Excess Weight Loss after Bariatric Surgery: The Influence of Catechol-O-Methyltransferase (COMT) Polymorphism (Val108/158Met), Sociodemographic Variables and Physical Activity — Oak Academic Publishing
Research ArticleOpen AccessGoogle Scholar indexed
Excess Weight Loss after Bariatric Surgery: The Influence of Catechol-O-Methyltransferase (COMT) Polymorphism (Val108/158Met), Sociodemographic Variables and Physical Activity
Department of Psychology, University of Innsbruck, Innsbruck, Austria
,
Department of Psychology, University of Innsbruck, Innsbruck, Austria
,
Department of Psychology, University of Innsbruck, Innsbruck, Austria
,
Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria
1 Department of Psychology, University of Innsbruck, Innsbruck, Austria
2 Department of Psychology, University of Innsbruck, Innsbruck, Austria
3 Department of Psychology, University of Innsbruck, Innsbruck, Austria
4 Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria
Background: In the treatment of morbid obesity bariatric surgery has become the method of choice. Dopamine is the primary modulator of the brain’s reward system and plays an essential role in the regulation of food intake. The role of dopamine is well documented in weight regulation and food intake in both animal models and humans. Still, the role of dopamine has not been well studied for weight loss. Catechol-O-methyltransferase (COMT) degrades catecholamines and estrogens are both known to be important risk factors for cardiovascular diseases and consequently obesity. The gene coding for COMT contains a Val108/158Met polymorphism that exerts a considerable influence on enzymatic activity. We hypothesized that this polymorphism might influence weight loss in obese patients, who previously underwent gastric banding surgery. In obesity research, it is known that women tend to lose more weight than men, and weight before surgery might also affect the outcome of weight loss efforts. Several studies have shown that physical activity (PA) plays an important role in maintaining weight as well as in both non-surgical and surgical weight loss. Therefore, we examined whether gender, age, weight before surgery and PA are good predictor variables for the outcome of surgical weight loss. Methods: One to six years after bariatric surgery 74 adults underwent a semi-structured interview. In a second step data on the post-surgical PA level were collected with the Moorehead-Ardelt Quality of Life Questionnaire. Finally, mouth swabs were used for genotyping. Results: 54 women and 20 men were enrolled between January 2004 and September 2009. Short-term EWL in the mid-activity genotype dopamine group (GA) was significantly higher (p = 0.007) than was short-term EWL in the low-activity genotype dopamine group (AA) or in the high-activity genotype dopamine group (GG). However, there were no significant differences between the COMT groups with respect to long-term EWL. Long-term we determined that EWL is significantly positively influenced by PA and negatively by gender. The effect of EWL was more pronounced in female than in male subjects. Conclusion: Various individual genotypes of the COMT polymorphism (Val108/158Met) make an impact only on short-term EWL, but not on long-term EWL. However, gender and PA proved to be good surgical weight loss predictors for long-term EWL.
KeywordsCOMT Polymorphism (Val108/158Met)Bariatric SurgeryExcess Weight Loss (EWL)Physical Activity (PA)
O’Brien, P.E. (2010) Bariatric Surgery: Mechanisms, Indications and Outcomes. Journal of Gastroenterology and Hepatology, 8, 1358-1365. https://doi.org/10.1111/j.1440-1746.2010.06391.x
Razquin, C., Martin, A. and Martinez, J.A. (2001) Evidences on Three Relevant Obesogenes. Molecular Nutrition & Food Research, 55, 136-149. https://doi.org/10.1002/mnfr.201000445
Fawcett, K.A. and Barroso, I. (2010) The Genetics of Obesity: FTO Leads the Way. Trends in Genetics, 26, 266-274. https://doi.org/10.1016/j.tig.2010.02.006
Kinzl, J.F. (2010) Morbid Obesity: Significance of Psychological Treatment after Bariatric Surgery. Eating and Weight Disorders, 15, e275-e280.
