The present paper comprehensively explores the multifaceted nature of mental health disorders, including their prevalence, societal impact (e.g., employment, social stigma), neurobiological underpinnings (e.g., brain chemistry, structure and function) and methods of diagnosis. In addition, the paper explores the cognitive costs associated with mental illness, specifically the decision-making deficits that often accompany mental health disorders. Finally, the paper discusses innovative approaches to mental health assessment, highlighting the potential of novel diagnostic tools to improve accuracy, efficiency, and accessibility.
KeywordsMental Health DisordersPrevalenceNeuroscienceDiagnosis
Abdou, A. M., Higashiguchi, S., Horie, K., Kim, M., Hatta, H., & Yokogoshi, H. (2006). Relaxation and Immunity Enhancement Effects of γ -Aminobutyric Acid (GABA) Administration in Humans. BioFactors , 26, 201-208. https://doi.org/10.1002/biof.5520260305
Adamu, M. J., Qiang, L., Nyatega, C. O., Younis, A., Kawuwa, H. B., Jabire, A. H., & Saminu, S. (2023). Unraveling the Pathophysiology of Schizophrenia: Insights from Structural Magnetic Resonance Imaging Studies. Frontiers in Psychiatry, 14, Article 1188603. https://doi.org/10.3389/fpsyt.2023.1188603
Ahn, J., & Lee, J. (2020). Machine Learning-Based Depression Detection Using Smartphone Data. IEEE Journal of Biomedical and Health Informatics, 24, 3726-3735.
Amaral, D. G., Schumann, C. A., Nordahl, C. W., & Courchesne, E. (2008). Brain Overgrowth in Autism: Evidence from Structural Magnetic Resonance Imaging. Journal of Autism and Developmental Disorders, 38, 321-337.
American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). APA.
Andrews, P. W., Bharwani, A., Lee, K. R., Fox, M., & Thomson, J. A. (2015). Is Serotonin an Upper or a Downer? The Evolution of the Serotonergic System and Its Role in Depression and the Antidepressant Response. Neuroscience & Biobehavioral Reviews, 51, 164-188. https://doi.org/10.1016/j.neubiorev.2015.01.018
Bandelow, B., Baldwin, D., Abelli, M., Bolea-Alamanac, B., Bourin, M., Chamberlain, S. R. et al. (2016). Biological Markers for Anxiety Disorders, OCD and PTSD: A Consensus Statement. Part II: Neurochemistry, Neurophysiology and Neurocognition. The World Journal of Biological Psychiatry, 18, 162-214. https://doi.org/10.1080/15622975.2016.1190867
Barlow, D. H. (2002). Anxiety and Its Disorders: A Clinical Guide to Assessment and Treatment. Guilford Publications.
Baron-Cohen, S., Wheelwright, S., & Hill, J. (2000). The Amygdala Theory of Autism. Neuroreport , 11, 3837-3840.
Basile, C., Iannone, V., & Ricciardi, D. (2019). Facial Expression Analysis for Automatic Detection of Depression: A Review. Journal of Affective Disorders, 253, 1-10.
Beaumont, J. G., & Fleming, C. (2014). The Use of Mobile Health Interventions for the Delivery of Cognitive-Behavioral Therapy: A Systematic Review. Journal of Medical Internet Research, 16, e153.
Beck, A. T. (1979). Cognitive Therapy and Emotional Disorders. Guilford Publications.
Beck, A. T., Rush, A. J., Shaw, B. F., & Emery, G. (1979). Cognitive Therapy of Depression. Guilford Publications.
Berk, M., Dodd, S., Kauer-Sant’Anna, M., Malhi, G. S., Bourin, M., Kapczinski, F. et al. (2007). Dopamine Dysregulation Syndrome: Implications for a Dopamine Hypothesis of Bipolar Disorder. Acta Psychiatrica Scandinavica, 116, 41-49. https://doi.org/10.1111/j.1600-0447.2007.01058.x
Bressan, R. A., & Crippa, J. A. (2005). The Role of Dopamine in Reward and Pleasure Behaviour—Review of Data from Preclinical Research. Acta Psychiatrica Scandinavica, 111, 14-21. https://doi.org/10.1111/j.1600-0447.2005.00540.x
Buchsbaum, M. S., Haier, R. J., Potkin, S. G., Nuechterlein, K., Bracha, H. S., Katz, M. et al. (1992). Frontostriatal Disorder of Cerebral Metabolism in Never-Medicated Schizophrenics. Archives of General Psychiatry, 49, 935-942. https://doi.org/10.1001/archpsyc.1992.01820120023005
Bureau of Justice Statistics (2017). Indicators of Mental Health Problems Reported by Prisoners and Jail Inmates, 2011-12. https://bjs.ojp.gov/content/pub/pdf/imhprpji1112.pdf
Carpenter, W. T., Strauss, J. P., & Bartko, J. J. (1974). Part III. Speculations on the Processes That Underlie Schizophrenic Symptoms and Signs. Schizophrenia Bulletin, 1, 61-69. https://doi.org/10.1093/schbul/1.11.61
Chen, H., Long, J., Yang, S., & He, B. (2021). Atypical Functional Covariance Connectivity between Gray and White Matter in Children with Autism Spectrum Disorder. Autism Research, 14, 464-472. https://doi.org/10.1002/aur.2435
Choudhury, P. R., Lahiri, S., & Rajamma, U. (2012). Glutamate Mediated Signaling in the Pathophysiology of Autism Spectrum Disorders. Pharmacology Biochemistry and Behavior, 100, 841-849. https://doi.org/10.1016/j.pbb.2011.06.023
Dichter, G. S., & Weiner, M. (2011). Functional Brain Connectivity in Autism Spectrum Disorders: A Review. Journal of Neurodevelopmental Disorders, 3, 113-129.
