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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP…
Cheng H. Yen, Adil Mohammad, Miah Schneider, Salwa K. Poole, Bryan Lowry, Brenda W. Mc Curdy, Patrick J. Faustino, Saeed R. Khan
The development and implementation of advanced analytical technologies is essential for extending the expiry for complex drug products stored in the Strategic National Stockpiles. Consequently, a novel Ultra High-Performance Liquid Chromatographic (UHPLC) met…
Sumit Bhatt, Gajendra Singh, Sanjeev Kumar, Rachna Paliwal, Jeet Singh Jangwan, Chandra Pal Singh
A series of sulpha/substituted derivatives of phenyl azo-1,2-diazole have been synthesized and tested as an anti-inflammatory and anti-bacterial activity in mature albino rats hind paw by taking Diclofenac sodium as standard. N 1 -(4-hydroxy benzoyl)-3-methyl…
Yoshiaki Kimura, Koki Muryoi, Mika Shibata, Noriyuki Ozaki, Kunizo Arai
The number of studies on possible pharmacokinetic interactions between opioid analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used in combination for the treatment of chronic pain, is limited. In rats, the major metabolic path…
Shinya Mizuno, 1 1, Yoko Mizuno-Horikawa
Hyperkalemia is one of the most important risk factors in patients suffering from crush syndrome with rhabdomyolysis. Glycerol-injected animals have been used as an experimental model of rhabdomyolysis-induced acute kidney injury (AKI), but little information…
Abdulaziz Almulhim
Background: Nosocomial infection remains an important contributing factor for morbidity and mortality in neonates. Coagulase-negative staphylococci have emerged as the predominant pathogens of late onset sepsis. This is followed by staphylococcus aurous, gram…
Sanah Hasan, Ghazaleh Farghadani, Salaa Khalid AlHaideri, Mohamed Abdelraouf Fathy
Objective : Self-treatment is an important aspect of self-care and one of the vital issues under debate in health care. Self-medication patterns vary among different populations and are influenced by many factors. The objective was to investigate the nature o…
Marwa E. Sayour, Rania M. Abd El Salam, Mohamed F. Elyamany, Abeer M. El Sayed, Raafat A. El-Awady
Background : Paracetamol exerts toxic effects on liver cells through its metabolism into N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by conjugation with cellular glutathione (GSH). Once GSH is depleted, NAPQI stimulates a range of oxidative rea…
Wilfried Dimpfel, Gwladys N. Chiegoua Dipah, Samir Suliman
The pharmaco-dynamic action of plant-derived drugs still remains a big challenge in the field of pharmacology. This applies especially for the discovering of the possible mechanism of action. With respect to the brain, surrogate parameters may be very helpful…
Hideo Kato, Mao Hagihara, Yuka Yamagishi, Yukihiro Hamada, Jun Hirai, Naoya Nishiyama, Yusuke Koizumi, Katsuhiko Matsuura, Hiroshige Mikamo
Previous study suggested that low body weight was one of the risk factors of thrombocytopenia induced by linezolid in non-hemodialysis patients. However, there have been little investigations for the linezolid-induced thrombocytopenia in hemodialysis patients…
Wilfried Dimpfel, Leonie Schombert, Björn Feistel
A hydroethanolic extract (20% V/V) from Herba Sideritis scardica has been recognized to positively influence cognition. The present investigation aimed at the question if this extract would be able to modify intra-hippocampal communication after oral administ…
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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
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