Effect of Post-ERCP Pancreatitis on Perioperative Factors of Pancreaticoduodenectomy

Abstract

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly performed for biliary drainage and examination of the biliary and pancreatic duct before pancreaticoduodenectomy (PD). The influence of preoperative post-ERCP pancreatitis on PD is unknown. The aim of this study was to evaluate the relation between post-ERCP pancreatitis before PD and surgical outcomes of PD. Methods: We examined 38 patients who underwent PD. The relations between post-ERCP pancreatitis before PD and perioperative factors of PD such as patient characteristics, operative findings, and postoperative course were evaluated with univariate and multivariate analyses. Results: Post-ERCP pancreatitis was observed in 12 (37.5%) of the 38 patients. Univariate analyses showed operative procedure ( P = 0.034), operation time ( P = 0.004), blood loss ( P = 0.031), C-reactive protein ( P = 0.043), and delayed gastric emptying ( P = 0.035) to be significantly associated with post-ERCP pancreatitis. Multivariate analyses showed operation time (OR, 1.017; 95%CI, 1.000 - 1.034; P = 0.049) and delayed gastric emptying (OR, 18.72; 95%CI, 1.139 - 307.6; P = 0.040) to be significantly associated with post-ERCP pancreatitis. Conclusions: Post-ERCP pancreatitis was associated with prolonged operation time and delayed gastric emptying in patients undergoing PD.