Clinical Trial of <i>Medicinal Synthetic Aluminum-Magnesium Silicate</i> (Antivirt<sup>®</sup>) on Viral Loads and CD4-Lymphocytes Counts of HIV/AIDS Patients
- 1 College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria
- 2 Basic Health Clinic, Abuja, Nigeria
- 3 College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria
- 4 College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria
Abstract
For clinical trial of Medicinal synthetic Aluminum-magnesium silicate (MSAMS, Antivirt<sup> ®</sup> ), on viral loads and CD4-lymphocytes counts of HIV/AIDS patients, 10 volunteers were treated. Their blood samples were tested for viral loads and for CD4-lymphocytes counts, before the treatment and every 4 weeks during the medication. The regimen was: MSAMS (50 mg/kg), MSAMS-stabilized Ampicillin trihydrate (7.5 mg/kg) and immunace extra protection <sup> ®</sup> (1 tablet/day), for 4 weeks. Then, it was reduced to 50 mg/kg (MSAMS) and the immune stimulant. When their viral loads become undetectable, they would be treated for additional 4 weeks. Initially, the Antivirt <sup> ®</sup> -regimen appeared to worsen both HIV infection-load and immune deficiency but later relieved them. Patients’ mean-viral load increased (P = 0.020), from 1820.30 ± 868.75 to 2855.90 ± 960.98, after 4 weeks before reducing (P = 0.030) to 1565.20 ± 743.17, after 8 weeks. Similarly, their mean-CD4-lymphocytes count reduced (P = 0.008) from 496.80 ± 194.39 to 263.90 ± 149.26, after 4 weeks before improving (P = 0.001) to 507.90 ± 133.19, after 8 weeks.
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