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Call for papersThe 2026 special issue on Climate & Health is open for submissions.Learn more
JCT is an international journal dedicated to the latest advancements in cancer therapy. The goal of this journal is to provide a platform for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in cancer related problems. All manuscripts must be prepared in En…
Robert L. Satcher, Oluwatosin Bamidele, Patrick Lin, Sue-Hwa Lin, Bryan Moon, Mike Hernandez, Valerae Lewis, Janice Chilton
Introduction: This study reviewed patients’ demographic, clinical and treatment characteristics to identify prognostic factors associated with survival of prostate cancer after developing bone metastases. We explored the racial disparities in these factors an…
Lilach Agemy, Itai Kela, Tova Waks, Raphael M. Pfeffer, Anat Bar-Shira, Avi Orr-Urtreger, Eytan Domany, Zelig Eshhar
Ionizing radiation (IR) is the most common treatment used to control localized primary prostate cancer (PC). However, for a significant number of patients, radiotherapy fails to adequately control the tumor. Thus, a main clinical problem today is the lack of…
Paulina Pechańska, M. Becker, T. Mayr, B. Hinzmann, H.-P. Adams, I. Klaman, K.-H. Kretschmar, K. Kretschmar, K. Stecker, R. Mantke, R. Pauli, J. Pertschy, K. Hertel, K. Ridwelski, K. Hellwig, M. Pross, C. Radke, I. Fichtner, J. Hoffmann, A. Rosenthal
To advance preclinical testing of novel targeted drugs in colorectal cancer (CRC) we established a panel of 133 mouse xenograft models from fresh tumor specimens of 239 patients with CRC of all four UICC stages. A subgroup of 67 xenograft models was treated w…
Saleem Farooqui, Natarajan Ravendhran, Steven C. Cunningham
The incidence of hepatocellular carcinoma (HCC) is rising worldwide. Although the best chance for long-term survival is early detection, screening high-risk populations to detect HCC when it is most treatable still has only limited success. Once detected with…
Jens Jaeger, Lothar Weißbach, Holger Pfaff, Nicole Ernstmann
Purpose: Many studies demonstrate the importance of an empathic communication with prostate cancer patients and show various information needs. Most of the studies are cross sectional. The present analysis aims to 1) provide detailed prospective data on the a…
Joseph Kattan, Hampig Kourie, Pierre Sarkis, Joseph Gharios, Joelle Antoun
Small cell prostate carcinoma (SCPC) is an extremely rare pathology with an aggressive behavior, characterized by early brain metastases. We describe three cases of SCPC where brain metastases occurred despite response to chemotherapy. The benefit of prophyla…
Ioannis Tourkantonis, Maria Kiagia, Evangelia Peponi, Sophia Tsagouli, Konstantinos N. Syrigos
Leptin is a hormone produced and secreted by adipose tissue. It is a member of adipokine family with a principal role in body weight regulation. It is reported that low brain leptin levels enhance the activity of hypothalamic orexigenic sig nals promoting fee…
Soichiro Uehara, Katsuhiro Gotoh, Hiroshi Handa, Yoshiyuki Maki
The aim of this study was to determine the plasma levels of vitamin K-dependent protein growth arrest-specific protein 6 (Gas6) and its soluble receptor Axl (sAxl) in patients with hepatocellular carcinoma (HCC), acute hepatitis (AH), fulminant hepatitis(FH),…
Anna C. Krelle, Arinze S. Okoli, George L. Mendz
In the last decades, the use of in vitro systems in liver research has grown exponentially. Important reasons promoting this work are the high throughput and ease of genetic manipulations afforded by these experiments relative to in vivo experiments. Thousand…
Nadine Rudiger, Ernst-Ludwig Stein, Erika Schill, Gabriele Spitz, Carola Rabenstein, Martina Stauch, Matthias Rengsberger, Ingo B. Runnebaum, Ulrich Pachmann, Katharina Pachmann
Background: Chemotherapy is a mainstay of tumor therapy, however, it is predominantly applied according to empiri cally developed recommendations derived from statistical relapse rates occurring years after the treatment in the adju vant situation and from pr…
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JCT is an international journal dedicated to the latest advancements in cancer therapy. The goal of this journal is to provide a platform for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in cancer related problems. All manuscripts must be prepared in En… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
Authors submit their manuscript, metadata, and declarations through the portal. There is no submission fee.
The editorial office screens the manuscript for scope, completeness, and formatting before assigning a handling editor.
At least two independent reviewers evaluate the manuscript under single-blind review. Where revisions are required, authors respond point by point.
On acceptance the article processing charge is invoiced and the CC BY 4.0 copyright handover is signed.
The article is copyedited, typeset, and given a DOI, then publishes open access with a permanent link.
Manuscripts must be original and not under consideration elsewhere. Submit in Microsoft Word or LaTeX with figures at 300 dpi minimum. Structure research articles as Abstract, Introduction, Methods, Results, Discussion, and References.
Use the journal's numbered (Vancouver) reference style. Cite sources consecutively in the order they appear, and ensure every reference is complete and retrievable.
Declare all funding sources, conflicts of interest, and ethical approvals (including informed consent and animal-care statements where applicable).