Preparation and Evaluation of Poly-γ-Glutamic Acid Hydrogel Mixtures with Basic Drugs or Acidic Drugs: Effect on Ease of Swallowing and Taste Masking — Oak Academic Publishing
Research ArticleOpen AccessGoogle Scholar indexed
Preparation and Evaluation of Poly-γ-Glutamic Acid Hydrogel Mixtures with Basic Drugs or Acidic Drugs: Effect on Ease of Swallowing and Taste Masking
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
,
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
,
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
,
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
,
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
,
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
,
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
,
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
,
Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
1 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
2 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
3 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
4 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
5 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
6 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
7 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
8 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
9 Faculty of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
The purpose of this study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to examine its ease of swallowing using texture profile analysis (TPA) and to evaluate its taste-masking effects on basic or acidic drugs using the artificial taste sensor. Using TPA, 0.5% and 1.0% PGA gels, 0.5% and 1.0% agar and 1.0% ι-carrageenan in the absence of drug was examined the hardness, adhesiveness and cohesiveness, ranked according to permission criteria published by the Japanese Consumers Affairs Agency. 0.5% PGA gel and 1.0% agar were classified into grade II. In the taste sensor measurement, the bitterness suppressions by 0.5% PGA gel were larger than that by 1.0% agar in all drugs and the bitterness suppressions of basic drugs in 0.5% PGA gel were more potent than those of acidic drugs in 0.5% PGA gel. 1H-nuclear magnetic resonance spectroscopic analysis was carried out to examine the difference in mechanism of bitterness suppression between basic drugs and acidic drugs mixed with PGA gel. The signals of the proton nearest to the nitrogen atom of basic drugs shifted clearly upfield, suggesting an interaction between the amino group of basic drugs and the carboxyl group of PGA gel. In conclusion, PGA gel is expected to be a useful excipient in formulations contained various drugs, especially basic drugs; it also has advantage for not only increasing ease of swallowing but also masking the bitterness of drugs even though a small amount of a single drug dose might be preferred.
Mennella, J.A., Spector, A.C., Reed, D.R. and Coldwell, S.E. (2013) The Bad Taste of Medicines: Overview of Basic Research on Bitter Taste. Clinical Therapeutics, 35, 1225-1246. https://doi.org/10.1016/j.clinthera.2013.06.007
Miyanaga, Y., Inoue, N., Ohnishi, A., Fujisawa, E., Yamaguchi, M. and Uchida, T. (2003) Quantitative Prediction of the Bitterness Suppression of Elemental Diets by Various Flavors Using a Taste Sensor. Pharmaceutical Research, 20, 1932-1938. https://doi.org/10.1023/B:PHAM.0000008039.59875.4f
Mukai, J., Tokuyama, E., Ishizaka, T., Okada, S. and Uchida, T. (2007) Inhibitory Effect of Aroma on the Bitterness of Branched-Chain Amino Acid Solutions. Chemical and Pharmaceutical Bulletin, 55, 1581-1584. https://doi.org/10.1248/cpb.55.1581
Szejtli, J. and Szente, L. (2005) Elimination of Bitter, Disgusting Tastes of Drugs and Foods by Cyclodextrins. European Journal of Pharmaceutics and Biopharmaceutics, 61, 115-125. https://doi.org/10.1016/j.ejpb.2005.05.006
Ono, N., Miyamoto, Y., Ishiguro, T., Motoyama, K., Hirayama, F., Iohara, D., et al. (2011) Reduction of Bitterness of Antihistaminic Drugs by Complexation with β-Cyclodextrins. Journal of Pharmaceutical Sciences, 100, 1935-1943. https://doi.org/10.1002/jps.22417
