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International Journal of Organic Chemistry (IJOC) is an international, specialized, English-language journal devoted to publication of original contributions concerning all field of organic chemistry. It is an open-access, peer-reviewed journal describing the synthetic approached and the design of new molecules for ap…
Michѐle-L. Lieunang Watat, Jovita S. Chi, Claudia E. Asanji, Emmanuel N. Nfor
Two novel dopamine hydrochloride Schiff bases ( E )-4-(2-((4-hydroxy-2 H -chromen-2-ylidene)amino)ethyl)benzene-1,2-diol ( 1 ) and ( E )-3-((3,4-dihydroxyphenethyl)imino)indolin-2-one ( 2 ) have been synthesized using isatin and 4-hydroxycoumarin. The prepare…
Mo’men Salem, Rezk Ayyad, Helmy Sakr, Ahmed Gaafer
In this work we synthesized new derivatives from Phenyl Hydrazine and series of different Aldehydes (derivatives of benzylidenes). The synthesized compounds contain different aromatic Aldehydes which attached by Benzene ring via Hydrazine moiety in glacial ac…
Deniz Saglam, Zuhal Turgut
Synthesis of uracil derivatives, such as pyrido[2,3- d ]pyrimidine, is very important for the pharmaceutical industry due to their many biological activities. In our continuing efforts into the development of new synthetic strategies for the preparation of he…
Yutaka Okada, Yoshiharu Kato
Ligand exchange reaction is one of the typical reactions of ferrocene. In this paper, ligand exchange reactions were carried out between ferrocene and var ious substituted benzenes using aluminum chloride catalysis. The product yields of the reactions with al…
Souad Akili, Djamila Ben Hadda, Yaser Bitar, Amir Balash, Mustapha Fawaz Chehna
Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TMLR) (PDB ID: 5EDQ) to identify new drug ca…
Khidir Tajelseir Othman, Nibras Ahmed Elaas
2-Isoxazolines and 2-pyrazolines have been derived from oxime and hydrazone derivatives reacted with N -chlorosuccinimide (NCS) and trichloroisocyanuric acid (TCCA). Cyclization strategy is developed for the reaction of β , γ -unsaturated hydrazones with the…
Souad Akili, Djamila Ben Hadda, Yasser Bitar, Abdulkarim Najjar, Mustapha Fawaz Chehna
Several novel sulfonamide-derivatives were designed and studied their physicochemical properties to develop novel kinase inhibitors. Therefore, molecular docking was performed for the designed compounds against epidermal growth factor receptor (PDB ID: 2ITY)…
Helmy M. Sakr, Rezk R. Ayyad, Kazem Mahmoud, Ahmed M. Mansour, Ahmed. G Ahmed
T his work, contain s some new compounds from benzimidazole derivatives, which are synthesized by condensation of Orthophenylene diamine and Carbon disulfide resulting in 2-Mercapto-benzimidazole which is treated by alcoholic potassium hydroxide forming potas…
Eman Nabil, Tawfik Khattab, Samir Kamel
Textiles are among the most fragile artefacts in the world. They are difficult to preserve even in the best circumstances. Herein, we studied an artefacts fabric of a special nature in terms of usage. Despite the multiple applications of textiles, the piece u…
Rasha Ghanem Kattoub, Faten Sliman, Mohammad Kousara
The serine/threonine Akt kinase signaling pathway plays an essential role not only in tumorigenesis but also in the potential response to anticancer therapeutic agents. Therefore, aiming to identify potent and selective Akt inhibitors, a novel series of benzi…
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International Journal of Organic Chemistry (IJOC) is an international, specialized, English-language journal devoted to publication of original contributions concerning all field of organic chemistry. It is an open-access, peer-reviewed journal describing the synthetic approached and the design of new molecules for ap… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
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