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Evaluation of Antioxidant and Anti-Inflammatory Effect of <i>Rhododendron brachycarpum</i> Extract Used in Skin Care Product by <i>in Vitro</i> and <i>in Vivo</i> Test
R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
- 1 R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
- 2 R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
- 3 R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
- 4 R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
- 5 R&D Center, Natural Solution Co., Ltd., Incheon, South Korea
Technology and Investment·Volume 06 (2015)·Pages 105–111·Published 11 March 2015·DOI10.4236/ti.2015.62011
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Abstract
In this study, we aimed to observe the cytotoxicity, antioxidant and anti-inflammatory activity of Rhododendron brachycarpum extract (RbE) in RAW 264.7 macrophage cell in vitro and the anti-inflammatory or soothing effect of RbE formulated cream (Multicalm-RHTM) on experimentally induced acute irritated skin in healthy subjects in vivo. In vitro study revealed that RbE significantly inhibited NO and ROS generation in a dose dependent manner without cytotoxicity. In clinical test, Multicalm-RHTM cream siginificantly reduced the SLS-enduced erythema after D5 compared to that of placebo. Overall, it can be concluded that the RbE is a non-cytotoxic, antioxidant and anti-irritant agent which can be used as a potent functional ingredient in cosmetics. Likewise, the in vivo clinical study shows that Multicalm-RHTM cream which contains 3% RbE can be used as an effective skin soothing agent.
KeywordsAntioxidantAnti-InflammatoryCytotoxic<i>Rhododendron brachycarpum</i>Cosmetics
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