The physical and psychological health challenges of Self-Medication (SM) for a pregnant woman and the unborn child spotlights it as an emergency. This unwraps a gap in epidemiological studies on SM and associated psychopathological symptoms among Nigerian pregnant women. This study examines the predictive influence of self-medication with Over The Counter (OTC) drugs on manifested psychopathological symptoms among pregnant women attending antenatal clinic in State Specialist Hospital, Osogbo, Osun State, southwestern Nigeria. Purposively selected 277 pregnant women ( age = 29.33; SD = 4.77) participated in the study. The participants responded to the Substance Abuse Prevalence Inventory, Self-Medication Test (SMT), and Awaritefe Psychological Index (API). Findings reveal a low prevalence of psychoactive drug use (2.8%) and a high prevalence of (OTC) drug self-medication (31.4%) and psychopathological symptoms (34.7%). Self-medication with OTC drugs independently and significantly predicted severities of insomnia (β = .178, p = .001), intellect disorder (β = .244, p = .000), heat disorder (β = .109, p = .046), mood disorder (β = .188, p = .001), head region disorder (β = .162, p = .003), alimentary tract disorder (β = .118, p = .030), general somatic disorder (β = .244, p = .000), and general psychopathology (β = .229, p = .000). The study reports a high prevalence of psychopathological symptoms among the Nigerian sample and concludes that the SM of OTC drugs is a significant predictor of the severity of the symptoms of psychopathology among pregnant women.
Abay, S. M., & Amelo, W. (2010). Assessment of Self-Medication Practices among Medical, Pharmacy, and Health Science Students in Gondar University, Ethiopia. Journal of Young Pharmacists, 2, 306-310. https://doi.org/10.4103/0975-1483.66798
Abduelmula, R., & Abduelkarem, H. M. (2017). Use of Over-the-Counter Medication among Pregnant Women in Sharjah, United Arab Emirates. Journal of Pregnancy, 2017, Article ID: 4503793. https://doi.org/10.1155/2017/4503793
Abula, T., & Worku, A. (2001). Self-Medication in Three Towns of North-West Ethiopia. The Ethiopian Journal of Health Development, 15, 25-30. https://doi.org/10.4314/ejhd.v15i1.9893
Afolabi, A. (2009). Factors Influencing the Pattern of Self-Medication in an Adult Nigerian Population. Annals of African Medicine, 7, 120-127. https://doi.org/10.4103/1596-3519.55666
Akinnawo, E., & Oforwe, C. (2012). A Validation Study of API-Form X on Nigerian Adolescents. IFE PsychologIA, 20, 41.
Al-Azri, M., Al-Lawati, I., Al-Kamyani, R. et al. (2016). Prevalence and Risk Factors of Antenatal Depression among Omani Women in a Primary Care Setting: Cross-Sectional Study. Sultan Qaboos University Medical Journal, 16, e35-e41. https://doi.org/10.18295/squmj.2016.16.01.007
Almasdy, D., & Sharrif, A. (2011). Self-Medication Practice with Nonprescription Medication among University Students: A Review of the Literature. Archives of Pharmacy Practice, 2, 95-100.
Alqahtani, A. H., Al Khedair, K., Al-Jeheiman, R. et al. (2018). Anxiety and Depression during Pregnancy in Women Attending Clinics in a University Hospital in Eastern Province of Saudi Arabia: Prevalence and Associated Factors. International Journal of Women’s Health, 10, 101-108. https://doi.org/10.2147/IJWH.S153273
Ameh, S., Adeleye, O. A., Kabiru, C. W. et al. (2016). Predictors of Poor Pregnancy Outcomes among Antenatal Care Attendees in Primary Health Care Facilities in Cross River State, Nigeria: A Multilevel Model. Maternal and Child Health Journal, 20, 1662-1672. https://doi.org/10.1007/s10995-016-1965-5
Amiel Castro, R. T., Pinard Anderman, C., Glover, V., O’Connor, T. G., Ehlert, U., & Kammerer, M. (2017). Associated Symptoms of Depression: Patterns of Change during Pregnancy. Archives of Women’s Mental Health, 20, 123-128. https://doi.org/10.1007/s00737-016-0685-6
Angamo, M. T., & Wabe, N. T. (2012). Knowledge, Attitude, and Practice of Self-Medication in Southwest Ethiopia. International Journal of Pharmaceutical Sciences and Research, 3, 1005-1010.
