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JCT is an international journal dedicated to the latest advancements in cancer therapy. The goal of this journal is to provide a platform for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in cancer related problems. All manuscripts must be prepared in En…
Nicoletta Staropoli, Cirino Botta, Domenico Ciliberto, Lucia Fiorillo, Antonina Maria De Angelis, Caterina Viscomi, Simona Gualtieri, Angela Salvino, Pierfrancesco Tassone, Pierosandro Tagliaferri
Epithelial ovarian cancer (EOC) is the sixth most common malignancy in women. Ovarian tumors consist of several clinical and pathological entities that share an anatomic site. The gold standard treatment, both in front-line and in ad juvant setting, is repres…
Hoda Rahmani, Mohsen Korani, Mohamad Reza Sarasgani, Hamid Reza Fathi, Pedram N. Mohamadpoor
Oxidative status assessment is an initial step in tumor related studies. To the best of our knowledge, this is the first study consider ing oxidative activity of both serum and tissue specimens in human basal cell carcinoma (BCC), which is the most common tum…
Hengning Ke, Ramin Massoumi
Dysregulation of components of the ubiqutin system ha s been linked to many diseases including melanoma. This is vital since the post-translational modification of different proteins via direct ubiquitin attachment is an important process for various cellular…
Karen-Lise Garm Spindler, Niels Pallisgaard, Rikke Fredslund Andersen, John Ploen, Anders Jakobsen
Introduction : We investigated the safety and efficacy of pemetrexed with gemcitabine in heavily pre-treated, chemotherapy refractory, KRAS mutated colorectal cancer (mCRC) and the prognostic value of quantitative levels of cell free DNA (cfDNA) in plasma. Me…
Vermont P. Dia, Elvira Gonzalez de Mejia
Lunasin is a bioactive peptide originally isolated from soybean and has demonstrated chemopreventive and anti-cancer properties against skin, colon and breast cancers. The objective of the study was to evaluate the capability of intraperi toneally and orally-…
Mariana Bianchi, Javier Adur, Maria F. Izaguirre, Silvia Viale, Carlos L. Cesar, Víctor H. Casco
The endothelin family has been related with several pathological diseases including cardiovascular disorders, hypertension and cancer. However, little is known about endothelin system in early stages of colorectal cancer and there are no studies evaluating di…
Janeth I. Sanchez, Rebecca Palacios, Beti Thompson, Vanessa Martinez, Mary A. O’Connell
Purpose: Colorectal cancer (CRC) mortality rates in New Mexico (NM) continue to be higher than national rates. Hispanic CRC mortality rates in NM surpass those of overall Hispanics in the US. This study was designed to characterize and understand factors cont…
Masataka Ikeda, Mitsugu Sekimoto, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori
Background: We evaluated the feasibility and efficacy of irinotecan (CPT-11) plus tegafur/uracil (UFT) combination chemotherapy in patients with advanced colorectal cancer. Patients and Methods: PK parameters were concurrently measured to confirm the presence…
Anestakis Doxakis, Argyraki Maria, Petanidis Savvas, Iakovidou-Kritsi Zafiroula
Cysteine cathepsins are important regulators and signaling molecules of an unimaginable number of biological proc esses, while they concurrently play an essential role in cancer progression, invasion and metastasis. The purpose s of our study w ere to : a) co…
Mark S. Walker, Lee S. Schwartzberg, Diana M. Chen, D. Devi Ramanan, Arthur C. Houts, Carolina Reyes
Advanced basal cell carcinoma (aBCC) includes metastatic and locally advanced BCC that is inoperable (or with sur gery contraindicated). We describe patient characteristics and treatment history for aBCC cases from community on cology. Nine cases of aBCC were…
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JCT is an international journal dedicated to the latest advancements in cancer therapy. The goal of this journal is to provide a platform for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in cancer related problems. All manuscripts must be prepared in En… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
Authors submit their manuscript, metadata, and declarations through the portal. There is no submission fee.
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At least two independent reviewers evaluate the manuscript under single-blind review. Where revisions are required, authors respond point by point.
On acceptance the article processing charge is invoiced and the CC BY 4.0 copyright handover is signed.
The article is copyedited, typeset, and given a DOI, then publishes open access with a permanent link.
Manuscripts must be original and not under consideration elsewhere. Submit in Microsoft Word or LaTeX with figures at 300 dpi minimum. Structure research articles as Abstract, Introduction, Methods, Results, Discussion, and References.
Use the journal's numbered (Vancouver) reference style. Cite sources consecutively in the order they appear, and ensure every reference is complete and retrievable.
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