Creveling, C.R. (2003) The Role of Catechol-O-Methyltransferase in the Inactivation of Catecholestrogen. Cellular and Molecular Neurobiology, 23, 289-291. https://doi.org/10.1023/A:1023680302975
Halford, J.C.G., Cooper, G.D. and Dovey, T.M. (2004) The Pharmacology of Human Appetite Expression. Current Drug Targets, 5, 221-240. https://doi.org/10.2174/1389450043490541
Wallace, D.L., Aarts, E., d’Oleire Uquillas, F., Dang, L.C., Greer, S.M., Jagust, W.J. and D’Esposito, M. (2015) Genotype Status of the Dopamine-Related Catechol-O-Methyltransferase (COMT) Gene Corresponds with Desirability of “Unhealthy” Foods. Appetite, 92, 74-80. https://doi.org/10.1016/j.appet.2015.05.004
Nedic, G., Nikolac, M., Nenadic Sviglin, K., Muck-Seler, D., Borovecki, F. and Pivac, N. (2001) Association Study of Functional Catechol-O-Methyltransferase (COMT) Val108/158 Met Polymorphism and Suicide Attempts in Patients with Alcohol Dependence. International Journal of Neuropsychopharmacology, 14, 377-388. https://doi.org/10.1017/S1461145710001057
Nedic, G., Borovecki, F., Klepac, N., Mubrin, Z., Hajnsek, S., Nikolac, M., Muck-Seler, D. and Pivac, N. (2011) Association Study of a Functional Catechol-O-Methyltransferase Polymorphism and Cognitive Function in Patients with Dementia. Collegium Antropologicum, 35, 79-84.
Malhotra, A.K., Lencz, T., Correll, C.U. and Kane, J.M. (2007) Genomics and the Future of Pharmacotherapy in Psychiatry. International Review of Psychiatry, 19, 523-530. https://doi.org/10.1080/09540260701563460
Nedic Erjavec, G., Nenadic Sviglin, K., Nikolac Perkovic, M., Muck-Seler, D., Jovanovic, T. and Pivac, N. (2014) Association of Gene Polymorphisms Encoding Dopaminergic System Components and Platelet MAO-B Activity with Alcohol Dependence and Alcohol Dependence-Related Phenotypes. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 54, 321-327. https://doi.org/10.1016/j.pnpbp.2014.07.002
Lachman, H.M., Papolos, D.F., Saito, T., Yu, Y.M., Szumlanski, C.L. and Weinshilboum, R.M. (1996) Human Catechol-O-Methyltransferase Pharmacogenetics: Description of a Functional Polymorphism and Its Potential Application to Neuropsychiatric Disorders. Pharmacogenetics, 6, 243-250. https://doi.org/10.1097/00008571-199606000-00007
Lotta, T., Vidgren, J., Tilgmann, C., Ulmanen, I., Melen, K., Julkunen, I. and Taskinen, J. (1995) Kinetics of Human Soluble and Membrane-Bound Catechol-O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme. Biochemistry, 34, 4202-4210. https://doi.org/10.1021/bi00013a008
Chen, J., Lipska, B.K., Halim, N., Ma, Q.D., Matsumoto, M., Melhem, S., et al. (2004) Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Humain Brain. The American Journal of Human Genetics, 75, 807-821. https://doi.org/10.1086/425589
González-Castro, T.B., Hernández-Díaz, Juráez-Rojop, I.E., Lòpez-Narváez, M.L., Tovilla-Zárate, C.A. and Fresan, A. (2016) The Role of Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-Analysis on 32,816 Subjects. NeuroMolecular Medicine, 18, 216-231. https://doi.org/10.1007/s12017-016-8392-z
Avsar, O., Kuskucu, A., Sancak, S. and Genc, E. (2017) Are Dopaminergic Genotypes Risk Factors for Eating Behavior and Obesity in Adults? Neuroscience Letters, 654, 28-32. https://doi.org/10.1016/j.neulet.2017.06.023
Annerbrink, K., Westberg, L., Nilsson, S., Rosmond, R., Holm, G. and Eriksson, E. (2008) Catechol-O-Methyltransferase val158-Met Polymorphism Is Associated with Abdominal Obesity and Blood Pressure in Men. Metabolism—Clinical and Experimental, 57, 708-711. https://doi.org/10.1016/j.metabol.2008.01.012
