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Call for papersThe 2026 special issue on Climate & Health is open for submissions.Learn more
JCT is an international journal dedicated to the latest advancements in cancer therapy. The goal of this journal is to provide a platform for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in cancer related problems. All manuscripts must be prepared in En…
Jonathan Pottle, Chengrong Sun, Lloyd Gray, Ming Li
The purpose of this study is to demonstrate MCF-7 cells’ dependence on calcium for growth and to exploit that de pendence to improve chemotherapy efficacy. Fura-2 fluorescence imaging shows that MCF-7 cells maintain a higher basal intracellular calcium concen…
Chellakkan Selvanesan Benson, Somasundaram Dinesh Babu, Selvi Radhakrishna, Nagarajan Selvamurugan, Bhaskaran Ravi Sankar
Growth factor signaling plays a key role in the growth and development of breast. Aberrant expression and activation of growth factors like insulin like growth factor-I (IGF-I) and epidermal growth factor (EGF) and their downstream sig naling has been implica…
Ozgur Emre, Halit Demir, Erkan Dogan, Ramazan Esen, Tugba Gur, Canan Demir, Edip Gonullu, Nedim Turan, Mehmet Fatih Özbay
Purpose : It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated i…
Jordan Troxel, Grace Brummer, Kristin Cox, S. Ray Peterson
Mohs Micrographic Surgery (MMS) is widely employed in the treatment of non-melanoma skin cancer and is a pre ferred treatment for many cutaneous malignancies, particularly in high risk locations and tumors [1 , 2]. It has also been used in the narrow excision…
Edward V. Quadros, Yasumi Nakayama, Jeffrey M. Sequeira
Cobalamin uptake into cells is mediated by the CD 320 receptor for transcobalamin-bound cobalamin. Optimum rec e p tor expression is associated with proliferating cells and therefore, in many cancers this receptor expression is up regu lated. Delivering drugs…
Gabriella Uhercsák, Ágnes Dobi, Roland Gyulai, Judit Oláh, László Kaizer, Katalin Ormándi, Adrienne Cserháti, György Lázár, Gyula Farkas, Zsuzsanna Kahán
The case of a young female patient with metachronous primary melanomas, advanced breast and pancreatic cancers is reported. The 5 different tumors diagnosed within six years, were managed with curative intent. Genetic analysis re vealed the mutation of the R2…
Xianyong Gui, Shuhong Liu, Ziran Meng, Zu-Hua Gao
Neurotensin (NT) is a 13-amino acid peptide with trophic effects on some neoplasms. Its bioactivities are mainly medi ated by neurotensin receptor 1 (NTSR1). Both NT and NTSR1 were found to be upregulated in breast cancer. NT/NTSR1 thus becomes a potential th…
Andee Dzulkarnaen Zakaria, Nur Farhana Abd Salam, Wan Zainira Wan Zain, Mohd Nizam Hashim
The diagnosis of breast cancer can cause a significant anxiety in someone’s life. The care of the breast cancer patient requires in many centres . The care of breast cancer patient is undertaken as a joint venture between the surgeon, medical oncologist, radi…
Luisa Sugaya, Paulo R. de Alcantara Filho, Bruna Salani Mota, Sujata Patil, Kimberly J. Van Zee, José Luiz B. Bevilacqua
Memorial Sloan-Kettering Cancer Center (MSKCC) has developed 2 nomograms: the Sentinel Lymph Node Nomo gram (SLNN), which is used to predict the likelihood of sentinel lymph node (SLN) metastases in patients with invasive breast cancer, and the Non-Sentinel L…
Hisato Kawakami, Isamu Okamoto, Wataru Okamoto, Masayuki Takeda, Shinya Ueda, Toshihiro Kudo, Shin-ichi Nishina, Yasuhito Fujisaka, Masaki Miyazaki, Junji Tsurutani, Takayasu Kurata, Kazuhiko Nakagawa
Gemcitabine and cisplatin combination therapy (GC) is accepted as a standard treatment for advanced biliary tract can cer (BTC). However, little information is available regarding such treatment in the clinical practice setting in Japan. We retrospectively ex…
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JCT is an international journal dedicated to the latest advancements in cancer therapy. The goal of this journal is to provide a platform for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in cancer related problems. All manuscripts must be prepared in En… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
Authors submit their manuscript, metadata, and declarations through the portal. There is no submission fee.
The editorial office screens the manuscript for scope, completeness, and formatting before assigning a handling editor.
At least two independent reviewers evaluate the manuscript under single-blind review. Where revisions are required, authors respond point by point.
On acceptance the article processing charge is invoiced and the CC BY 4.0 copyright handover is signed.
The article is copyedited, typeset, and given a DOI, then publishes open access with a permanent link.
Manuscripts must be original and not under consideration elsewhere. Submit in Microsoft Word or LaTeX with figures at 300 dpi minimum. Structure research articles as Abstract, Introduction, Methods, Results, Discussion, and References.
Use the journal's numbered (Vancouver) reference style. Cite sources consecutively in the order they appear, and ensure every reference is complete and retrievable.
Declare all funding sources, conflicts of interest, and ethical approvals (including informed consent and animal-care statements where applicable).