Adolescence is a transitional stage from childhood to adulthood, marked by cerebral maturation accompanied by a neurodevelopmental upheaval. It is a critical biological stage of high vulnerability for the consumption of psychoactive substances (PAS), but also a phase of identity research influenced by the level of self-esteem. The objective of this study is to explore the prevalence of consumption of the PAS and the links with the levels of self-esteem among adolescents attending school in Kenitra. Moreover, the study is transversal, including 714 young students (high school students) aged 15 to 21 years. The instrument used is an anonymous self-questionnaire centered on the uses, attitudes and opinions relating to psychoactive substances, self-questionnaire for adolescents: Rosenberg’s Self-esteem Scale. Our result shows also a deficit of self-esteem in both adolescent populations. However, it is more expressed among consumers (t = -7.191, p < 0.001). Thus, 57.99% of consumers have low self-esteem and 26.04% have very low self-esteem. While among the non-consumer population, 50.28% have low self-esteem and 9.72% have very low self-esteem.
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