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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP…
Jiann-Jy Chen, Dem-Lion Chen
An 82-year-old male suffered from prostatic cancer five years ago. Since then, he has taken flutamide and was bothered with episodic vertigo (EV) every morning. In order to treat prostatic cancer, flutamide was not discontinued, but conservative treatment and…
Ruzilawati Abu Bakar, Mohd Suhaimi Ab Wahab, Imran Ahmad, Gan Siew Hua
This study was conducted to evaluate the effect of sex differences on the pharmacokinetics of repaglinide in healthy subjects. One hundred twenty one healthy volunteers (61 male and 60 female; aged 18 - 50 years) were included in the study. Subjects were admi…
David Crouzier, Jean-Claude Debouzy, Florian Nachon, Dominique Debouzy, Guy Lallement, Frédéric Canini
Metyrapone (2-methyl-1,2-di-3-pyridyl-1-propanone) is a drug largely used as inhibitor of glucocorticoid synthesis. Although its binding to various proteins has been well indentified, its accurate molecular mechanism of action remains unknown. Therefore, the…
Shinichi Takahashi, Yoshikane Izawa, Norihiro Suzuki
Cilostazol, a potent inhibitor of type 3 phosphodiesterase (PDE3), has recently been reported to exert neuroprotective effects during acute cerebral ischemic injury. These effects are, at least in part, mediated by the inhibition of oxidative cell death. Howe…
Mai Hazekawa, Yoshiki Sakai, Miyako Yoshida, Tamami Haraguchi, Takahiro Uchida
ONO-1301 has been developed as a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. In the present study, we investigated the cerebroprotective effect of ONO-1301 on post-ischemic injury induced by cerebral ischemia in rats.…
Jyoti Gupta, Jason Qihai Tao, Sanjay Garg, Raida Al-Kassas
Vaginal dosage forms are seen as a viable option for empowering women to protect themselves from the risk of HIV transmission. Because of limited research in the field, there is a lack of suitable dissolution methods established for determination of drug rele…
Tan Nhut Doan, Dao Thanh Tran
A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate. The s…
Vijay K. Agrawal, Basheerulla Shaik, Padmakar V. Khadikar, Shalini Singh
Quantitative Structure-Activity Relationship (2D-QSAR) models for binding affinity constants (log K<i>i</i>) of 78 flavanoid ligands towards the benzodiazepine site of GABA (A) receptor complex were estimated using the PRECLAV (Property-Evaluation by Class Va…
Noriko Yoshikawa, Arisa Nishiuchi, Erika Kubo, Yu Yamaguchi, Masaru Kunitomo, Satomi Kagota, Kazumasa Shinozuka, Kazuki Nakamura
Cordyceps sinensis, a parasitic fungus on the larva of Lapidoptera, has been used as a traditional Chinese medicine. We previously reported that the growth of B16-BL6 mouse melanoma (B16-BL6) cells and mouse Lewis lung carcinoma (LLC) cells was inhibited by c…
Enri Borda, Daniela Passafaro, Silvia Reina, Leonor Sterin-Borda
Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH<sub>2</sub> terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) present in the sera of pat…
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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
Authors submit their manuscript, metadata, and declarations through the portal. There is no submission fee.
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At least two independent reviewers evaluate the manuscript under single-blind review. Where revisions are required, authors respond point by point.
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Manuscripts must be original and not under consideration elsewhere. Submit in Microsoft Word or LaTeX with figures at 300 dpi minimum. Structure research articles as Abstract, Introduction, Methods, Results, Discussion, and References.
Use the journal's numbered (Vancouver) reference style. Cite sources consecutively in the order they appear, and ensure every reference is complete and retrievable.
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