Research ArticleOpen AccessGoogle Scholar indexed
Spindle Cell Carcinoma of the Maxilla: A Case Report of Rare Entity
Department of Otorhinolaryngology-Head and Neck Surgery, Jinnah Medical and Dental College, Karachi, Pakistan
Department of Otorhinolaryngology-Head and Neck Surgery, Royal Manchestor Infirmary, Manchester, UK
Department of Otorhinolaryngology-Head and Neck Surgery, Sir Syed College of Medical Sciences, Karachi, Pakistan
- 1 Department of Otorhinolaryngology-Head and Neck Surgery, Jinnah Medical and Dental College, Karachi, Pakistan
- 2 Department of Otorhinolaryngology-Head and Neck Surgery, Royal Manchestor Infirmary, Manchester, UK
- 3 Department of Otorhinolaryngology-Head and Neck Surgery, Sir Syed College of Medical Sciences, Karachi, Pakistan
Copy link · social · email
Abstract
Spindle cell carcinoma also known as sarcomatoid carcinoma is a rare highly aggressive tumor which is histologically different from squamous cell ca and mesenchymal cancers. Only hands full of cases have been reported in literature since 1957 and hence no proper treatment protocol has been devised yet. We present such a case of thirty-four-year-old female who presented with spindle cell carcinoma of the maxilla at our department and was treated with extensive surgery followed by chemotherapy and radiation therapy. Spindle cell carcinoma is generally associated with poor prognosis and hence literature supports use of post operative Chemo and Radiotherapy for better result and decrease chance of local recurrence.
KeywordsSpindle Cell CarcinomaMaxillaMaxillary Carcinoma
- Roy, S., Purgina, B. and Seethala, R. (2013) Spindle Cell Carcinoma of the Larynx with Rhabdomyoblastic Heterologous Element: A Rare Form of Divergent Differentiation. Head and Neck Pathology, 7, 263-267. https://doi.org/10.1007/s12105-012-0402-3
- Su, H.H., Chu, S.T., Hou, Y.Y., Cjang, K.P. and Chen, C.J. (2006) Spindle Cell Carcinoma of the Oral Cavity and Oropharynx: Factors Affecting Outcome. Journal of the Chinese Medical Association, 69, 478-483. https://doi.org/10.1016/S1726-4901(09)70312-0
- Prakash, N., Kumar, H., Sharada, P. and Pradeep, G. (2010) Spindle Cell Carcinoma of the Oral Cavity: A Case Report of a Rare Entity and Review of Literature. World Journal of Dentistry, 1, 55-58. https://doi.org/10.5005/jp-journals-10015-1011
- Leventon, G.S. and Evans, H.L. (1981) Sarcomatoid Squamous Cell Carcinoma of the Mucous Membranes of the Head and Neck: A Clinicopathologic Study of 20 Cases. Cancer, 48, 994-1003. https://doi.org/10.1002/1097-0142(19810815)48:4 3.0.CO;2-M
- Takata, T., Ito, H., Ogawa, I., Miyauchi, M., Ijuhin, N. and Nikai, H. (1991) Spindle Cell Squamous Carcinoma of the Oral Region. An Immunohistochemical and Ultrastructural Study on the Histogenesis and Differential Diagnosis with a Clinic-Pathological Analysis of Six Cases. Virchows Archiv A, 419, 177-182. https://doi.org/10.1007/BF01626345
- Viswanathan, S., Rahman, K., Pallavi, S., et al. (2010) Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre. Head and Neck Pathology, 4, 265-275. https://doi.org/10.1007/s12105-010-0204-4
- Alem, H. and AlNoury, M. (2014) Management of Spindle Cell Carcinoma of the Maxillary Sinus: A Case Report and Literature Review. American Journal of Case Reports, 15, 454-458. https://doi.org/10.12659/AJCR.891007
- Jordan, R.C.K. and Regezi, J. (2003) A Oral spindle Cell Neoplasm: A Review of 307 Cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 95, 717-724. https://doi.org/10.1067/moe.2003.1400
- Miyajima, Y., Onizawa, K., Kamma, H., et al. (2006) Carcinosarcoma of the Tongue. Oral Oncology Extra, 42, 78-81. https://doi.org/10.1016/j.ooe.2005.09.004
- Kim, E.J., Che, Z.M., Park, Y.J., et al. (2009) Morphogenesis and Biological Significance of Spindle Cell Transformation in a Spindle Cell Carcinoma. Cancer Letters, 275, 61-71. https://doi.org/10.1016/j.canlet.2008.10.004