Role of Platelet Rich Plasma in Treatment of Diabetic Foot Ulcers
- 1 Faculty of Medicine, Zagazig University, Zagazig, Egypt
- 2 Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Objectives: The aim of this study is to compare between the platelet rich plasma and balanced moist dressing as regards the healing rate in chronic non ischemic diabetic foot ulcers. Patients and Method: From Feb. 2014 till May 2015, 73 patients from the attendees to Zagazig university hospitals were selected to our study. 2 groups were created, one for PRP (platelet rich plasma) and the other for balanced moist dressing. Frequent registration for the number of healed ulcers was done every week. Results: By the end of the 3 rd week almost all the ulcers in the PRP group were healed. But the other group needed about 8 th weeks for the same results. Conclusion: PRP seems to be an attractive choice in management of chronic diabetic ulcers provided that there is good blood supply and proper offloading was done.
- Alvarsson, A., Sandgren, B., Wendel, C., Alvarsson, M. and Brismar, K. (2012) A Retrospective Analysis of Amputation Rates in Diabetic Patients: Can Lower Extremity Amputations Be Further Prevented? Cardiovascular Diabetology, 11, 18. http://dx.doi.org/10.1186/1475-2840-11-18
- Armstrong, G.D. and Lavery, A.L. (1998) Diabetic Foot Ulcers, Prevention, Diagnosis and Classification. American Family Physician, 57, 1325-1332.
- Cervelli, V., Gentile, P., Scioli, M.G., Grimaldi, M., Casciani, C.U., et al. (2009) Application of Platelet-Rich Plasma in Plastic Surgery: Clinical and in Vitro Evaluation. Tissue Engineering Part C, Methods, 15, 625-663. http://dx.doi.org/10.1089/ten.tec.2008.0518
- Kim, D.H., Kim, C.D., Lee, Y.H., Seo, Y.J., Lee, J.H. and Lee, Y. (2011) Can Platelet-Rich Plasma Be Used for Skin Healing? Evaluation of Effects of Platelet-Rich Plasma on Human Dermal Fibroblast. Annals of Dermatology, 23, 424-431. http://dx.doi.org/10.5021/ad.2011.23.4.424
- Steed, D.L. (1995) Clinical Evaluation of Recombinant Human Platelet-Derived Growth Factor for the Treatment of Lower Extremity Diabetic Ulcers: The Diabetic Ulcer Study Group. Journal of Vascular Surgery, 21, 71-78. http://dx.doi.org/10.1016/S0741-5214(95)70245-8
- Cruciani, M., Lipsky, B.A., Mengoli, C. and de Lalla, F. (2013) Granulocyte-Colony Stimulating Factors as Adjunctive Therapy for Diabetic Foot Infections. The Cochrane Database of Systematic Reviews, 8, CD006810. http://dx.doi.org/10.1002/14651858.cd006810.pub3
- Saad Setta, H., Elshahat, A., Elsherbiny, K., Massoud, K. and Safe, I. (2011) Platelet-Rich Plasma versus Platelet-Poor Plasma in the Management of Chronic Diabetic Foot Ulcers: A Comparative Study. International Wound Journal, 8, 307-312. http://dx.doi.org/10.1111/j.1742-481X.2011.00797.x
- Lon, A.M., Zaroo, M.I., Laway, B.A., Pala, N.A., Bashir, S.A. and Rasool, A. (2014) PRP versus Conventional Dressings in the Management of Diabetic Foot Ulcers: A Prospective Case-Control Study. Diabetic Foot & Ankle, 54, 671-678.
- McAleer, J.P., Sharma, S., Kaplan, E.M. and Persich, G. (2006) Use of Autologous Platelet Concentrates in a Nonhealing Lower Extremity Wound. Advances in Skin & Wound Care, 19, 354-363. http://dx.doi.org/10.1097/00129334-200609000-00010
- Margolis, D.J., Kantor, J. and Santanna, J. (2001) Effectiveness of Platelet Releasate for the Treatment of Diabetic Neuropathic Foot Ulcers. Diabetes Care, 24, 483-488. http://dx.doi.org/10.2337/diacare.24.3.483