Kim, J.I., Cho, S.M., Cui, J.H., Cao, Q.R., Oh, E. and Lee, B.J. (2013) In Vitro and in Vivo Correlation of Disintegration and Bitter Taste Masking Using Orally Disintegrating Tablet Containing Ion Exchange Resin-Drug Complex. International Journal of Pharmaceutics, 455, 31-39. https://doi.org/10.1016/j.ijpharm.2013.07.072
Rahman, Z., Zidan, A.S., Berendt, R.T. and Khan, M.A. (2012) Tannate Complexes of Antihistaminic Drug: Sustained Release and Taste Masking Approaches. International Journal of Pharmaceutics, 422, 91-100. https://doi.org/10.1016/j.ijpharm.2011.10.033
Nakamura, T., Tanigake, A., Miyanaga, Y., Ogawa, T., Akiyoshi, T., Matsuyama, K., et al. (2002) The Effect of Various Substances on the Suppression of the Bitterness of Quinine-Human Gustatory Sensation, Binding, and Taste Sensor Studies. Chemical and Pharmaceutical Bulletin, 50, 1589-1593. https://doi.org/10.1248/cpb.50.1589
Ogi, K., Yamashita, H., Terada, T., Homma, R., Shimizu-Ibuka, A., Yoshimura, E., et al. (2015) Long-Chain Fatty Acids Elicit a Bitterness-Masking Effect on Quinine and Other Nitrogenous Bitter Substances by Formation of Insoluble Binary Complexes. Journal of Agricultural and Food Chemistry, 63, 8493-8500. https://doi.org/10.1021/acs.jafc.5b03193
Bohin, M.C., Roland, W.S., Gruppen, H., Gouka, R.J., van der Hijden, H.T., Dekker, P., et al. (2013) Evaluation of the Bitter-Masking Potential of Food Proteins for EGCG by a Cell-Based Human Bitter Taste Receptor Assay and Binding Studies. Journal of Agricultural and Food Chemistry, 61, 10010-10017. https://doi.org/10.1021/jf4030823
Shiraishi, S., Haraguchi, T., Nakamura, S., Li, D., Kojima, H., Yoshida, M., et al. (2017) Taste-Masking Effect of Chlorogenic Acid (CGA) on Bitter Drugs Evaluated by Taste Sensor and Surface Plasmon Resonance on the Basis of CGA-Drug Interactions. Chemical and Pharmaceutical Bulletin, 65, 127-133. https://doi.org/10.1248/cpb.c16-00621
Shiraishi, S., Haraguchi, T., Nakamura, S., Kojima, H., Kawasaki, I., Yoshida, M., et al. (2017) Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid. Chemical and Pharmaceutical Bulletin, 65, 151-156. https://doi.org/10.1248/cpb.c16-00670
Roland, W.S., Gouka, R.J., Gruppen, H., Driesse, M., van Buren, L., Smit, G., et al. (2014) 6-Methoxyflavanones as Bitter Taste Receptor Blockers for hTAS2R39. PLoS ONE, 9, e94451. https://doi.org/10.1371/journal.pone.0094451
Pydi, S.P., Jaggupilli, A., Nelson, K.M., Abrams, S.R., Bhullar, R.P., Loewen, M.C., et al. (2015) Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4. Biochemistry, 54, 2622-2631. https://doi.org/10.1021/acs.biochem.5b00265
Amerman, J.D. and Parnell, M.M. (1990) Auditory Impressions of the Speech of Normal Elderly Adults. British Journal of Disorders of Communication, 25, 35-43. https://doi.org/10.3109/13682829009011961
Ballard, K.J., Robin, D.A., Woodworth, G. and Zimba, L.D. (2001) Age-Related Changes in Motor Control during Articulator Visuomotor Tracking. Journal of Speech, Language, and Hearing Research, 44, 763-777. https://doi.org/10.1044/1092-4388(2001/060)
Wohlert, A.B. and Smith, A. (1998) Spatiotemporal Stability of Lip Movements in Older Adult Speakers. Journal of Speech, Language, and Hearing Research, 41, 41-50. https://doi.org/10.1044/jslhr.4101.41
Bennett, J.W., van Lieshout, P.H. and Steele, C.M. (2007) Tongue Control for Speech and Swallowing in Healthy Younger and Older Subjects. The International Journal of Orofacial Myology, 33, 5-18.
Murakami, S., Aoki, N. and Matsumura, S. (2011) Bio-Based Biodegradable Hydrogels Prepared by Crosslinking of Microbial Poly (γ-Glutamic Acid) with L-Lysine in Aqueous Solution. Polymer Journal, 43, 414-420. https://doi.org/10.1038/pj.2010.142
Tanimoto, H., Mori, M., Motoki, M., Torii, K., Kadowaki, M. and Noguchi, T. (2001) Natto Mucilage Containing Poly-Gamma-Glutamic Acid Increases Soluble Calcium in the Rat Small Intestine. Bioscience, Biotechnology and Biochemistry, 65, 516-521. https://doi.org/10.1271/bbb.65.516
Tanimoto, H., Fox, T., Eagles, J., Satoh, H., Nozawa, H., Okiyama, A., et al. (2007) Acute Effect of Poly-Gamma-Glutamic Acid on Calcium Absorption in Post-Meno-pausal Women. Journal of American College of Nutrition, 26, 645-649. https://doi.org/10.1080/07315724.2007.10719642