Atmadani, R. N., Nkoka, O., Yunita, S. L. et al. (2020). Self-Medication and Knowledge among Pregnant Women Attending Primary Healthcare Services in Malang, Indonesia: A Cross-Sectional Study. BMC Pregnancy Childbirth, 20, Article No. 42. https://doi.org/10.1186/s12884-020-2736-2
Avalew, M. B. (2017). Self-Medication Practice in Ethiopia: A Systematic Review. Patient Prefer Adherence, 11, 401-413. https://doi.org/10.2147/PPA.S131496
Awaritefe, A. (1982). The Awaritefe Psychological Index. Nigerian Journal of Clinical Psychology, 1, 45-51.
Ayanwale, M. B., Okafor, I. P., & Odukoya, O. O. (2017). Self-Medication among Rural Residents in Lagos, Nigeria. Journal of Tropical Medicine, 19, 65-71. https://doi.org/10.4103/jomt.jomt_51_16
Bennadi, D. (2014). Self-Medication: A Current Challenge. Journal of Basic and Clinical Pharmacy, 5, 19-23. https://doi.org/10.4103/0976-0105.128253
Brandlistuen, R. E., Ystrom, E., Nulman, I., Koren, G., & Nordeng, H. (2013). Prenatal Paracetamol Exposure and Child Neurodevelopment: A Sibling-Controlled Cohort Study. International Journal of Epidemiology, 42, 1702-1713. https://doi.org/10.1093/ije/dyt183
Buck, M. (2007). Self-Medication by Adolescents. Journal of Pediatric Pharmacy, 13, 1-4.
Center for Behavioral Health Statistics and Quality (2017). Results from the 2016 National Survey on Drug Use and Health: Detailed Tables. Rockville, MD: Substance Abuse and Mental Health Services Administration.
Centrum.ca (2016). Are You Getting Enough Iron? WebMD. http://www.webmd.com/baby/areyou-getting-enough-iron
Chang, F. R., & Trivedi, P. K. (2003). Economics of Self-Medication: Theory and Evidence. Health Economics, 12, 721 739. https://doi.org/10.1002/hec.841
Clevelandclinic (2016). Your Guide to a Healthy Pregnancy. Ob/Gyn & Women’s Health Institute. http://www.clevelandclinic.org/healthinfo/pdfv2/pdfs/15646.pdf
Czeizel, A. E., Gidai, J., Petik, D. et al. (2008). Self-Poisoning during Pregnancy as a Model for Teratogenic Risk Estimation of Drugs. Toxicology and Industrial Health, 24, 11-28. https://doi.org/10.1177/0748233708089020
Dellicour, S., ter Kuile, F. O., & Stergachis, A. (2008). Pregnancy Exposure Registries for Assessing Antimalarial Drug Safety in Pregnancy in Malaria-Endemic Countries. PLOS Medicine, 5, e187. https://doi.org/10.1371/journal.pmed.0050187
El Ezz, N. F., & Ez-Elarab, H. S. (2011). Knowledge, Attitude and Practice of Medical Students towards Self Medication at Ain Shams University, Egypt. Journal of Preventive Medicine and Hygiene, 52, 196-200.
Esan, D. T., Fasoro, A. A., Odesanya, O. E. et al. (2018). Assessment of Self-Medication Practices and its Associated Factors among Undergraduates of a Private University in Nigeria. Journal of Environmental and Public Health, 2018, Article ID: 5439079. https://doi.org/10.1155/2018/5439079
Eticha, T., & Mesfin, K. (2014). Self-Medication Practices in Mekelle, Ethiopia. PLoS ONE, 9, e97464. https://doi.org/10.1371/journal.pone.0097464
Fadare, J. O., & Tamuno, I. (2011). Antibiotic Self-Medication among University Medical Undergraduates in Northern Nigeria. Journal of Public Health and Epidemiology, 3, 217-220.
