, H. and Kanazawa, K. (2003) Simultaneous Determination of All Polyphenols in Vegetables, Fruits and Teas. Journal of Agriculture and Food Chemistry, 51, 571-581.
Male, A. and Grandhi, S. (2017) A Phytopharmacological Review on Abelmoschus esculentus L. European Journal of Biomedical and Pharmaceutical Science, 4, 775-780.
Saravanan, S. and Pandikumar, P. (2013) Hepatoprotective Role of Abelmoschus esculentus (L.) Moench., on Carbon Tetrachloride-Induced Liver Injury. Toxicology Mechanism and Methods, 23, 528-536.
Fan, S., Zhang, Y. and Sun, Q. (2014) Extract of Okra Lowers Blood Glucose and Serum Lipids in High Fat Diet-Induced Obese C57BL/6 Mice. Journal of Nutritional Biochemistry, 125, 702-709. https://doi.org/10.1016/j.jnutbio.2014.02.010
Zhou, Y., Jia, X., Shi, J., Xu, Y., Jing, L. and Jia, L. (2013) Two New Pentacyclic Triterpenes from Abelmoschus esculentus. Helvetica Chimica Acta, 96, 533-537. https://doi.org/10.1002/hlca.201200275
Lin, Y., Liu, H.L., Fang, J., Yu, C.H., Xiong, Y.K. and Yuan, K. (2014) Anti-Fatigue and Vaso-Protective Effects of Quercetin-3-O-Gentiobiose on Oxidative Stress and Vascular Endothelial Dysfunction Induced by Endurance Swimming in Rats. Food and Chemical Toxicology, 68, 290-296. https://doi.org/10.1016/j.fct.2014.03.026
Kobori, M., Takahashi, Y., Akimoto, Y., Sakurai, M., Matsunaga, I., Nishimuro, H., Ippoushi, K., Oike, H. and Ohnishi-Kameyama, M. (2015) Chronic High Intake of Quercetin Reduces Oxidative Stress and Induces Expression of the Antioxidant Enzymes in the Liver and Visceral Adipose Tissues in Mice. Journal of Functional Foods, 15, 551-560. https://doi.org/10.1016/j.jff.2015.04.006
Xia, F., Zhong, Y., Li, M. and Chang, Q. (2015) Anti-Oxidant and Anti-Fatigue Constituents of Okra. Nutrients, 7, 8846-8858. https://doi.org/10.3390/nu7105435
Ortaç, D., Cemek, M., Karaca, T., Buyukokuroglu, M.E., Ozdemir, Z.O., Kocaman, A.T. and Gones, S. (2018) In Vivo Anti-Ulcerogenic Effect of Okra (Abelmoschus esculentus) on Ethanol-Induced Acute Gastric Mucosal Lesions. Pharmaceutical Biology, 56, 165-175. https://doi.org/10.1080/13880209.2018.1442481
Ribeiro, K.A., Chaves, H.V. and Filho, S.M. (2016) Αlpha-2 Adrenergic and Opioids Receptors Participation in Mice Gastroprotection of Abelmoschus esculentus Lectin. Current Pharmaceutical Design, 22, 4736-4742. https://doi.org/10.2174/1381612822666160201152438
Tongjaroenbuangam, W., Ruksee, N., Chantiratikul, P., Pakdeenarong, N., Kongbuntad, W. and Govitrapong, P. (2011) Neuroprotective Effects of Quercetin, Rutin and Okra (Abelmoschus esculentus Linn.) in Dexamethasonetreated Mice. Neurochemistry International, 59, 677-685.
Mathew, M. and Subramanian, S. (2014) In Vitro Screening for Anticholinesterase and Antioxidant Activity of Methanolic Extracts of Ayurvedic Medicinal Plants Used for Cognitive Disorders. PLoS ONE, 9, e86804.
Mairuae, N., Connor, J.R., Lee, S.Y., Cheepsunthorn, P. and Tongjaroenbuangam, W. (2015) The Effects of Okra (Abelmoschus esculentus Linn.) on the Cellular Events Associated with Alzheimer’s Disease in a Stably Expressed HFE Neuroblastoma SH-SY5Y Cell Line. Neuroscience Leterst, 603, 6-11. https://doi.org/10.1016/j.neulet.2015.07.011
Mairuae, N., Cheepsunthorn, P., Cheepsunthorn, C.L. and Tongjaroenbuangam, W. (2017) Okra (Abelmoschus esculentus Linn) Inhibits Lipopolysaccharide-Induced Inflammatory Mediators in BV2 Microglial Cells. Tropical Journal of Pharmaceutical Research, 16, 1285-1292. https://doi.org/10.4314/tjpr.v16i6.11
Rakesh, K., Sindhu and Vishal, P. (2016) Phytochemical, Nutritional and Pharmacological Evidences for Abelmoschus esculentus (L.). The Journal of Phytopharmacology, 5, 238-241.
