Contribution of Cytology for the Diagnosis of Gallbladder Carcinoma to Avoid Misdiagnosis in This Commonly Resected Organ
- 1 Department of General and Oncologic Surgery, Bejaia Teaching Hospital, Bejaia, Algeria
- 2 Faculty of Medicine, University of Bejaia, Bejaia, Algeria
- 3 Department of General Surgery, Ain Taya Hospital, Algiers, Algeria
- 4 Faculty of Medicine, University of Algiers, Algiers, Algeria
Abstract
The cytological study of gallbladder bile is a diagnostic tool used very often in the treatment of gallbladder cancer. The diagnosis of gall bladder cancer is done by morphological examinations such as ultrasound, computed tomography in 80% of cases, but in some difficult cases, benign lesions associated with malignant lesions, such as pseudo-tumoral cholecystitis, adenomyosis or adenoma and cancers requiring medical treatment by chemotherapy or radiotherapy, is without the possibility of surgical treatment. Cytology can help resolve a number of difficult situations, such as the presence of an intra-gallbladder lesion in the form of a polyp or nodule. Some studies have reported very interesting results from gallbladder cytology to cancer diagnosis with results up to 85% sensitivity. The purpose of this study is to analyze the contribution of the cytological study of gallbladder bile to the positive diagnosis of gallbladder cancer.
- Higuchi, R., Ota, T., Araida,T., Kajiyama, H., Yazawa, T., Furukawa, T., Yoshikawa, T., Takasaki, K. and Yamamoto, M. (2014) Surgical Approaches to Advanced Gallbladder Cancer. A 40-Year Single-Institution Study of Prognostic Factors and Resectability. Annals of Surgical Oncology, 21, 4308-4316. https://doi.org/10.1245/s10434-014-3885-1
- Ben-Josef, E., Guthrie, K.A., El-Khoueiry, A.B., Corless, C.L., Zalupski, M.M., Lowy, A.M., Thomas Jr., C.R, Alberts, S.R., Dawson, L.A., Micetich, K.C., Thomas, M.B., Siegel, A.B. and Blanke, C.D. (2014) SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma. Journal of Clinical Oncology, 33, 2617-2622. https://doi.org/10.1200/JCO.2014.60.2219
- Lendoire, J.C., Gil, L., Duek, F., Quarin, C., Garay, V., Raffin, G., Rivaldi, M., Alejandra, O. and Imventarza, O. (2012) Relevance of Residual Disease after Liver Resection for Incidental Gallbladder Cancer. HPB, 14, 548-553. https://doi.org/10.1111/j.1477-2574.2012.00498.x
- Alonso de Ruiz, P., Albores-Saavedra, J., Henson, D.E. and Monroy, M.N. (1982) Cytopathology of Precursor Lesions of Invasive Carcinoma of the Gallbladder: A Study of Bile Aspirated from Surgically Excised Gallbladder. Acta Cytologica, 26, 144-152.
- Ishikawa, O., Ohhigashi, H., Sasaki, Y., Imaoka, S., Iwanaga, T., Wada, A., Ishiguro, S., Tateishi, R., Kishigami, Y. and Sone, H. (1988) The Usefulness of Saline-Irrigated Bile Intraoperative for the Cytologic Diagnosis of Tumors and Tumorlike Lesions of the Gallbladder. Acta Cytologica, 32, 475-481.
- Akosa, A.B., Barker, F., Desa, L., Benjamin, I. and Krausz, T. (1995) Cytologic Diagnosis in the Management of Gallbladder Carcinoma. Acta Cytologica, 39, 494-498.
- Hale, M.D., Roberts, K.J., Hodson, J., Scott, N., Sheridan, M. and Toogood, G.J. (2014) Xanthogranulomatous Cholecystitis: A European and Global Perspective. HPB, 16, 448-458. https://doi.org/10.1111/hpb.12152
- Gupta, P. and Gupta, R.K. (2012) Preoperative Diagnosis of Squamous Cell Carcinoma of the Gallbladder by Ultrasound-Guided Aspiration Cytology: Clinical and Cytological Findings of Nine Cases. Journal of Gastrointestinal Cancer, 43, 638-641. https://doi.org/10.1007/s12029-012-9413-2
- Jo, Y.G., Lee, T.H., Cho, H.D., Park, S.H., Park, J.M., Cho, Y.S., Jung, Y., Chung, I.K., Choi, H.J., Moon, J.H., Cha, S.W., Cho, Y.D. and Kim, S.J. (2014) Diagnostic Accuracy of Brush Cytology with Direct Smear and Cell-Block Techniques According to Preparation Order and Tumor Characteristics in Biliary Strictures. The Korean Journal of Gastroenterology, 63, 223-230. https://doi.org/10.4166/kjg.2014.63.4.223