Fantel, A. G., Shepard, T. H., Newell-Morris, L. L. et al. (1977). Teratogenic Effects of Retinoic Acid in Pigtail Monkeys (Macaca Nemestrina) I. General Features. Teratology, 15, 65-71. https://doi.org/10.1002/tera.1420150109
Garofalo, L., Di Giuseppe, G., & Angelillo, I. F. (2015). Self-Medication Practices among Parents in Italy. BioMed Research International, 2015, Article ID: 580650. https://doi.org/10.1155/2015/580650
Gawlik, S., Waldeier, L., Müller, M. et al. (2013). Subclinical Depressive Symptoms during Pregnancy and Birth Outcome—A Pilot Study in a Healthy German Sample. Archives of Women’s Mental Health, 16, 93-100. https://doi.org/10.1007/s00737-012-0320-0
Gbagbo, F. Y., & Nkrumah, J. (2020). Implications of Self-Medication in Pregnancy for Safe Motherhood and Sustainable Development Goal-3 in Selected Ghanaian Communities. Public Health in Practice, 1, Article ID: 100017. https://doi.org/10.1016/j.puhip.2020.100017
Gebreegziabher, T. L., Berhe, D. F., Gutema, G. B., & Kabtyimer, B. N. (2012). Drug Utilization Pattern and Potential Teratogenesity Risk among Pregnant Women; the Case of Ayder Referral Hospital, Tigray Ethiopia. International Journal of Pharmaceutical Sciences and Research, 3, 137.
Goldstein, B. I., & Bukstein, O. G. (2010). Comorbid Substance Use Disorders among Youth with Bipolar Disorder: Opportunities for Early Identification and Prevention. Journal of Clinical Psychiatry, 71, 348-358. https://doi.org/10.4088/JCP.09r05222gry
Gutema, G. B., Gadisa, D. A., Kidanemariam, Z. A. et al. (2011). Self-Medication Practices among Health Sciences Students: The Case of Mekelle University. Journal of Applied Pharmaceutical Science, 1, 183-189.
Hanafy, A. S., Sallam, A. S., Kharboush, F. I. et al. (2016). Drug Utilization Pattern during Pregnancy in Alexandria, Egypt. European Journal of Pharmaceutical and Medical Research, 3, 19-29.
Howard, L. M., Molyneaux, E., Dennis, C. L., Rochat, T., Stein, A., & Milgrom, J. (2014). Non-Psychotic Mental Disorders in the Perinatal Period. The Lancet, 384, 1775-1788. https://doi.org/10.1016/S0140-6736(14)61276-9
Howard, L. M., Ryan, E. G., Trevillion, K., Anderson, F., Bick, D., Bye, A. et al. (2018). Accuracy of the Whooley Questions and the Edinburgh Postnatal Depression Scale in Identifying Depression and Other Mental Disorders in Early Pregnancy. The British Journal of Psychiatry, 212, 50-56. https://doi.org/10.1192/bjp.2017.9
Hughes, C. M., McElnay, J. C., & Fleming, G. F. (2001). Benefits and Risks of Self-Medication. Drug Safety, 24, 1027-1037. https://doi.org/10.2165/00002018-200124140-00002
Inamdar, I. F., Aswa, N. R., Snokar, V. K. et al. (2012). Drug Utilization Pattern during Pregnancy. Indian Medical Gazette, 146, 305-311.
Jalilian, F., Hazavehei, S. M., Vahidinia, A. A. et al. (2017). Prevalence and Related Factors for Choosing Self Medication among Pharmacies Visitors Based on Health Belief Model in Hamadan Province, West of Iran. Journal of Research in Health Sciences, 13, 81-85.
Jones, I., Chandra, P. S., Dazzan, P., & Howard, L. M. (2014). Bipolar Disorder, Affective Psychosis, and Schizophrenia in Pregnancy and the Post-Partum Period. The Lancet, 384, 1789-1799. https://doi.org/10.1016/S0140-6736(14)61278-2
Kamat, V. R., & Nichter, M. (1998). Pharmacies, Self-Medication and Pharmaceutical Marketing in Bombay, India. Social Science & Medicine, 47, 779-794. https://doi.org/10.1016/S0277-9536(98)00134-8
Karimy, M., Rezaee-Momtaz, M., Tavousi, M. et al. (2019). Risk Factors Associated with Self-Medication among Women in Iran. BMC Public Health, 19, 1033. https://doi.org/10.1186/s12889-019-7302-3
Karmaliani, R., Asad, N., Bann, C. M. et al. (2009). Prevalence of Anxiety, Depression, and Associated Factors among Pregnant Women of Hyderabad, Pakistan. International Journal of Social Psychiatry, 55, 414-424. https://doi.org/10.1177/0020764008094645
Khan, R. A. (2011). Self-Medication with Antibiotics: Practices among Pakistani Students in Sweden and Finland. Huddinge: Södertörns University.
