Background : Patients with cancer constitute a special group where immunization programs are often interrupted to begin treatment with chemotherapy. Sepsis is one of the main complications in this group. Methods : A hospital-based case-control study matched by age was carried out among subjects ≤ 9 years of age with cancer diagnosis. Children with cancer without sepsis and children with surgical pathology were included as controls; children with sepsis were included as cases. A bivariate logistic regression was used to determine the factors associated to nosocomial sepsis, and odds ratios were calculated with 95% confidence intervals. The percentage of attributable risk was calculated for the variables included in the final model. Results: Nineteen children with cancer and sepsis and 83 controls were included. Twelve (44%) caseshad an incomplete vaccination schedule according to their age. The association force between incomplete schedule and sepsis was 10.1 (95% CI, 3 - 36; p < 0.05). Conclusions : Approximately, 20% to 65% of the cases of serious nosocomial infection can be associated to an incomplete vaccination schedule. Strategies should be implemented to improve the general pediatric population’s vaccination status before a serious disease, such as cancer or another chronic condition preventing the application of vaccines, develops.
R. Wilkinson, “The Impact of Inequality: How to Make Sick Societies Healthier,” Preventing Chronic Disease, Vol. 3, No. 1, 2006, pp. A26.
A. P. de Leon, M. L. Garcia, M. C. Garcia, F. J. Gómez, J. L. Valdespino, G. Olaiz, R. Rojas, et al., “Tuberculosis and Diabetes in Southern Mexico,” Diabetes Care, Vol. 27, No. 7, 2004, pp. 1584-1590. doi:10.2337/diacare.27.7.1584
V. Richardson, J. Hernandez, M. Quintanar, M. Esparza, B. Johnson, C. M. Gomez, U. Parashar and M. Patel, “Effect of Rotavirus Vaccination on Death from Childhood Diarrhea in Mexico,” The New England Journal of Medicine, Vol. 362 , No. 4, 2010, pp. 299-305. doi:10.1056/NEJMoa0905211
D. A. Henderson, et al., “Smallpox as a Biological Weapon: Medical and Public Health Management,” Journal of the American Medical Association, Vol. 281, No. 22, 1999, pp. 2127-2137.
V. Racaniello, One Hundred Years of Poliovirus Pathogenesis,” Virology, Vol. 344, No. 1, 2006, pp. 9-16
M. L. NdeffoMbah, J. Liu, C. T. Bauch, Y. I. Tekel and J. Medlock, “The Impact of Imitation on Vaccination Behavior in Social Contact Networks,” PLoS Computational Biology, Vol. 8, No. 4, 2012, Article ID: 1002469. doi:10.1371/journal.pcbi.1002469
F. Feng, D. Rosenbloom, L. Wang and M. Nowak, “Imitation Dynamics of Vaccination Behavior on Social Networks,” Proceedings of the Royal Society B: Biological Sciences, Vol. 278, No. 1702, 2011, pp. 42-49.
N. Camille, M. Kotton and M. Poznansky, “Vaccination of Oncology Patients: An Effective Tool and an Opportunity Not to Be Missed,” The Oncologist, Vol. 17, No. 1, 2012, pp. 1-2. doi:10.1634/theoncologist.2011-0383
P. Loulergue, O. Mir, J. Alexandre, et al., “Low Influenza Vaccination Rate among Patients Receiving Chemotherapy for Cancer,” Annals of Oncology, Vol. 19, No. 9, 2008, p. 1658. doi:10.1093/annonc/mdn531
S. G. Martin, M. D. Mannino, S. Eaton and M. Moss, “The Epidemiology of Sepsis in the United States from 1979 through 2000,” The New England Journal of Medicine, Vol. 348, 2003, pp. 1546-1554. doi:10.1056/NEJMoa022139
A. G.Freifeld and P. Pizzo, “Infectious, Complications in the Pediatric Cancer Patients,” In: P. Pizzo and D. Poplack, Eds., Principles and Practice of Pediatric Oncology, JB Lippincott Co., Filadelfia, 1993, pp. 987-992.
