Low-Dose Gamma Radiation Fields Decrease Cell Viability, Damage DNA, and Increase the Expression of Hsp70 and p53 Proteins in Human Leukocytes — Oak Academic Publishing
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Low-Dose Gamma Radiation Fields Decrease Cell Viability, Damage DNA, and Increase the Expression of Hsp70 and p53 Proteins in Human Leukocytes
Laboratorio de Biología Celular y Neurobiología, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, México
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Laboratorio de Biología Celular y Neurobiología, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, México
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Laboratorio de Radiobiología, Unidad Académica de Estudios Nucleares, Universidad Autónoma de Zacatecas, Zacatecas, México
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Laboratorio de Radiobiología, Unidad Académica de Estudios Nucleares, Universidad Autónoma de Zacatecas, Zacatecas, México
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Laboratorio de Biología Celular y Neurobiología, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, México
1 Laboratorio de Biología Celular y Neurobiología, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, México
2 Laboratorio de Biología Celular y Neurobiología, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, México
3 Laboratorio de Radiobiología, Unidad Académica de Estudios Nucleares, Universidad Autónoma de Zacatecas, Zacatecas, México
4 Laboratorio de Radiobiología, Unidad Académica de Estudios Nucleares, Universidad Autónoma de Zacatecas, Zacatecas, México
5 Laboratorio de Biología Celular y Neurobiología, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, México
Ionizing radiations are tools in diagnosis and treatment of diseases. Leukopenia from exposure to ionizing radiation has been reported. Due to their radiosensitivity, leukocytes are a biological model to analyze cell damage. Therefore, cell viability, DNA damage, and Hsp70 and p53 expression in human leukocytes exposed to low-dose gamma radiation fields from a 137 Cs source were evaluated. A decrease in cell viability, DNA damage and an increase in the expression of Hsp70 and p53 proportional to the radiation dose received was found, which was 0.2, 0.4, 0.6, 0.8 and 1.0 mGy.
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