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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP…
Noriyasu Seki, Hirotoshi Kataoka, Kunio Sugahara, Atsushi Fukunari, Kenji Chiba
Therapeutic administration of fingolimod hydrochloride (FTY720), the functional antagonist at sphingosine 1-phosphate (S1P) receptor 1 (S1P1) shows a marked improving effect on experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte…
Noriyasu Seki, Yasuhiro Maeda, Hirotoshi Kataoka, Kunio Sugahara, Kenji Chiba
Infiltration of myelin-specific helper T (Th) cells into the central nervous system (CNS) plays a key role in pathogenesis of experimental autoimmune encephalomyelitis (EAE). In this study, we investigated the involvement of sphingosine 1-phosphate (S1P)-S1P…
Jing Zeng, Feng Huang, Yuangqing Tu, Saichun Wu, Manping Li, Xiaoyun Tong
Protective effect of catalpol on myocardium was studied in relation to endothelial progenitor cells, Notch1 signaling pathway and angiogenesis in rats with isoprenaline (INN)-induced acute myocardial infarcts. To analyze the pathological status and impact of…
Mohammad Al-Kaseem, Zaid Al-Assaf, Franswa Karabet
A new methodology for extraction, pre-concentration and analysis of volatile nitrosamines in meat-derived products was developed and compared with conventional methods (Distillation and two-step solid-phase extraction). The samples (canned sausages, cured mea…
Pankaj K. Sahu, Deen Dayal Giri, Ritu Singh, Priyanka Pandey, Sharmistha Gupta, Atul Kumar Shrivastava, Ajay Kumar, Kapil Dev Pandey
The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine , and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural s…
Abdullah A. Alghasham
Melatonin (MEL) was investigated for protection against the anthracycline antibiotic doxorubicin (Dox) that is well known for its oxidative damage to various body organs. It was aimed to have a comparison of this protection to heart, liver and kidney in the t…
Jiangbei Cao, Wenzhu Shi, Weidong Mi, Hong Zhang
Background: The efficacy and safety of dexmedetomidine during the anesthesia induction of intracranial tumor patients remain unknown. We wondered whether loading infusion of dexmedetomidine 1 μ g/kg over 10 min to intracranial tumor patients was as efficient…
Hiroyuki Takabe, Moriyuki Ohkuma, Yasunori Iwao, Shuji Noguchi, Shigeru Itai
An initial burst is often observed during the release of active pharmaceutical ingredients (APIs) from poly-lactic-coglycolic-acid (PLGA) microparticles (MPs) which have been prepared by the emulsion-solvent evaporation method. Herein, we describe the develop…
Alicia Hernández Torres, Ana Belén Hernández Cascales, Pedro Pujante Alarcón, Alfonso López Ruiz, María Ángeles Ibáñez Gil, María Dolores Hellín Gil
Recent data suggest that, in addition to improving dyslipidemia, statin may reduce the risk of infections and infection-related complications. The aim of this study is to make a review of the literature about the effects of statins on clinically relevant outc…
Eman Said, Samar Farid, Nirmeen Sabry, May Fawzi
Background: Hyperglycemia in hospitalized patients is associated with poor clinical outcomes. Scheduled Subcutaneous Insulin therapy has been recommended for better glycemic control. Aims: To compare efficacy and safety of traditional sliding scale insulin (S…
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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
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