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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP…
Cheng Peng, Yanhong Wang, Yunxia Li
Aim: To explore the emodin’s toxicity and action mechanism on the function of interstitial cells of Cajal (ICC) cultured in vitro . Methods: ICC of KM mouse was cultured in vitro . The minimum toxicity concentration and critical time points of emodin were inv…
Yoshifumi Murata, Takashi Isobe, Kyoko Kofuji, Norihisa Nishida, Ryosei Kamaguchi
Film dosage forms (FDs) containing miconazole (MCZ) for the treatment of oral candidiasis were prepared using water-soluble polysaccharides, and the dissolution profiles of MCZ from the FDs were investigated. In addition, the forms were modified by the additi…
Leo Niskanen, Janne Suvisaari, Jaana Suvisaari, Anna But, Jari Haukka
Purpose: The aim was to study discontinuation of statin treatment, especially with respect to clinical characteristics and adverse effect measured by clinical laboratory tests indicating muscle damage (plasma creatine kinase, CK) and liver AEs (plasma alanine…
Gladys Cossio, Alberto Bissot, Mireya de Rivas, Luis Morales, Paul Gallardo, David Ellis, Judith Hal
In the 1990s, misoprostol ( synthetic prostaglandin E1 analogue) was found to be an effective abortive agent when taken orally and became widely used in Latin America as a means to terminate unwanted pregnancies. A variety of congenital anomalies have been ob…
Ilhuicamina Daniel Limón-Pérez de León, María del Carmen Parra-Cid, Alejandro Muñoz-Zurita, Saúl Alejandro Merino-Contreras, Sara Montiel-Smith, Socorro Meza-Reyes, Gerardo Ramírez-Mejía, Jesús Sandoval-Ramírez
A series of 1,3-substituted 8-styrylxanthines ( 11a-d ) was synthesized, under chemo- and regioselective conditions, in a good overall yield. The compounds showed affinity towards both A 1 and A 2A -adenosine receptors by radioligand binding by means of in vi…
Songül Tezcan, Fikret Vehbi Izzettin, Mesut Sancar, Perran Fulden Yumuk, Serdar Turhal
Background: To evaluate cisplatin-induced nephrotoxicity in outpatients receiving chemotherapy with cisplatin alone or in combination with other agents using a short hydration method. Methods: Forty-nine patients enrolled in the study were monitored during 3…
Beatriz Vázquez-Cruz, Josseline Rangel-Veladiz, David Segura-Cobos, Pedro López-Sánchez, Maximiliano Ibarra-Barajas, Dante Amato
Diabetes mellitus is the leading cause of diabetic nephropathy; the early phase of diabetes is associated with kidney growth and hyperfiltration; several factors modulate these changes, among them, prostaglandins and angiotensin II. Previous studies have show…
Selma Gutierrez Antonio, Ariel Gomes, Fábio Furlan Ferreira, Gabriel L. B. Araujo, Carlos O. Paiva-Santos
Tibolone, a synthetic steroid, is used in the treatment of natural or surgical menopause disturbs resultant of estrogenic deficiency. Isotibolone (Δ 4 -tibolone) is one of the three active metabolic degradation products of tibolone that displays progestagenic…
Yao Lu, Wei Yu, Pingniang Shen, T. J. Khoo, C. Wiart
A high-performance liquid chromatographic method was applied to the determination of stachydrine hydrochloride concentration in TJF granule (Chinese name: Tiao-Jing-Fang), using a mobile phase of methanol - acetonitrile (50:50, v/v) by the Agilent Kromasi NH…
Min Lu, Ying Zhou, Yimin Cui
The aim of this article was to report a case of toe nails disorder associated with metformin use in an elderly patient with type2diabetes. Two years ago, after receiving metformin 0.5 g three times daily for 6 months, a 60-year-old Chinese man found his ten t…
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Pharmacology & Pharmacy is a peer reviewed international journal dedicated to the latest advancements in Pharmacology & Pharmacy. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to PP… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
Authors submit their manuscript, metadata, and declarations through the portal. There is no submission fee.
The editorial office screens the manuscript for scope, completeness, and formatting before assigning a handling editor.
At least two independent reviewers evaluate the manuscript under single-blind review. Where revisions are required, authors respond point by point.
On acceptance the article processing charge is invoiced and the CC BY 4.0 copyright handover is signed.
The article is copyedited, typeset, and given a DOI, then publishes open access with a permanent link.
Manuscripts must be original and not under consideration elsewhere. Submit in Microsoft Word or LaTeX with figures at 300 dpi minimum. Structure research articles as Abstract, Introduction, Methods, Results, Discussion, and References.
Use the journal's numbered (Vancouver) reference style. Cite sources consecutively in the order they appear, and ensure every reference is complete and retrievable.
Declare all funding sources, conflicts of interest, and ethical approvals (including informed consent and animal-care statements where applicable).