V. Y. Dombrovskiy, A. A. Martin, J. Sunderram and H. L. Paz, “Rapid Increase in Hospitalization and Mortality Rates for Severe Sepsis in the United States: A Trend Analysis from 1993 to 2003,” Critical Care Medicine, Vol. 35, No. 5, 2007, pp. 1244-1250. doi:10.1097/01.CCM.0000261890.41311.E9
D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo and M. R. Pinsky, “Epidemiology of Severe Sepsis in the Unites States: Analysis of Incidence Outcome, and Associated Cost of Care,” Critical Care Medicine, Vol. 29, No. 7, 2001, pp. 1303-1310. doi:10.1097/00003246-200107000-00002
F. R. Avila, G. L. Ramírez, A. C. Alpuche, G. J. L. Arredondo and P. J. I. Santos, “Infecciones Nosocomiales en un Hospital Pediátrico,” Salud Publica de México, Cuernavaca, 1986.
A. G. Martínez, A. C. Anaya and F. C. Avila, “Incidencia de Bacteriemia y Neumonía Nosocomial en una Unidad de Pediatría,” Salud Publica de México, Cuernavaca, 2001. doi:10.1590/S0036-36342001000600001
Instituto Nacional de Estadística y Geografía (INEGI) “Secretaría de Salud/Dirección General de Información en Salud, Base de Datos de Defunciones 2000-2008,” INEGI, Aguascalientes, 2010.
B. Goldstein, B. Giroir, A. Randolph, et al., “International Pediatric Sepsis Consensus Conference: Definitions for Sepsis and Organ Dysfunction in Pediatrics,” The Pediatric Critical Care Medicine, 2005, Vol. 6, No. 1, 2005, pp. 2-8.
J. S. Garner, W. R. Jarvis, T. G. Emori, T. C. Horan and J. M. Hughes, “CDC Definitions for Nosocomial Infections. In: R. N. Olmsted, ed., APIC Infection Control and Applied Epidemiology: Principles and Practice, Mosby, St. Louis, 1996, pp. A1-A20.
J. V. Jani, C. De Schacht1, I. V Jani and G. Bjune, “Risk factors for Incomplete Vaccination and Missed Opportunity for Immunization in Rural Mozambique,” BMC Public Health, 2008, Vol. 8, No. 2, p. 161. doi:10.1186/1471-2458-8-161
Centers for Disease Control and Prevention, “Prevención y Control de la influenza con Vacunas: Recomendaciones del Comité Asesor Sobre Prácticas de Inmunización (ACIP) 2011,” 2011 Morbidity and Mortality Weekly Report (MMWR), Druid Hills, 2011.
Centers for Disease Control and Prevention, “Prevención y Control de la Influenza con Vacunas: Recomendaciones del Comité Asesor Sobre Prácticas de Inmunización (ACIP) 2010,” 2010 Morbidity and Mortality Weekly Report (MMWR), Druid Hills, 2010.
G. L. G. Montalván, “Sepsis Severa y Shock Séptico en el Nino. Aún no Todo Está Dicho,” Pan American Journal of Public Health, Vol. 26, No. 6, 2009, pp. 562-564.
F. J. Reyna, L. C. V. Richardson and V. P. Vidal “De las Definiciones, las Vacunas y la Identificación del Paciente Séptico en Pediatría,” Pan American Journal of Public Health, Vol. 27, No. 6, 2010, pp. 469-470. doi:10.1590/S1020-49892010000600010
T. Lehrnbecher, C. Foster, N. Vázquez, C. L. Mackall and S. J. Chanock, “Therapy-Induced Alterations in Host Defense in Children Receiving Therapy for Cancer,” Journal of Pediatric Hematology/Oncology, Vol. 19, No. 5, 1997, pp. 399-417. doi:10.1097/00043426-199709000-00001
P. A. Pizzo, “Management of Fever in Patients with Cancer and Treatment-Induced Neutropenia,” The New England Journal of Medicine 1993; Vol. 328, No. 18, pp. 1323-1332. doi:10.1056/NEJM199305063281808
R. N. Jones, “Contemporary Antimicronial Susceptibility Pattems of Bacterial Pathogens Commonly Assoclated with Febrile Patients with Neutropenia,” Clinical Infectious Diseases, Vol. 29, No. 3, 1999, pp. 495-502. doi:10.1086/598621
M. Macias, G. A. Jarquin, P. Gutierrez, M. A. Rodriguez, N. Gonzalez and P. Saltigeral, “Factores de Riesgo para Esquemas de Vacunación Incompletos en Ninos de 6 a 60 Meses en el Instituto Nacional de Pediatría,” Revista de Enfermedades Infecciosas en Pediatría, Vol. 22, No. 86, 2008, pp. 41-47.
E. Holt, B. Guyer, N. Hughart, et al., “The Contribution of Missed Opportunities to Childhood Immunization in Baltimore,” Pediatrics, Vol. 97, No. 4, 1996, pp. 474-480.