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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP…
Ram Achuthanandam, Dorie Makropoulos, Laura Johns, Amy Volk, Kerry Brosnan, Jin Lu, Wojciech Krzyzanski, Peter J. Bugelski
CNTO 530 and darbepoetin-a are long lived erythropoietin receptor agonists (ERAs). Clinically, anemia of chronic disease (ACD) is associated with increased expression of tumor necrosis factor-a (TNF-a) and mice transgenic for human TNF-a develop ACD. The purp…
Mitsue Ishisaka, Takashi Kudo, Masamitsu Shimazawa, Kenichi Kakefuda, Atsushi Oyagi, Kana Hyakkoku, Kazuhiro Tsuruma, Hideaki Hara
Depression is a significant public health concern but its pathology remains unclear. Previously, increases in an endoplasmic reticulum (ER) stress-related protein were reported in the temporal cortex of subjects with major depressive disorder who had died by…
Vanya B. Kurteva, Svilen P. Simeonov, Margarita Stoilova-Disheva
A series of 22 symmetrical acyclic aromatic aldazines were obtained and their qualitative antimicrobial activities were evaluated against 10 bacterial and 3 fungal species. The results demonstrated that the bi- and polycyclic aromatics studied are remarkably…
Olga G. Sitnikova, Sergey B. Nazarov, Irina V. Shikhanova, Alexander V. Agafonov, Jean A. Dyuzhev, rina G. Popova
In this study investigation of influence of hybrid nanosilica-polyethylene glycols materials (molecular weight 1500, 6000 and 15000), prepared by sol-gel synthesis, on lipid peroxidation and antioxidant activity of human serum in vitro was performed. Methods…
Minoru Kobayashi, Hisaya Sato
Structure analyses for hydrate models of ethyleneimine oligomer (5-mer as model of PEI) were investigated by quantum chemical calculations. Conformation energies and structures optimized for hydrate models of (ttt)5 and (tgt)5 conformers were examined. Hydrat…
Najah R. Hadi, Mohammad A. Abdelhussein, Omran M. O. Alhamami, Ammar R. Muhammad Rudha, Ekhlas Sabah
Evidence has long been existed regarding the relationship between oxidative stress and diabetes. The present study was conducted to assess the effect of atorvastatin on selected oxidative stress parameters and its effect on lipid profile parameters in dyslipi…
Denis Goue Gohore, Frédérique Fenneteau, Olivier Barrière, Jun Li, Fahima Nekka
Noncompliance to therapeutic regimen is a real public health problem with tremendous socioeconomic consequences. Instead of direct intervention to patients, which can add extra burden to the already overloaded health system, alternative strategies oriented to…
Chaker Ben Salem, Jaballah Sakhri, Neila Fathallah, Besma Trimech, Houssem Hmouda, Bouraoui Kamel
Objective: To report a case of drug interaction leading to rhabdomyolysis. Case Summary: A 65-year old woman suf-fering from chronic atrial fibrillation was treated with amiodarone and acenocoumarol. Two weeks after administration of conventional dosage of co…
Sandra de Cássia Dias, Fernanda Lucio dos Santos, Dirce Sakauchi, Dmitri Iourtov, Isaias Raw, Flavia Saldanha Kubrusly
This paper investigated the porcine surfactant protein A (pSP-A) immunogenicity in murine model. Many elegant stu-dies about SP-A therapeutic applications are available however specific studies about its exogenous immunogenicity were not easily assumed. There…
Tapan Kumar Giri, Biswanath Sa
This study was undertaken to develop tablets of diazepam-hydroxypropyl-β-cyclodextrin inclusion complex that disintegrate within 3 minutes and release 85% of drug within 30 minutes to provide rapid action of the drug through oro-mucosal route. Formation of in…
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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
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