Druss, B. G., Zhao, L., Von Esenwein, S., Morrato, E. H., & Marcus, S. C. (2011). Understanding Excess Mortality in Persons with Mental Illness: 17-Year Follow up of a Nationally Representative US Survey. Medical Care, 49, 599-604. https://doi.org/10.1097/mlr.0b013e31820bf86e
Eisenmann, A., & Origanti, F. (2021). Homeless Rights: A Call for Change. Journal of Social Distress and Homelessness, 30, 90-96. https://doi.org/10.1080/10530789.2019.1705519
Enneking, V., Leehr, E. J., Dannlowski, U., & Redlich, R. (2020). Brain Structural Effects of Treatments for Depression and Biomarkers of Response: A Systematic Review of Neuroimaging Studies. Psychological Medicine, 50, 187-209. https://doi.org/10.1017/s0033291719003660
Fazel, S., Långström, N., Hjern, A., Grann, M., & Lichtenstein, P. (2009). Schizophrenia, Substance Abuse, and Violent Crime. JAMA, 301, 2016-2023. https://doi.org/10.1001/jama.2009.675
Fox, N. C., Scahill, R. G., Rossor, M. N., & Roberts, G. W. (1996). Ventricular Enlargement in Alzheimer’s Disease: A Quantitative MRI Study. Neurology, 47, 273-281.
Gaiha, S. M., Taylor Salisbury, T., Koschorke, M., Raman, U., & Petticrew, M. (2020). Stigma Associated with Mental Health Problems among Young People in India: A Systematic Review of Magnitude, Manifestations and Recommendations. BMC Psychiatry, 20, Article No. 538. https://doi.org/10.1186/s12888-020-02937-x
Garcia-Arocena, D. (2015). Happy or SAD: The Chemistry Behind Depression. https://www.jax.org/news-and-insights/jax-blog/2015/december/happy-or-sad-the-chemistry-behind-depression#
Ghiasi, N., Azhar, Y., & Singh, J. (2023). Psychiatric Illness and Criminality. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK537064/
Goldstein, R. B., & Fillmore, M. T. (2008). Addiction and Decision-Making. Academic Press.
Goodman, L. A., Salyers, M. P., Mueser, K. T., Rosenberg, S. D., Swartz, M., Essock, S. M. et al. (2001). Recent Victimization in Women and Men with Severe Mental Illness: Prevalence and Correlates. Journal of Traumatic Stress, 14, 615-632. https://doi.org/10.1023/a:1013026318450
Goodwin, F. K., & Jamison, K. R. (1990). Manic-Depressive Illness: A Comprehensive Guide to Bipolar Disorder. Oxford University Press.
Goodwin, F. K., & Jamison, K. R. (2007). Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression (Vol. 2). Oxford University Press.
Greenwald, A. G., McGhee, D. E., Schwartz, M. K., & Banaji, M. R. (1998). Measuring Implicit Social Cognition and Attitudes. Journal of Personality and Social Psychology, 74, 1001-1014.
Hiday, V. A., Swanson, J. W., Swartz, M. S., Borum, R., & Wagner, H. R. (2001). Victimization: A Link between Mental Illness and Violence? International Journal of Law and Psychiatry, 24, 559-572. https://doi.org/10.1016/s0160-2527(01)00091-7
Ingvar, D., & Franzén, G. (1974). Distribution of Cerebral Activity in Chronic Schizophrenia. The Lancet, 304, 1484-1486. https://doi.org/10.1016/s0140-6736(74)90221-9
Jack, C. R., Petersen, R. C., Ojemann, S. G., Toga, A. W.， & Fennell, T. J. (1997). Progressive Atrophy of the Hippocampal Formation and Cerebral Cortex in Alzheimer’s Disease. Annals of Neurology, 42, 731-738.
