Unexpected Metastatic Recurrent Myxofibrosarcoma: A Scenario That May Be More Common than You Think
- 1 Facultad de Medicina, Universidad Autónoma de Yucatán (UADY), Mérida, México
- 2 Department of General Surgery, Clínica Hospital Mérida ISSSTE, Mérida, México
- 3 Facultad de Medicina, Universidad Autónoma de Yucatán (UADY), Mérida, México
- 4 Facultad de Medicina, Universidad Autónoma de Yucatán (UADY), Mérida, México
- 5 Department of Radiology, Clínica Hospital Mérida ISSSTE, Mérida, México
Abstract
Soft tissue sarcomas represent only 1% of all adult cancers; myxofibrosarco ma is the most common type that arises in adult extremities, particularly lower limbs (77%), other less common locations are the trunk (12%) and neck (3%). Usually presenting as a painless, subcutaneous, slow growing mass with tendenc y for recurrence, they are prone to have higher histological grade an d metastatic potential after recurrence; even in optimal multidisciplinary setti ngs patients can have incomplete resections, making metastatic dise ase more co mmon after misdiagnosis. We present the case of a 69-year-old male patient with a right infraescapular tumor, presenting as a painless 15 × 8 cm, mobile mass, with a slow but progressive growth, history of a previous tumor excised at the same location 5 years prior without histopathological report.
- Pankova, V., Thway, K., Jones, R.L. and Huang, P.H. (2021) The Extracellular Matrix in Soft Tissue Sarcomas: Pathobiology and Cellular Signalling. Frontiers in Cell and Developmental Biology, 9, Article ID: 763640. https://doi.org/10.3389/fcell.2021.763640
- D’Angelo, L.A., Arora, Y. and Carrillo, R.G. (2022) Acute Presentation of a High-Grade Myxofibrosarcoma Originating in the Thoracic Wall: A Case Report. Chest, 161, e1-e4. https://doi.org/10.1016/j.chest.2021.07.2179
- Ghazala, C.G., Agni, N.R., Ragbir, M., Dildey, P., Lee, D., Rankin, K.S., Beckingsale, T.B. and Gerrand, C.H. (2016) Myxofibrosarcoma of the Extremity and Trunk: A Multidisciplinary Approach Leads to Good Local Rates of LOCAL Control. The Bone & Joint Journal, 98-B, 1682-1688. https://doi.org/10.1302/0301-620X.98B12.37568
- Roland, C.L., Wang, W.L., Lazar, A.J. and Torres, K.E. (2016) Myxofibrosarcoma. Sugical Oncology Clinics of North America, 25, 775-788.
- Teurneau, H., Engellau, J., Ghanei, I., Vult von Steyern, F. and Styring, E. (2019) High Recurrence Rate of Myxofibrosarcoma: The Effect of Radiotherapy Is Not Clear. Sarcoma, 2019, Article ID: 8517371. https://doi.org/10.1155/2019/8517371
- Boughzala-Bennadji, R., Stoeckle, E., Le Péchoux, C., Méeus, P., Honoré, C., Attal, J., Duffaud, F., et al. (2018) Localized Myxofibrosarcomas: Roles of Surgical Margins and Adjuvant Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics, 102, 399-406. https://doi.org/10.1016/j.ijrobp.2018.05.055
- van der Horst, C.A.J., Bongers, S.L.M., Versleijen-Jonkers, Y.M.H., Ho, V.K.Y., Braam, P.M., Flucke, U.E., et al. (2022) Overall Survival of Patients with Myxofibrosarcomas: An Epidemiological Study. Cancers, 14, 1102. https://doi.org/10.3390/cancers14051102
- Morag, Y. and Lucas, D. (2021). Ultrasound of Myxofibrosarcoma. Skeletal Radiology, 51, 1-10. https://doi.org/10.1007/s00256-021-03869-7
- Laforga, J.B. and Camarasa, N. (2016) High-Grade Myxofibrosarcoma Studied by Fine-Needle Aspiration: A Case Report. Revista Española de Patología, 49, 181-185. https://doi.org/10.1016/j.patol.2015.10.006
- Spinnato, P. and Clinca, R. (2021) MRI Tail Sign in Soft-Tissue Sarcoma. Radiology, 299, 276. https://doi.org/10.1148/radiol.2021203877
- Vanni, S., De Vita, A., Gurrieri, L., Fausti, V., Miserocchi, G., Spadazzi, C., et al. (2022) Myxofibrosarcoma Landscape: Diagnostic Pitfalls, Clinical Management and Future Perspectives. Therapeutic Advances in Medical Oncology, 14. https://doi.org/10.1177/17588359221093973