Kamide, K., Kokubo, Y., Yang, J., Matayoshi, T., Inamoto, N., Takiuchi, S., et al. (2007) Association of Genetic Polymorphisms of ACADSB and COMT with Human Hypertension. Journal of Hypertension, 25, 103-110. https://doi.org/10.1097/HJH.0b013e3280103a40
Kochkodan, J., Telem, D.A. and Ghaferi, A.A. (2018) Physiologic and Psychological Gender Differences in Bariatric Surgery. Surgical Endoscopy, 32, 1382-1388. https://doi.org/10.1007/s00464-017-5819-z
Kautzky-Willer, A. (2016) Brennpunkt Adipositas: What Gender Has to Do with...! Wiener Medizinische Wochenschrift, 166, 75-78. https://doi.org/10.1007/s10354-016-0440-7
Rippe, J.M. and Hess, S. (1998) The Role of Physical Activity in the Prevention and Management of Obesity. Journal of the Academy of Nutrition and Dietetics, 98, S31-S38. https://doi.org/10.1016/S0002-8223(98)00708-1
Jacobi, D., Ciangura, C., Couet, C. and Oppert, J.M. (2011) Physical Activity and Weight Loss Following Bariatric Surgery. Obesity Reviews, 12, 366-377. https://doi.org/10.1111/j.1467-789X.2010.00731.x
Dag, D.D. (2014) Interdisziplinäre Leitlinie der Qualität S3 zur “Prävention und Therapie der Adipositas”. Deutsche Adipositas Gesellschaft, Deutsche Gesellschaft für Ernährung, Deutsche Gesellschaft für Ernährungsmedizin, Version 2.0.
Moorehead, M.K., Ardelt-Gattinger, E., Lechner, H., et al. (2003) The Validation of the Moorehead-Ardelt Quality of Life Questionnaire II. Obesity Surgery, 5, 684-692. https://doi.org/10.1381/096089203322509237
Deitel, M.E. and Greenstein, R.J. (2003) Recommendations for Reporting Weight Loss. Obesity Surgery, 13, 159-160. https://doi.org/10.1381/096089203764467117
Hong, C.C., Thompson, H.J., Jiang, C., Hammond, G.L., Trichler, D., Yaffe, M., et al. (2003) Val158Met Polymorphism in Catechol-O-Methyltransferase Gene Associated with Risk Factors for Breast Cancer. Cancer Epidemiology, Biomarkers & Prevention, 12, 838-847.
Happonen, P., Voutilainen, S., Tuomainen, T.P. and Salonen, J.T. (2006) Catechol-O-Methyltransferase Gene Polymorphism Modifies the Effect of Coffee Intake on Incidence of Acute Coronary Events. PLoS ONE, 1, e117. https://doi.org/10.1371/journal.pone.0000117
Voutilainen, S., Tuomainen, T.P., Korhonen, M., Mursu, J., Virtanen, J.K., Happonen, P., et al. (2007) Functional COMT Val158Met Polymorphism, Risk of Acute Coronary Events and Serum Homocysteine: The Kuopio Ischaemic Heart Disease Risk Factor Study. PLoS ONE, 2, e181. https://doi.org/10.1371/journal.pone.0000181
Metcalf, B., Rabkin, R.A., Rabkin, J.M., Metcalf, L. and Lehman-Becker, L.B. (2005) Weight Loss Composition: The Effects of Exercise Following Obesity Surgery as Measured by Bioelectrical Impedance Analysis. Obesity Surgery, 15, 183-186. https://doi.org/10.1381/0960892053268381
Bond, D.S., Phelan, S., Leahey, T.M., Hill, J.O. and Wing, R.R. (2009) Weight-Loss Maintenance in Successful Weight Losers: Surgical vs Non-Surgical Methods. International Journal of Obesity, 33, 173-180. https://doi.org/10.1038/ijo.2008.256
Price, P.H., Kaizer, A.M., Daniels, S.R., Jenkins, T.M., Inge, T.H. and Eckel, R.H. (2019) Physical Activity Improves Lipid and Weight-Loss Outcomes After Metabolic Bariatric Surgery in Adolescents with Severe Obesity. Obesity, 27, 989-996. https://doi.org/10.1002/oby.22475
Herman, K.M., Carver, T.E., Christou, N.V. and Andersen, R.E. (2014) Physical Activity and Sitting Time in Bariatric Surgery Patients 1 - 16 Years Post-Surgery. Clinical Obesity, 4, 267-276. https://doi.org/10.1111/cob.12069