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Open Journal of Immunology (OJI) is an international journal dedicated to the latest advancements in immunology. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of immunology. All…
Ramaseri Sunder Sharada, Hanumanth Surekha Rani, Satya Sudheer Pydi, Jonnalagada Subbanna, Vijaya lakshmi Valluri
CD38 expression on CD8+ cells seems to correlate well with HIV viral-loads, while the ex-pression levels are thought to be low in patients with tuberculosis. This study aimed at determining the levels of CD38 expression in HIV+ individuals who develop tubercu…
James D. Thacker, Carol M. Artlett
Antibiotic therapy has been of unquestionable value in terms of saving lives and reducing suffering caused by infectious diseases. However, the widespread and indiscriminant use of antibiotics has not been without significant consequences. Some of these conse…
Olga Moiseeva, Lubov Mitrofanova, Elena Karelkina, Dmitry Zverev, Dmitry Lebedev, Serge Skurydin, Alexander Poletaev
We analyzed profiles of IgG autoantibodies to 16 cardiac specific proteins and their main immunogenic region B-epitopes, in the groups of already verified cardiac pathology: acute and chronic lymphocytic myocarditis, ST elevation myocardial infarction, postin…
Morten Breindahl, Klaus Rieneck, Claus Nielsen, Tage Justesen, Klaus Bendtzen, Klaus Müller
Introduction: Variability in severity of Respiratory Syncytial Virus (RSV) infection is reportedly due to differences in inflammatory response. Objective: To characterize the cytokine response in RSV+ infants aged 0 - 36 months and to relate their responses t…
Yu Qiao, Brian M. Gray, Mohammed H. Sofi, Laura D. Bauler, Kathryn A. Eaton, Mary X. D. O’Riordan, Cheong-Hee Chang
We have reported a new innate-like CD4 T cell population that expresses cell surface makers of effector/memory cells and produce Th1 and Th2 cytokines immediately upon activation. Unlike conventional CD4 T cells that are selected by thymic epithelial cells, t…
Matthias J. Duechs, James E. Brunt, Florian Gantner, Klaus J. Erb
Currently different Toll-like receptor (TLR) agonists are tested in humans for their ability to enhance the efficacy of specific immunotherapy (SIT). Recent clinical data suggest that this may be achieved by increasing allergen-specific Th1 responses. However…
Masaaki Hashiguchi, Yuka Inamochi, Shoya Nagai, Noriko Otsuki, Jinhua Piao, Hiroko Kobori, Yumiko Kanno, Hidefumi Kojima, Tetsuji Kobata, Miyuki Azuma
The B7 family member B7-H3 is broadly expressed in many tissue and tumor types. B7-H3 expression is induced on some immune cells; however, its immunological function remains controversial, because both immunoenhancing and immunoinhibitory effects have been re…
Xin Wang, Toshihiko Fukamachi, Hiromi Saito, Hiroshi Kobayashi
Clustering is a basic event for the initiation of immune cell responses, and simulation analyses of clustering of membrane proteins have been performed. It was claimed that a cluster is formed by the self-assembly induced by protein dimerization with a high b…
Viviane Balloy, Heidi Nagel, Reuben Ramphal, Mustapha Si-Tahar, Michel Chignard
Background: We previously showed that MyD88 knocked out mice were protected from death due to B. cenocepacia pneumonia implying that a toll-like receptor(s) (TLR) was involved in mediating death. The aim of the present study was to determine which TLR(s) was…
Rubina Naqvi, Salma Batool Jafri, Zahabia Imani, Mohammad Mubarak, Rana Muzaffar
Background: An accurate diagnosis of cause of acute renal graft dysfunction is crucial for the optimal management of transplant recipients. Currently available tests are either insensitive or nonspecific, or are invasive, such as allograft biopsy. During last…
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Open Journal of Immunology (OJI) is an international journal dedicated to the latest advancements in immunology. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of immunology. All… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
Authors submit their manuscript, metadata, and declarations through the portal. There is no submission fee.
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At least two independent reviewers evaluate the manuscript under single-blind review. Where revisions are required, authors respond point by point.
On acceptance the article processing charge is invoiced and the CC BY 4.0 copyright handover is signed.
The article is copyedited, typeset, and given a DOI, then publishes open access with a permanent link.
Manuscripts must be original and not under consideration elsewhere. Submit in Microsoft Word or LaTeX with figures at 300 dpi minimum. Structure research articles as Abstract, Introduction, Methods, Results, Discussion, and References.
Use the journal's numbered (Vancouver) reference style. Cite sources consecutively in the order they appear, and ensure every reference is complete and retrievable.
Declare all funding sources, conflicts of interest, and ethical approvals (including informed consent and animal-care statements where applicable).