Lacroix, I., Damase-Michel, C., Lapeyre-Mestre, M. et al. (2000). Prescription of Drugs during Pregnancy in France. The Lancet, 356, 1735-1736. https://doi.org/10.1016/S0140-6736(00)03209-8
Lawan, U. M., Abubakar, I. S., Jibo, A. M. et al. (2013). Pattern, Awareness and Perceptions of Health Hazards Associated with Self-Medication among Adult Residents of Kano Metropolis, North-Western Nigeria. Indian Journal of Community Medicine, 38, 144-151. https://doi.org/10.4103/0970-0218.116350
Leung, H. Y., Saini, B., & Ritchie, H. E. (2018). Medications and Pregnancy: The Role of Community Pharmacists—A Descriptive Study. PLoS ONE, 13, e0195101. https://doi.org/10.1371/journal.pone.0195101
Mihretie, T. M. (2014). Self-Medication Practices with Antibiotics among Urban Dwellers of Bahir Dar Town, North West Ethiopia. Addis Ababa: Addis Ababa University.
Minichino, A., Bersani, F. S., Calò, W. K. et al. (2013). Smoking Behaviour and Mental Health Disorders-Mutual Influences and Implications for Therapy. International Journal of Environmental Research and Public Health, 10, 4790-4811. https://doi.org/10.3390/ijerph10104790
Mitchell, A. A. (2002). Special Considerations in Studies of Drug-Induced Birth Defects. In B. L. Strom (Ed.), Pharmacoepidemiology (3rd ed., pp. 749-763). Chichester: John Wiley & Sons. https://doi.org/10.1002/0470842555.ch42
Mosley, J. F., Smith, L. L., & Dezan, M. D. (2015). An Overview of Upcoming Changes in Pregnancy and Lactation Labeling Information. Pharmacy Practice, 13, 605. https://doi.org/10.18549/PharmPract.2015.02.605
Mossa, D. A., Wabe, N. T., & Angamo, M. T. (2012). Self-Medication with Antibiotics and Antimalarials in the Community of Silte Zone, South Ethiopia. Türk Silahlı Kuvvetleri Koruyucu Hekimlik Bülteni, 11, 529-536. https://doi.org/10.5455/pmb.1-1314892446
Nasreen, H. E., Kabir, Z. N., Forsell, Y. et al. (2011). Prevalence and Associated Factors of Depressive and Anxiety Symptoms during Pregnancy: A Population-Based Study in Rural Bangladesh. BMC Womens Health, 11, 22. https://doi.org/10.1186/1472-6874-11-22
Olugbenga-Bello, A., Adebimpe, W., Osundina, F., & Abdulsalam (2013). Perception on Prevention of Mother to Child-Transmission (Pmtct) of HIV among Women of Reproductive Age Group in Osogbo, Southwestern Nigeria. https://doi.org/10.2147/IJWH.S45815
Omoluabi, P. F. (1995). A Review of the Incidence of Nonprescription Psychoactive Substance Use/Misuse in Nigeria. The International Journal of the Addictions, 30, 445-458. https://doi.org/10.3109/10826089509048736
Onisile, D. O., Akpunne, B. C., & Alakija, O. A. (2020). Psychoactive Substance and Psychopathological Symptoms among Nigerian Secondary Schools Adolescents. International Neuropsychiatric Disease Journal, 13, 1-10. https://doi.org/10.9734/indj/2019/v13i3-430114
Osemene, K. P., & Lamikanra, A. (2012). A Study of the Prevalence of Self-Medication Practice among University Students in South-Western Nigeria. Tropical Journal of Pharmaceutical Research, 11, 683-689. https://doi.org/10.4314/tjpr.v11i4.21
Peñacoba-Puente, C., Carmona-Monge, F. J., Marin-Morales, D. et al. (2013). Coping Strategies of Spanish Pregnant Women and Their Impact on Anxiety and Depression. Research in Nursing & Health, 36, 54-64. https://doi.org/10.1002/nur.21513
Ravindu, G., & Avinash, S. P. (2018). Drug Use during Pregnancy. MSD Manual, Consumer Version. https://www.msdmanuals.com/home/women-s-health-issues/drug-use-during-pregnancy/drug-use-during-pregnancy
Roser, M., & Ritchie, H. (2013). Maternal Mortality. https://ourworldindata.org/maternal-mortality
