This study examines long run economic cost of HIV/AIDS on agriculture. Twenty-two African Countries were identi fied through purposive sampling. The sampling procedure helped to identif y 1420 affected households. However, 1300 observations were found suitable for the subsequent analysis. Data were subjected to descriptive statistic s and Overlapping Generation (OLG) model. The causes of high prevalence rates are the issue of poverty, fertility, myth and migration among others. Factors responsible for the classification of high HIV/AIDS prevalence rates were the patterns of spread of infectious disease that are closely associated with patterns of human mobility. For lower HIV/AIDS preva lence rate factors were low values of procreation and high values placed on morals. A positive correlation between HIV prevalence and GDP per capita was found. The study found out that there is a curvilinear relationship between the course of the HIV/AIDS epidemic and agricultural/economic growth in terms of human capita development.
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