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Children’s Genomic Instability in Association with Balance of the Autonomous Nerve System Departments
Laboratory of Genetic Toxicology of Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Moscow, Russia
Municipal Educational Institution, “Secondary School No. 5 with Advanced Study of Mathematics” of the Magnitogorsk. Magnitogorsk, Russia
Laboratory of Genetic Toxicology of Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Moscow, Russia
Laboratory of Genetic Toxicology of Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Moscow, Russia
Laboratory of Genetic Toxicology of Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Moscow, Russia
Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Laboratory of Genetic Toxicology, Moscow, Russia
Department of Epidemiology and Evidence-Based Medicine of I.M.Sechenov First Moscow State Medical University, Mos-cow, Russia
- 1 Laboratory of Genetic Toxicology of Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Moscow, Russia
- 2 Municipal Educational Institution, “Secondary School No. 5 with Advanced Study of Mathematics” of the Magnitogorsk. Magnitogorsk, Russia
- 3 Laboratory of Genetic Toxicology of Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Moscow, Russia
- 4 Laboratory of Genetic Toxicology of Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Moscow, Russia
- 5 Laboratory of Genetic Toxicology of Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Moscow, Russia
- 6 Federal State Budgetary Institution, “Center for Strategic Planning and Management of Medical and Biological Health Risks”, Russian Ministry of Health, Laboratory of Genetic Toxicology, Moscow, Russia
- 7 Department of Epidemiology and Evidence-Based Medicine of I.M.Sechenov First Moscow State Medical University, Mos-cow, Russia
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Abstract
This article presents new results of the investigation of anxiety and balance of the departments of autonomic nervous system of 178 healthy 5 - 7 years old children living in 2 different districts of Magnitogorsk town. It is shown that the state of increased and high anxiety more often was detected among children living around the Magnitogorsk Iron and Steel Combine (MISC). Among these children, an imbalanced work of the departments of autonomic nervous system (mostly ergotropic tone) found out more often than among children, living in the other district of the town. The increased genome instability as well as individual sensitivity of children’s genome to standard genotoxic load determined in vitro in peripheral blood cultures (micronucleus test with Cytochalasin B) correlated with children’s psychosomatic characteristics, especially for those who lived around the MISC.
KeywordsChildren of 5 - 7 YearsAnxietyBalance of the Departments of Autonomous Nervous SystemGenomic InstabilityMicronuclei Test with Cytochalasin B
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