Efficacy of Vagus Nerve Stimulation (VNS) after Multiple Subpial Transections (MST) for Extra-Temporal Seizure Foci

Abstract

Background: The effect of Vagus nerve stimulation (VNS) therapy following major resective surgeries has been re ported. However, the effect of VNS therapy following multiple-subpial-transections (MST) has not been reported. The objective of this paper is to examine the beneficial effect of VNS therapy following MST. Methods: There are 22 pa tients aged 10 - 55 years. Male/female distribution is 11/11 and follow-up is 24 - 148 months (median of 120 months). Seizure foci were bilateral in 9 patients, multi-lobar (unilateral) in 12 patients and single-lobar in 1 patient. MST was performed over broad areas in and around the seizure foci. VNS implantation was done when the response to MST pro cedure was poor (1 patients), or there was recurrence of seizures (21 patients). Interval between MST and VNS implant tation varied from one month to three years (median of 2 years). Results: Thirteen patients (59%) are seizure free (Engel’ Class I), 8 (36.5%) have greater than 90% reduction in seizure frequency (Class II), and 1 (4.5%) has between 50% - 90% reduction in seizure frequency (C lass III). Conclusion: The results show that VNS therapy produced meaningful improvement in seizure outcome in all patients with extra-temporal seizures that ha d inadequate re sponse to MST.