Tsuji, E., Uchida, T., Fukui, A., Fujii, R. and Sunada, H. (2006) Evaluation of Bitterness Suppression of Macrolide Dry Syrups by Jellies. Chemical and Pharmaceutical Bulletin, 54, 310-314. https://doi.org/10.1248/cpb.54.310
Kojima, H., Nakamura, S., Haraguchi, T., Yoshida, M., Habara, M., et al. (2019) A New Strategy for Taste Masking on Bitter Drug by Other Combined Drug in Fixed-Dose Combination: Bitterness of Amlodipine Besylate Could Be Masked Efficiently by Valsartan. Journal of Pharmacy and Pharmacology, 71, 1384-1392. https://doi.org/10.1111/jphp.13134
Uchida, T., Sugino, Y., Hazekawa, M., Yoshida, M. and Haraguchi, T. (2012) Factors Affecting the Bitterness Intensities of Ten Commercial Formulations of Ambroxol. Chemical and Pharmaceutical Bulletin, 60, 949-954. https://doi.org/10.1248/cpb.c110458
Yoshida, M., Haraguchi, T. and Uchida, T. (2014) Bitterness Evaluation of Acidic Pharmaceutical Substances (NSAIDs) Using a Taste Sensor. Chemical and Pharmaceutical Bulletin, 62, 1252-1258. https://doi.org/10.1248/cpb.c14-00577
Uchida, T., Yoshida, M., Hazekawa, M., Haraguchi, T., Furuno, H., Teraoka, M., et al. (2013) Evaluation of Palatability of 10 Commercial Amlodipine Orally Disintegrating Tablets by Gustatory Sensation Testing, OD-Mate as a New Disintegration Apparatus and the Artificial Taste Sensor. Journal of Pharmacy and Pharmacology, 65, 1312-1320. https://doi.org/10.1111/jphp.12101
Kobayashi, Y., Habara, M., Ikezazki, H., Chen, R., Naito, Y. and Toko, K. (2010) Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores. Sensors, 10, 3411-3443. https://doi.org/10.3390/s100403411
Haraguchi, T., Uchida, T., Yoshida, M., Kojima, H., Habara, M. and Ikezaki, H. (2018) The Utility of the Artificial Taste Sensor in Evaluating the Bitterness of Drugs: Correlation with Responses of Human TASTE2 Receptors (hTAS2Rs). Chemical and Pharmaceutical Bulletin, 66, 71-77. https://doi.org/10.1248/cpb.c17-00619
Ito, M., Yoshida, M., Kobayashi, Y., Hiraoka, M., Ikezaki, H. and Uchida, T. (2011) Bitterness Evaluation of H1-Receptor Antagonists Using a Taste Sensor. Sensors and Materials, 23, 483-492. https://doi.org/10.18494/SAM.2011.771
Haraguchi, T., Miyazaki, A., Yoshida, M. and Uchida, T. (2013) Bitterness Evaluation of Intact and Crushed Vesicare Orally Disintegrating Tablets Using Taste Sensors. Journal of Pharmacy and Pharmacology, 65, 980-987. https://doi.org/10.1111/jphp.12078
Haraguchi, T., Uchida, T., Hazekawa, M., Yoshida, M., Nakashima, M., Sanda, H., et al. (2016) Ability of Food/Drink to Reduce the Bitterness Intensity of Topiramate as Determined by Taste Sensor Analysis. Chemical and Pharmaceutical Bulletin, 64, 14-20. https://doi.org/10.1248/cpb.c15-00474
Hemdan, A. and Michael, A.M. (2018) Kinetic Profiling of the Hydrolytic Reaction of Benazepril: Metabolic Pathway Simulation. Journal of AOAC International, 101, 1009-1013. https://doi.org/10.5740/jaoacint.17-0121
Bhattacharya, S.S., Banerjee, S., Ghosh, A.K., Chattopadhyay, P., Verma, A. and Ghosh, A. (2013) A RP-HPLC Method for Quantification of Diclofenac Sodium Released from Biological Macromolecules. International Journal of Biological Macromolecules, 58, 354-359. https://doi.org/10.1016/j.ijbiomac.2013.03.065
Ali, I., Suhail, M., Alothman, Z.A. and Alwarthan, A. (2017) Chiral Separation and Modeling of Baclofen, Bupropion, and Etodolac Profens on Amylose Reversed Phase Chiral Column. Chirality, 29, 386-397. https://doi.org/10.1002/chir.22717
Yamagata, Y., Sakai, M. and Kayashita, J. (2012) Current Status and Issues of Modified Diet for Dysphagia Persons by Researching Physical Properties. The Japanese Journal of Dysphagia Rehabilitation, 16, 140-147.
Dehaene, S. (2003) The Neural Basis of the Weber-Fechner Law: A Logarithmic Mental Number Line. Trends in Cognitive Sciences, 7, 145-147. https://doi.org/10.1016/S1364-6613(03)00055-X
Yoshida, M., Kojima, H., Uda, A., Haraguchi, T., Ozeki, M., Kawasaki, I., et al. (2019) Bitterness-Masking Effects of Different Beverages on Zopiclone and Eszopiclone Tablets. Chemical and Pharmaceutical Bulletin, 67, 404-409. https://doi.org/10.1248/cpb.c18-00502
Lan, W., Zhu, H., Zhou, Z., Ye, C. and Liu, M. (2007) 1H-NMR Investigation on Interaction between Ibuprofen and Lipoproteins. Chemistry and Physics of Lipids, 148, 105-111. https://doi.org/10.1016/j.chemphyslip.2007.04.012.