Kang, S., Cho, S., Na, K., Lee, J. S., Joo, S. W., Cho, S. et al. (2020). Differences in Brain Surface Area and Cortical Volume between Suicide Attempters and Non-Attempters with Major Depressive Disorder. Psychiatry Research: Neuroimaging, 297, Article ID: 111032. https://doi.org/10.1016/j.pscychresns.2020.111032
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophrenia Bulletin, 13, 261-276. https://doi.org/10.1093/schbul/13.2.261
Lawrie, S. M., & Abukmeil, S. S. (1998). Brain Abnormality in Schizophrenia: A Systematic and Quantitative Review of Volumetric Magnetic Resonance Imaging Studies. British Journal of Psychiatry, 172, 110-120. https://doi.org/10.1192/bjp.172.2.110
Lim, J., Kim, S., Seo, S., Kang, W., Kim, A., Kang, Y. et al. (2021). Association of Prefrontal Cortex Thinning with High Impulsivity in Healthy Adults. Psychiatry Investigation, 18, 570-579. https://doi.org/10.30773/pi.2020.0404
Loonen, A. J. M., & Ivanova, S. A. (2016). Circuits Regulating Pleasure and Happiness—Mechanisms of Depression. Frontiers in Human Neuroscience, 10, Article 571. https://doi.org/10.3389/fnhum.2016.00571
Madaan, S., & Gupta, S. (2020). Machine Learning for Mental Health Assessment: A Systematic Review. Journal of Medical Systems, 44, 1-12.
Mayo Clinic (2024). Pet Scan of the Brain for Depression. https://www.mayoclinic.org/tests-procedures/pet-scan/multimedia/-pet-scan-of-the-brain-for-depression/img-20007400
Mossman, S. A., Luft, M. J., Schroeder, H. K., Varney, S. T., Fleck, D. E., Barzman, D. H., Strawn, J. R. et al. (2017). The Generalized Anxiety Disorder 7-Item (GAD-7) Scale in Adolescents with Generalized Anxiety Disorder: Signal Detection and Validation. Annals of Clinical Psychiatry, 29, 227-234A.
Muir, J. L. (1997). Acetylcholine, Aging, and Alzheimer's Disease. Pharmacology Biochemistry and Behavior, 56, 687-696. https://doi.org/10.1016/s0091-3057(96)00431-5
National Alliance on Mental Illness (2017a). Continuing Disparities in Access to Mental and Physical Health. https://www.nami.org/wp-content/uploads/2023/08/DoctorIsOut.pdf
National Alliance on Mental Illness (2017b). Can Stigma Prevent Employment? https://www.nami.org/advocate/can-stigma-prevent-employment/#:~:text=Individuals%20living%20with%20the%20condition,disabilities%20in%20the%20United%20States
National Institute of Mental Health (2024). Mental Illness. https://www.nimh.nih.gov/health/statistics/mental-illness
Nock, M. K., & Banaji, M. R. (2009). Implicit Self-Esteem in Depression: A Meta-Analytic Review. Journal of Abnormal Psychology, 118, 221-227.
Pizzagalli, D. A., & Roberts, A. C. (2022). Prefrontal Cortex and Depression. Neuropsychopharmacology, 47, 225-246. https://doi.org/10.1038/s41386-021-01101-7
Porges, S. W. (2011). Polyvagal Theory: Neurophysiological Foundations of Emotions, Attachment, and Communication. Handbook of Clinical Neuropsychology, 3, 787-813.
Pourhamzeh, M., Moravej, F. G., Arabi, M., Shahriari, E., Mehrabi, S., Ward, R. et al. (2022). The Roles of Serotonin in Neuropsychiatric Disorders. Cellular and Molecular Neurobiology, 42, 1671-1692. https://doi.org/10.1007/s10571-021-01064-9
Puglisi-Allegra, S., & Andolina, D. (2015). Serotonin and Stress Coping. Behavioural Brain Research, 277, 58-67. https://doi.org/10.1016/j.bbr.2014.07.052
Rao, Y. L., Ganaraja, B., Murlimanju, B. V., Joy, T., Krishnamurthy, A., & Agrawal, A. (2022). Hippocampus and Its Involvement in Alzheimer’s Disease: A Review. 3 Biotech, 12, Article No. 55. https://doi.org/10.1007/s13205-022-03123-4
Rathbone, A. L., Clarry, L., & Prescott, J. (2017). Assessing the Efficacy of Mobile Health Apps Using the Basic Principles of Cognitive Behavioral Therapy: Systematic Review. Journal of Medical Internet Research, 19, e399. https://doi.org/10.2196/jmir.8598
Reinert, M., Fritze, D., & Nguyen, T. (2024). The State of Mental Health in America 2024. Mental Health America. https://mhanational.org/sites/default/files/2024-State-of-Mental-Health-in-America-Report.pdf
Reznick, J. S., Baranek, G. T., Reavis, S., Watson, L. R., & Crais, E. R. (2007). A Parent-Report Instrument for Identifying One-Year-Olds at Risk for an Eventual Diagnosis of Autism: The First Year Inventory. Journal of Autism and Developmental Disorders, 37, 1691-1710. https://doi.org/10.1007/s10803-006-0303-y
Schmaal, L., Hibar, D. P., Sämann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N. et al. (2017). Cortical Abnormalities in Adults and Adolescents with Major Depression Based on Brain Scans from 20 Cohorts Worldwide in the ENIGMA Major Depressive Disorder Working Group. Molecular Psychiatry, 22, 900-909. https://doi.org/10.1038/mp.2016.60
Schroeder, R., & Thayer, J. F. (2002). The Effects of Relaxation Techniques on Heart Rate Variability in Healthy Individuals. Health Psychology, 21, 358-364.