Mairuae, N., Connor, J.R. and Lee, S.Y. (2015) The Effects of Okra (Abelmoschus esculentus L.) on the Cellular Events Associated with Alzheimer’s Disease in a Stably Expressed HFE Neuroblastoma SH-SY5Y Cell Line. Neuroscience Letters, 31, 603-611. https://doi.org/10.1016/j.neulet.2015.07.011
Ngoc, T.H., Ngo, Q.N., Van, A.T.T. and Phung, N.V. (2008) Hypolipidemic Effect of Extracts from Abelmoschus esculentus L. (Malvaceae) on Tyloxapol-Induced Hyperlipidemia in Mice. Journal of Pharmaceutical Science, 35, 42-46.
Vindika, S., Kuruwitaarachchige, D., Inoka, U., Sirimal, P. and Jayantha, W. (2018) Cardio Protective Activity of Abelmoschus esculentus (Okra). International Journal of Food Science and Nutrition, 3, 39-43.
Zheng, W., Zhao, T., Feng, W. and Wang, W. (2014) Purification, Characterization and Immunomodulating Activity of a Polysaccharide from Flowers of Abelmoschus esculentus. Carbohydrate Polymers, 15, 335-342. https://doi.org/10.1016/j.carbpol.2014.02.079
Chen, H., et al. (2016) In Vitro and in Vivo Immunomodulatory Activity of Okra (Abelmoschus esculentus L.) Polysaccharides. Journal of Medicinal Food, 19, 253-265.
Solomon, S., Muruganantham, N. and Senthamilselvi, M.M. (2016) Anticancer Activity of Abelmoschus esculentus (Flowers) against Human Liver Cancer. International Journal of Pharmacy and Biological Science, 6, 154-157. https://doi.org/10.21276/ijpbs.2016.6.3.18
Thole, C., Brandt, S. and Ahmed, N. (2015) Acetylated Rhamnogalacturonans from Immature Fruits of Abelmoschus esculentus Inhibits the Adhesion of Helicobacter pylori to Human Gastric Cells by Interaction with Outer Membrane Proteins. Molecules, 20, 16770-16787. https://doi.org/10.3390/molecules200916770
Messing, J., Thole, C., Niehues, M. and Shevtsova, A. (2014) Antiadhesive Properties of Abelmoschud esculentus (Okra) Immature Fruit Extract against Helicobacter pylori Adhesion. PLoS ONE, 9, e84836.
Zaharuddin, N.D., Noordin, M.I. and Kadivar, A. (2014) The Use of Hibiscus esculentus (Okra) Gum in Sustaining the Release of Propranolol Hydrochloride in a Solid Oral Dosage Form. BioMed Research International, 2014. Article ID: 735891.
Farooq, U., Malviya, R. and Sharma, P.K. (2013) Extraction and Characterization of Okra Mucilage as Pharmaceutical Excipient. Academic Journal of Plant Science, 6, 168-172.
Ghori, M.U., Alba, K., Smith, A.M. and Conway, B.R. (2014) Okra Extracts in Pharmaceutical and Food Application. Food Hydrocolloids, 42, 342-347. https://doi.org/10.1016/j.foodhyd.2014.04.024
Noorlaila, A., Aziah, S.A., Asmeda, R. and Norizzah, A.R. (2015) Emulsifying Properties of Extracted Okra (Abelmoschus esculentus L.) Mucilage of Different Maturity Index and Its Application in Coconut Milk Emulsion. International Food Research Journal, 22, 782-787.
Tavakoli, N., Ghassemi, D.N., Teimouri, R. and Hamishehkar, H. (2008) Characterization and Evaluation of Okra Gum as a Tablet Binder. Jundishapur Journal of Natural Pharmaceutical Products, 3, 33-38.
Pawan, P. and Nitin, K. (2013) Design and Development of Sustained Release Matrix Tablet of Diclofenac Sodium Using Natural Polymer. International Research Journal of Pharmacy, 4, 169-176.