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Nanoscale Stiffness Distribution in Bone Metastasis
Centre National de la Recherche Scientifique (CNRS), UMR, Faculté de Pharmacie de l’Université de Strasbourg (UdS), Illkirch, France
Institut National de la Santé et de la Recherche Médicale (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR, Faculté de Médecine de l’Université de Strasbourg and FMTS, Strasbourg, France
Faculté de Chirurgie Dentaire de l’Université de Strasbourg (UdS), Strasbourg, France
Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Institut National de la Santé et de la Recherche Médicale (INSERM), UMR, Faculté de Médecine Laënnec de l’Université Claude Bernard Lyon 1, Lyon, France
Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- 1 Centre National de la Recherche Scientifique (CNRS), UMR, Faculté de Pharmacie de l’Université de Strasbourg (UdS), Illkirch, France
- 2 Institut National de la Santé et de la Recherche Médicale (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR, Faculté de Médecine de l’Université de Strasbourg and FMTS, Strasbourg, France
- 3 Faculté de Chirurgie Dentaire de l’Université de Strasbourg (UdS), Strasbourg, France
- 4 Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- 5 Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- 6 Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- 7 Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- 8 Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- 9 Institut National de la Santé et de la Recherche Médicale (INSERM), UMR, Faculté de Médecine Laënnec de l’Université Claude Bernard Lyon 1, Lyon, France
- 10 Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- 11 Hôpitaux Universitaires de Strasbourg, Strasbourg, France
World Journal of Nano Science and Engineering·Volume 05 (2015)·Pages 219–228·Published 13 November 2015·DOI10.4236/wjnse.2015.54023
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Abstract
Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.
KeywordsBone MetastasisStiffnessRisedronate
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