The surgical Treatment and Outcome of Pathological Fracture in Patients with Giant Cell Tumor of Bone
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Abstract
Between 1992 and 2008, we treated 35 patients with giant cell tumor (GCT) of bone, seven of the 35 pre-sented with a pathological fracture. The fractures were located in the femur in five, and in the humerus and radius in one patient each. The surgical treatments were curettage in six cases and wide resection in the distal radius case. Two of the seven patients developed local recurrence, giving a local recurrence rate of 29%. The local recurrence rate in GCT patients without a pathological fracture was 21%. There was a tendency for there to be a higher recurrence rate associated with fractured GCT, but no statistically significant difference was observed between the two groups. Therefore, it was considered that a pathological fracture was not a risk factor for local recurrence in GCT.
- J. A. Bramer, A. A. Abudu, R. J. Grimer, S. R. Carter, and R. M. Tillman, “Do Pathological Fractures Influence Survival and Local Recurrence Rate in Bony Sarcomas?” European Journal of Cancer, Vol. 43, No. 13, September 2007, pp. 1944-1951. doi:10.1016/j.ejca.2007.07.004
- S. P. Scully, H. T. Temple, R. J. O’Keefe, H. J. Mankin and M. Gebhardt, “The Surgical Treatment of Patients with Osteosarcoma Who Sustain a Pathologic Fracture,” Clinical Orthopaedics and Related Research, No. 324, March 1996, pp. 227-32. doi:10.1097/00003086-199603000-00028
- H. R. Blackley, J. S. Wunder, A. M. Davis, L. M. White, R. Kandel and R. S. Bell, “Treatment of Giant-Cell Tu-mors of Long Bones with Curettage and Bone-Grafting,” Journal of Bone and Joint Surgery American Volume, Vol. 81, No. 6, June 1999, pp. 811-820.
- D. C. Dahlin, R. E. Cupps and E. W. Johnson Jr., “Giant-Cell Tumor: A Study of 195 Cases,” Cancer, Vol. 25, No. 5, May 1970, pp. 1061-1070. doi:10.1002/1097-0142(197005)25:5 3.0.CO;2-E
- F. M. Klenke, D. E. Wenger, C. Y. Inwards, P. S. Rose and F. H. Sim, “Recurrent Giant Cell Tumor of Long Bones: Analysis of Surgical Management,” Clinical Or-thopaedics and Related Research, No. 469, April 2011, pp. 1181-1187. doi:10.1007/s11999-010-1560-9
- F. Vult von Steyern, H. C. Bauer, C. Trovik, A. Kivioja, P. Bergh, P. Holmberg J?rgensen, G. Foller?s and A. Rydholm, “Treatment of Local Recurrences of Giant Cell Tumour in Long Bones after Curettage and Cementing. A Scandinavian Sarcoma Group Study,” Journal of Bone and Joint Surgery British Volume, Vol. 88, No. 4, April 2006, pp. 531-535. doi:10.1302/0301-620X.88B4.17407
- P. J. McGrath, “Giant-Cell Tumour of Bone: An Analysis of Fifty-Two Cases,” Journal of Bone and Joint Surgery British Volume, Vol. 54, No. 2, May 1972, pp. 216-229.
- S. E. Larsson, R. Lorentzon and L. Boquist, “Giant-Cell Tumor of Bone. A Demographic, Clinical, and Histopa-thological Study of All Cases Recorded in the Swedish Cancer Registry for the Years 1958 through 1968,” Journal of Bone and Joint Surgery American Volume, Vol. 57, No. 2, March 1975, pp. 167-73.
- M. Campanacci, N. Baldini, S. Boriani and A. Sudanese, “Giant-Cell Tumor of Bone,” Journal of Bone and Joint Surgery American Volume, Vol. 69, No. 1, January 1987, pp. 106-114.
- F. M. Klenke, D. E. Wenger, C. Y. Inwards, P. S. Rose and F. H. Sim, “Giant Cell Tumor of bone: Risk Factors for Recurrence,” Clinical Orthopaedics and Related Re-search, Vol. 469, No. 2, February 2011, pp. 591-599. doi:10.1007/s11999-010-1501-7