Ross, L., & McLean, M. (2006). Anxiety Disorders during Pregnancy and the Postpartum Period. A Systematic Review. The Journal of Clinical Psychiatry, 67, 1285-1298. https://doi.org/10.4088/JCP.v67n0818
Ruiz, M. E. (2007). Risks of Self-Medication Practices. Current Drug Safety, 5, 315-323. https://doi.org/10.2174/157488610792245966
Santucci, K. (2012). Psychiatric Disease and Drug Abuse. Current Opinion in Pediatrics, 24, 233-237. https://doi.org/10.1097/MOP.0b013e3283504fbf
Schwarz, U., Buschel, B., & Kirch, W. (2008). Unwanted Pregnancy on Self-Medication with St John’s Wort Despite Hormonal Contraception. British Journal of Clinical Pharmacology, 55, 112-113. https://doi.org/10.1046/j.1365-2125.2003.01716.x
Shankar, P., Partha, P., & Shenoy, N. (2002). Self-Medication and Non-Doctor Prescription Practices in Pokhara Valley, Western Nepal: A Questionnaire-Based Study. BMC Family Practice, 3, 17. https://doi.org/10.1186/1471-2296-3-17
Signal, T. L., Paine, S. J, Sweeney, B. et al. (2017). The Prevalence of Symptoms of Depression and Anxiety, and the Level of Life Stress and Worry in New Zealand Māori and Non-Māori Women in Late Pregnancy. Australian and New Zealand Journal of Psychiatry, 51, 168-176. https://doi.org/10.1177/0004867415622406
Sleath, B., Rubin, R. H., Campbell et al. (2001). Physician-Patient Communication about Over-the-Counter Medications. Social Science & Medicine, 53, 357-369. https://doi.org/10.1016/S0277-9536(00)00341-5
Suleman, S., Ketsela, A., & Mekonnen, Z. (2009). Assessment of Self-Medication Practices in Assendabo Town, Jimma Zone, South-Western Ethiopia. Research in Social and Administrative Pharmacy, 5, 76-81. https://doi.org/10.1016/j.sapharm.2008.04.002
Thiagayson, P., Krishnaswamy, G., Lim, M. L. et al. (2013). Depression and Anxiety in Singaporean High-Risk Pregnancies: Prevalence and Screening. General Hospital Psychiatry, 35, 112-116. https://doi.org/10.1016/j.genhosppsych.2012.11.006
Ward, S. A., Sevene, E. J., Hastings, I. M. et al. (2007). Antimalarial Drugs and Pregnancy: Safety, Pharmacokinetics, and Pharmacovigilance. The Lancet Infectious Diseases, 7, 136-144. https://doi.org/10.1016/S1473-3099(07)70025-7
Werler, M. M., Mitchell, A. A., Hernandez-Diaz, S., & Honein, M. A. (2005). Use of Over-the-Counter Medications during Pregnancy. American Journal of Obstetrics and Gynecology, 193, 771-777. https://doi.org/10.1016/j.ajog.2005.02.100
WHO World Health Organization (2013). WHO Guideline: Calcium Supplementation in Pregnant Women. http://apps.who.int/iris/bitstream/10665/85120/1/9789241505376_eng.pdf
WHO World Health Organization (2020). Safety of Medicines in Pregnancy: General Principles. https://www.who.int/reproductivehealth/publications/maternal_perinatal_health/clinical/en/
Wondesen, A., Satessa, G., & Gelaw, B. (2016). Drug Use Pattern among Pregnant Women in Adama Hospital Medical College, South East Shewa, Ethiopia. International Journal of Pharma Sciences, 6, 1426-1435.
Wood, A. J., Koren, G., Pastuszak, A. et al. (1998). Drugs in Pregnancy. The New England Journal of Medicine, 338, 1128-1137. https://doi.org/10.1056/NEJM199804163381607
World Health Organization (1998). The Role of the Pharmacist in Self-Care and Self-Medication: Report of the 4th WHO Consultative Group on the Role of the Pharmacist, The Hague, The Netherlands, 26-28 August 1998. World Health Organization. https://apps.who.int/iris/handle/10665/65860
Yang, T., Walker, M. C., Krewski, D., Yang, Q., Nimrod, C., Garner, P. et al. (2008). Maternal Characteristics Associated with Pregnancy Exposure to FDA Category C, D, and X Drugs in a Canadian Population. Pharmacoepidemiology and Drug Safety, 17, 270-277. https://doi.org/10.1002/pds.1538