Staal, W. G., Hulshoff Pol, H. E., Schnack, H. G., Hoogendoorn, M. L. C., Jellema, K., & Kahn, R. (2000). Structural Brain Abnormalities in Patients with Schizophrenia and Their Healthy Siblings. American Journal of Psychiatry, 157, 416-421. https://doi.org/10.1176/appi.ajp.157.3.416
Swanson, J. W., Holzer, C. E., Ganju, V. K., & Jono, R. T. (1990). Violence and Psychiatric Disorder in the Community: Evidence from the Epidemiologic Catchment Area Surveys. Psychiatric Services, 41, 761-770. https://doi.org/10.1176/ps.41.7.761
Thayer, J. F., Ahs, F., Fredrikson, M., & Sollers, J. J. (2012). Heart Rate Variability, Autonomic Nervous System Function, and the Psychophysiology of Emotion Regulation. European Journal of Social Psychology, 42, 73-84.
Towbin, K. E. (2005). Pervasive Developmental Disorder Not Otherwise Specified. In F. R. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of Autism and Pervasive Developmental Disorders: Diagnosis, Development, Neurobiology, and Behavior (3rd ed., pp. 165-200). John Wiley & Sons, Inc.
Treatment Advocacy Center (2015). Overlooked in the Undercounted: The Role of Mental Illness in Fatal Law Enforcement Encounters. https://www.tac.org/reports_publications/overlooked-in-the-undercounted-the-role-of-mental-illness-in-fatal-law-enforcement-encounters/
Vacchiano, M. (2023). How the First COVID-19 Lockdown Worsened Younger Generations’ Mental Health: Insights from Network Theory. Sociological Research Online, 28, 884-893. https://doi.org/10.1177/13607804221084723
Viron, M. J., & Stern, T. A. (2010). The Impact of Serious Mental Illness on Health and Healthcare. Psychosomatics, 51, 458-465. https://doi.org/10.1016/s0033-3182(10)70737-4
Volkow, N. D., Fowler, J. S., & Wang, G. J. (2003). Brain Reward Mechanisms and Addiction to Nicotine and Other Psychostimulants. Nature, 421, 315-321.
Wegrzyn, D., Juckel, G., & Faissner, A. (2022). Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models. International Journal of Molecular Sciences, 23, Article 5482. https://doi.org/10.3390/ijms23105482
Weinstein, J. J., Chohan, M. O., Slifstein, M., Kegeles, L. S., Moore, H., & Abi-Dargham, A. (2017). Pathway-specific Dopamine Abnormalities in Schizophrenia. Biological Psychiatry, 81, 31-42. https://doi.org/10.1016/j.biopsych.2016.03.2104
Whalen, P. J. (2007). The Uncertainty of It All. Trends in Cognitive Sciences, 11, 499-500. https://doi.org/10.1016/j.tics.2007.08.016
Yeh, H., Westphal, J., Hu, Y., Peterson, E. L., Williams, L. K., Prabhakar, D. et al. (2019). Diagnosed Mental Health Conditions and Risk of Suicide Mortality. Psychiatric Services, 70, 750-757. https://doi.org/10.1176/appi.ps.201800346
Yu, Z., Liu, X., Wang, Z., & Zhang, J. (2020). A Machine Learning Approach for Early Detection of Depression Based on Smartphone Data. Journal of Medical Systems, 44, 142.
Zheng, R., Zhang, Y., Yang, Z., Han, S., & Cheng, J. (2021). Reduced Brain Gray Matter Volume in Patients with First-Episode Major Depressive Disorder: A Quantitative Meta-analysis. Frontiers in Psychiatry, 12, Article 671348. https://doi.org/10.3389/fpsyt.2021.671348