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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP…
Ighodaro Igbe, Eric.K.I. Omogbai, Adebayo.O. Oyekan
Many agents are known to cause qualitative and quantitative differences in intrarenal blood flow. This study tested the hypothesis that angiotensin II (AII) evokes a differential effect on cortical (CBF) and medullary blood flow (MBF) and that AT 2 receptor m…
Khalid A. J. Al Khaja, Mohammed K. Al-Haddad, Reginald P. Sequeira, Adel R. Al-Offi
The aim of this study is to determine the antipsychotic prescribing pattern and the prevalence of concurrent anticholinergic prescribing in a psychiatric referral hospital. A retrospective audit of prescriptions issued for outpatients was carried out at the P…
Sam T. Mathew, Gayathri Devi S, Prasanth V. V, Vinod B
Antiplatelet therapy, which reduces platelet activation and aggregation, is the corner stone of treatment for patients undergoing percutaneous coronary intervention (PCI). Clopidogrel is an established oral antiplatelet medication of thienopyridine class, whi…
Osama H. Mohamed Ibrahim, Suleiman El-Sharif
Background: The present study was undertaken to investigate the patterns of drug and antibiotics prescribing in a teaching hospital in Cairo, Egypt. Aim: to determine the impact of interventions on such trends in an attempt to rationalize drug use. Method: 12…
Robert B. Raffa, Christopher S. Tallarida, Aruj Choudhry, Nadia Sanni-Adam, Sean McGonigle, Michael Baron, Zhuo L. Chen, Scott M. Rawls, Ronald J. Tallarida
Based on previous work, it has been hypothesized that the energetics of ultraviolet (UV) light disrupts effects induced by receptor-binding ligands. If this hypothesis is true, then UV light should (i) disrupt a broad variety of endpoints and (ii) disrupt eff…
Sergey Afanasiev, Dina Kondratyeva, Sergey Popov, Roman Batalov
Change of interval–force dependence of rat papillary muscles at acute and course use of amiodarone was investigated. Methods. The experiments were performed on isolated papillary muscles of Wistar rats. The extrasystolic (0,2-1,5 s), postextrasystolic contrac…
Elias Adikwu, Oputiri Deo
Fluoroquinolones are known to be safe and well tolerated. They are said to have the widest clinical acceptability when compared with other antibiotics. Their reported side effects include gastrointestinal tract, central nervous system effect and blood disorde…
Kang Li, Xiaohua Zhu, Yong Liang
A novel voltammetric sensor based on gold nanoparticles (GNPs) and single-walled carbon nanotubes (SWNTs) composite was developed. The nanocomposite modified electrode was characterized using atoms force microscope (AFM). The electrochemical behavior of meclo…
Robert B. Raffa
Several preclinical and clinical studies suggested that tramadol has a multi-mechanistic analgesic action. Upon in vitro evaluation, tramadol parent drug was determined to have only very weak affinity for opioid receptors. Metabolism via CYP2D6, though, yield…
Niraldo Paulino, Amarilis Scremin Paulino, Priscila Vaultier, Laura Pisco, Carolina Passarelli, José Matheus de Freitas Costa, Dirk Michalik, Paulo Celso Pardi, José Agustín Quincoces Suárez
This work describes the synthesis, antinociceptive and anti-inflammatory effect of O -prenyl derivatives: O -prenyl derivatives 2-(3-methylbut-2-enyloxy)acetophenone (L1) and 3-methoxy-4-(3-methylbut-2-enyloxy)benzaldehyde (V1). Treatment with L1- or V1-produ…
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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
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